The regulatory role of PI3K in ageing-related diseases
Ageing is a physiological/pathological process accompanied by the progressive damage of cell function, triggering various ageing-related disorders. Phosphatidylinositol 3-kinase (PI3K), which serves as one of the central regulators of ageing, is closely associated with cellular characteristics or mo...
Gespeichert in:
| Veröffentlicht in: | Ageing research reviews 2023-07, Vol.88, p.101963-101963, Article 101963 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 101963 |
|---|---|
| container_issue | |
| container_start_page | 101963 |
| container_title | Ageing research reviews |
| container_volume | 88 |
| creator | Liu, Yanqing Liu, Qiong Zhang, Zhe Yang, Yaru Zhou, Yazhe Yan, Huanle Wang, Xin Li, Xiaoru Zhao, Jing Hu, Jingyan Yang, Shulin Tian, Yifan Yao, Yu Qiu, Zhenye Song, Yanbin Yang, Yang |
| description | Ageing is a physiological/pathological process accompanied by the progressive damage of cell function, triggering various ageing-related disorders. Phosphatidylinositol 3-kinase (PI3K), which serves as one of the central regulators of ageing, is closely associated with cellular characteristics or molecular features, such as genome instability, telomere erosion, epigenetic alterations, and mitochondrial dysfunction. In this review, the PI3K signalling pathway was firstly thoroughly explained. The link between ageing pathogenesis and the PI3K signalling pathway was then summarized. Finally, the key regulatory roles of PI3K in ageing-related illnesses were investigated and stressed. In summary, we revealed that drug development and clinical application targeting PI3K is one of the focal points for delaying ageing and treating ageing-related diseases in the future.
•Ageing is a complex process that copes with several cellular processes, including genomic instability, oxidative stress, etc.•PI3K has three subtypes and mediates multiple downstream molecules such as mTOR and FOXO.•PI3K is involved in ageing-related biological processes and plays a regulatory role in ageing-related diseases.•The study of PI3K subtypes is the key to developing the drugs that target PI3K to combat ageing-related diseases. |
| doi_str_mv | 10.1016/j.arr.2023.101963 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2820337168</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1568163723001228</els_id><sourcerecordid>2820337168</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-5a19b2b61dfb700e5dd910e61a19502e8c9eed4ade6ba3e3d0b0fe86536deaea3</originalsourceid><addsrcrecordid>eNp9kDtPwzAUhS0EoqXwA1iQR5YU27dxEjGhikdFJRjKbDn2TXGVJsVOkPrvcZXCyHRf5xzpfoRcczbljMu7zVR7PxVMwGEuJJyQMc8zkRRyVpzGPpV5wiVkI3IRwoZFTyHFORlBJmapBBgTufpE6nHd17pr_Z76tkbaVvR9Aa_UNVSv0TXrxGO8o6XWBdQBwyU5q3Qd8OpYJ-Tj6XE1f0mWb8-L-cMyMZBCl6SaF6UoJbdVmTGGqbUFZyh53KdMYG4KRDvTFmWpAcGyklWYyxSkRY0aJuR2yN359qvH0KmtCwbrWjfY9kGJXDCAjMs8SvkgNb4NwWOldt5ttd8rztQBl9qoiEsdcKkBV_TcHOP7cov2z_HLJwruBwHGJ78dehWMw8agdR5Np2zr_on_AafGef8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2820337168</pqid></control><display><type>article</type><title>The regulatory role of PI3K in ageing-related diseases</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Liu, Yanqing ; Liu, Qiong ; Zhang, Zhe ; Yang, Yaru ; Zhou, Yazhe ; Yan, Huanle ; Wang, Xin ; Li, Xiaoru ; Zhao, Jing ; Hu, Jingyan ; Yang, Shulin ; Tian, Yifan ; Yao, Yu ; Qiu, Zhenye ; Song, Yanbin ; Yang, Yang</creator><creatorcontrib>Liu, Yanqing ; Liu, Qiong ; Zhang, Zhe ; Yang, Yaru ; Zhou, Yazhe ; Yan, Huanle ; Wang, Xin ; Li, Xiaoru ; Zhao, Jing ; Hu, Jingyan ; Yang, Shulin ; Tian, Yifan ; Yao, Yu ; Qiu, Zhenye ; Song, Yanbin ; Yang, Yang</creatorcontrib><description>Ageing is a physiological/pathological process accompanied by the progressive damage of cell function, triggering various ageing-related disorders. Phosphatidylinositol 3-kinase (PI3K), which serves as one of the central regulators of ageing, is closely associated with cellular characteristics or molecular features, such as genome instability, telomere erosion, epigenetic alterations, and mitochondrial dysfunction. In this review, the PI3K signalling pathway was firstly thoroughly explained. The link between ageing pathogenesis and the PI3K signalling pathway was then summarized. Finally, the key regulatory roles of PI3K in ageing-related illnesses were investigated and stressed. In summary, we revealed that drug development and clinical application targeting PI3K is one of the focal points for delaying ageing and treating ageing-related diseases in the future.
•Ageing is a complex process that copes with several cellular processes, including genomic instability, oxidative stress, etc.•PI3K has three subtypes and mediates multiple downstream molecules such as mTOR and FOXO.•PI3K is involved in ageing-related biological processes and plays a regulatory role in ageing-related diseases.•The study of PI3K subtypes is the key to developing the drugs that target PI3K to combat ageing-related diseases.</description><identifier>ISSN: 1568-1637</identifier><identifier>EISSN: 1872-9649</identifier><identifier>DOI: 10.1016/j.arr.2023.101963</identifier><identifier>PMID: 37245633</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Ageing-related diseases ; Aging - pathology ; Aging - physiology ; Animals ; Heart Diseases - metabolism ; Heart Diseases - pathology ; Humans ; Metabolic Diseases - metabolism ; Metabolic Diseases - pathology ; Neoplasms - metabolism ; Neoplasms - pathology ; Neurodegenerative Diseases - metabolism ; Neurodegenerative Diseases - pathology ; Older people ; Phosphatidylinositol 3-Kinase - metabolism ; PI3K ; Signal Transduction</subject><ispartof>Ageing research reviews, 2023-07, Vol.88, p.101963-101963, Article 101963</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-5a19b2b61dfb700e5dd910e61a19502e8c9eed4ade6ba3e3d0b0fe86536deaea3</citedby><cites>FETCH-LOGICAL-c353t-5a19b2b61dfb700e5dd910e61a19502e8c9eed4ade6ba3e3d0b0fe86536deaea3</cites><orcidid>0000-0002-1163-2359</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1568163723001228$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37245633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yanqing</creatorcontrib><creatorcontrib>Liu, Qiong</creatorcontrib><creatorcontrib>Zhang, Zhe</creatorcontrib><creatorcontrib>Yang, Yaru</creatorcontrib><creatorcontrib>Zhou, Yazhe</creatorcontrib><creatorcontrib>Yan, Huanle</creatorcontrib><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Li, Xiaoru</creatorcontrib><creatorcontrib>Zhao, Jing</creatorcontrib><creatorcontrib>Hu, Jingyan</creatorcontrib><creatorcontrib>Yang, Shulin</creatorcontrib><creatorcontrib>Tian, Yifan</creatorcontrib><creatorcontrib>Yao, Yu</creatorcontrib><creatorcontrib>Qiu, Zhenye</creatorcontrib><creatorcontrib>Song, