The long non-coding RNA ZFAS1 promotes colorectal cancer progression via miR200b/ZEB1 axis
Colorectal cancer (CRC) is a common tumor worldwide. CRC is influenced by several types of miRNAs and long non-coding RNAs. This study aims to evaluate the correlation of lncRNA ZFAS1/ miR200b/ ZEB1 protein with presence of CRC. Quantitative real-time polymerase chain reaction was used to measure se...
Gespeichert in:
| Veröffentlicht in: | Pathology, research and practice research and practice, 2023-07, Vol.247, p.154567-154567, Article 154567 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 154567 |
|---|---|
| container_issue | |
| container_start_page | 154567 |
| container_title | Pathology, research and practice |
| container_volume | 247 |
| creator | Salman, Islam T. Abulsoud, Ahmed I. Abo-Elmatty, Dina M. Fawzy, Amal Mesbah, Noha M. Saleh, Samy M. |
| description | Colorectal cancer (CRC) is a common tumor worldwide. CRC is influenced by several types of miRNAs and long non-coding RNAs. This study aims to evaluate the correlation of lncRNA ZFAS1/ miR200b/ ZEB1 protein with presence of CRC.
Quantitative real-time polymerase chain reaction was used to measure serum expression of lncRNA ZFAS1 and microRNA-200b in 60 CRC patients and 28 control subjects. ZEB1 protein in serum was measured by ELISA.
Lnc ZFAS1 and ZEB1 were up-regulated in CRC patients in compare to control subjects while miR-200b was down-regulated. There was a linear correlation between ZAFS1 expression and miR-200b and ZEB1 in CRC.
ZFAS1 is a key player of CRC progression and could be a potential therapeutic target by sponging miR-200b. In-addition the association between ZFAS1, miR-200b and ZEB1 highlights their potential value as a novel diagnostic biomarker in human CRC.
[Display omitted] |
| doi_str_mv | 10.1016/j.prp.2023.154567 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2820337824</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0344033823002674</els_id><sourcerecordid>2820337824</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-1503672866e13f2910fc2629265eb166fda932f2739636653e2bc7eb254470da3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EglL4ADbISzYp9jhxUrEqVXlIFUg8Nt1YjjMBV0kc7LaCv8dVgSWrGc3cezVzCDnjbMQZl5fLUe_7ETAQI56lmcz3yIBLXiRMCr5PBkykacKEKI7IcQhLxljOUn5IjkQOaQZSDsji5R1p47o32rkuMa6ysX16mNDFzeSZ09671q0wUOMa59GsdEON7gz67erNYwjWdXRjNW3tEzBWXi5m15zqTxtOyEGtm4CnP3VIXm9mL9O7ZP54ez-dzBMjMrFKeMaEzKGQErmoYcxZbUDCGGSGJZeyrvRYQA25GEshZSYQSpNjCVma5qzSYkgudrnxoo81hpVqbTDYNLpDtw4KCogM8gLSKOU7qfEuBI-16r1ttf9SnKktUrWMk15tkaod0ug5_4lfly1Wf45fhlFwtRNgfHJj0atgLEZGld0SU5Wz_8R_A9qGg6I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2820337824</pqid></control><display><type>article</type><title>The long non-coding RNA ZFAS1 promotes colorectal cancer progression via miR200b/ZEB1 axis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Salman, Islam T. ; Abulsoud, Ahmed I. ; Abo-Elmatty, Dina M. ; Fawzy, Amal ; Mesbah, Noha M. ; Saleh, Samy M.</creator><creatorcontrib>Salman, Islam T. ; Abulsoud, Ahmed I. ; Abo-Elmatty, Dina M. ; Fawzy, Amal ; Mesbah, Noha M. ; Saleh, Samy M.</creatorcontrib><description>Colorectal cancer (CRC) is a common tumor worldwide. CRC is influenced by several types of miRNAs and long non-coding RNAs. This study aims to evaluate the correlation of lncRNA ZFAS1/ miR200b/ ZEB1 protein with presence of CRC.
Quantitative real-time polymerase chain reaction was used to measure serum expression of lncRNA ZFAS1 and microRNA-200b in 60 CRC patients and 28 control subjects. ZEB1 protein in serum was measured by ELISA.
Lnc ZFAS1 and ZEB1 were up-regulated in CRC patients in compare to control subjects while miR-200b was down-regulated. There was a linear correlation between ZAFS1 expression and miR-200b and ZEB1 in CRC.
ZFAS1 is a key player of CRC progression and could be a potential therapeutic target by sponging miR-200b. In-addition the association between ZFAS1, miR-200b and ZEB1 highlights their potential value as a novel diagnostic biomarker in human CRC.
[Display omitted]</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/j.prp.2023.154567</identifier><identifier>PMID: 37245266</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Cell Line, Tumor ; Cell Proliferation - genetics ; Colorectal cancer ; Colorectal Neoplasms - pathology ; Gene Expression Regulation, Neoplastic - genetics ; Humans ; LncRNA ; MicroRNAs - genetics ; MicroRNAs - metabolism ; MiR200b ; Neoplasm Invasiveness - genetics ; Neoplastic Processes ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; ZEB1 ; ZFASI ; Zinc Finger E-box-Binding Homeobox 1 - genetics ; Zinc Finger E-box-Binding Homeobox 1 - metabolism</subject><ispartof>Pathology, research and practice, 2023-07, Vol.247, p.154567-154567, Article 154567</ispartof><rights>2023 Elsevier GmbH</rights><rights>Copyright © 2023 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-1503672866e13f2910fc2629265eb166fda932f2739636653e2bc7eb254470da3</citedby><cites>FETCH-LOGICAL-c353t-1503672866e13f2910fc2629265eb166fda932f2739636653e2bc7eb254470da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0344033823002674$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37245266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salman, Islam T.</creatorcontrib><creatorcontrib>Abulsoud, Ahmed I.</creatorcontrib><creatorcontrib>Abo-Elmatty, Dina M.</creatorcontrib><creatorcontrib>Fawzy, Amal</creatorcontrib><creatorcontrib>Mesbah, Noha M.</creatorcontrib><creatorcontrib>Saleh, Samy M.</creatorcontrib><title>The long non-coding RNA ZFAS1 promotes colorectal cancer progression via miR200b/ZEB1 axis</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>Colorectal cancer (CRC) is a common tumor worldwide. CRC is influenced by several types of miRNAs and long non-coding RNAs. This study aims to evaluate the correlation of lncRNA ZFAS1/ miR200b/ ZEB1 protein with presence of CRC.
Quantitative real-time polymerase chain reaction was used to measure serum expression of lncRNA ZFAS1 and microRNA-200b in 60 CRC patients and 28 control subjects. ZEB1 protein in serum was measured by ELISA.
Lnc ZFAS1 and ZEB1 were up-regulated in CRC patients in compare to control subjects while miR-200b was down-regulated. There was a linear correlation between ZAFS1 expression and miR-200b and ZEB1 in CRC.
ZFAS1 is a key player of CRC progression and could be a potential therapeutic target by sponging miR-200b. In-addition the association between ZFAS1, miR-200b and ZEB1 highlights their potential value as a novel diagnostic biomarker in human CRC.
[Display omitted]</description><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - genetics</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Humans</subject><subject>LncRNA</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>MiR200b</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Neoplastic Processes</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>ZEB1</subject><subject>ZFASI</subject><subject>Zinc Finger E-box-Binding Homeobox 1 - genetics</subject><subject>Zinc Finger E-box-Binding Homeobox 1 - metabolism</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EglL4ADbISzYp9jhxUrEqVXlIFUg8Nt1YjjMBV0kc7LaCv8dVgSWrGc3cezVzCDnjbMQZl5fLUe_7ETAQI56lmcz3yIBLXiRMCr5PBkykacKEKI7IcQhLxljOUn5IjkQOaQZSDsji5R1p47o32rkuMa6ysX16mNDFzeSZ09671q0wUOMa59GsdEON7gz67erNYwjWdXRjNW3tEzBWXi5m15zqTxtOyEGtm4CnP3VIXm9mL9O7ZP54ez-dzBMjMrFKeMaEzKGQErmoYcxZbUDCGGSGJZeyrvRYQA25GEshZSYQSpNjCVma5qzSYkgudrnxoo81hpVqbTDYNLpDtw4KCogM8gLSKOU7qfEuBI-16r1ttf9SnKktUrWMk15tkaod0ug5_4lfly1Wf45fhlFwtRNgfHJj0atgLEZGld0SU5Wz_8R_A9qGg6I</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Salman, Islam T.</creator><creator>Abulsoud, Ahmed I.</creator><creator>Abo-Elmatty, Dina M.</creator><creator>Fawzy, Amal</creator><creator>Mesbah, Noha M.</creator><creator>Saleh, Samy M.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202307</creationdate><title>The long non-coding RNA ZFAS1 promotes colorectal cancer progression via miR200b/ZEB1 axis</title><author>Salman, Islam T. ; Abulsoud, Ahmed I. ; Abo-Elmatty, Dina M. ; Fawzy, Amal ; Mesbah, Noha M. ; Saleh, Samy M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-1503672866e13f2910fc2629265eb166fda932f2739636653e2bc7eb254470da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - genetics</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Humans</topic><topic>LncRNA</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>MiR200b</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>Neoplastic Processes</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>ZEB1</topic><topic>ZFASI</topic><topic>Zinc Finger E-box-Binding Homeobox 1 - genetics</topic><topic>Zinc Finger E-box-Binding Homeobox 1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salman, Islam T.</creatorcontrib><creatorcontrib>Abulsoud, Ahmed I.</creatorcontrib><creatorcontrib>Abo-Elmatty, Dina M.</creatorcontrib><creatorcontrib>Fawzy, Amal</creatorcontrib><creatorcontrib>Mesbah, Noha M.</creatorcontrib><creatorcontrib>Saleh, Samy M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salman, Islam T.</au><au>Abulsoud, Ahmed I.</au><au>Abo-Elmatty, Dina M.</au><au>Fawzy, Amal</au><au>Mesbah, Noha M.</au><au>Saleh, Samy M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The long non-coding RNA ZFAS1 promotes colorectal cancer progression via miR200b/ZEB1 axis</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2023-07</date><risdate>2023</risdate><volume>247</volume><spage>154567</spage><epage>154567</epage><pages>154567-154567</pages><artnum>154567</artnum><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>Colorectal cancer (CRC) is a common tumor worldwide. CRC is influenced by several types of miRNAs and long non-coding RNAs. This study aims to evaluate the correlation of lncRNA ZFAS1/ miR200b/ ZEB1 protein with presence of CRC.
Quantitative real-time polymerase chain reaction was used to measure serum expression of lncRNA ZFAS1 and microRNA-200b in 60 CRC patients and 28 control subjects. ZEB1 protein in serum was measured by ELISA.
Lnc ZFAS1 and ZEB1 were up-regulated in CRC patients in compare to control subjects while miR-200b was down-regulated. There was a linear correlation between ZAFS1 expression and miR-200b and ZEB1 in CRC.
ZFAS1 is a key player of CRC progression and could be a potential therapeutic target by sponging miR-200b. In-addition the association between ZFAS1, miR-200b and ZEB1 highlights their potential value as a novel diagnostic biomarker in human CRC.
[Display omitted]</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>37245266</pmid><doi>10.1016/j.prp.2023.154567</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0344-0338 |
| ispartof | Pathology, research and practice, 2023-07, Vol.247, p.154567-154567, Article 154567 |
| issn | 0344-0338 1618-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2820337824 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Cell Line, Tumor Cell Proliferation - genetics Colorectal cancer Colorectal Neoplasms - pathology Gene Expression Regulation, Neoplastic - genetics Humans LncRNA MicroRNAs - genetics MicroRNAs - metabolism MiR200b Neoplasm Invasiveness - genetics Neoplastic Processes RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism ZEB1 ZFASI Zinc Finger E-box-Binding Homeobox 1 - genetics Zinc Finger E-box-Binding Homeobox 1 - metabolism |
| title | The long non-coding RNA ZFAS1 promotes colorectal cancer progression via miR200b/ZEB1 axis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T22%3A55%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20long%20non-coding%20RNA%20ZFAS1%20promotes%20colorectal%20cancer%20progression%20via%20miR200b/ZEB1%20axis&rft.jtitle=Pathology,%20research%20and%20practice&rft.au=Salman,%20Islam%20T.&rft.date=2023-07&rft.volume=247&rft.spage=154567&rft.epage=154567&rft.pages=154567-154567&rft.artnum=154567&rft.issn=0344-0338&rft.eissn=1618-0631&rft_id=info:doi/10.1016/j.prp.2023.154567&rft_dat=%3Cproquest_cross%3E2820337824%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2820337824&rft_id=info:pmid/37245266&rft_els_id=S0344033823002674&rfr_iscdi=true |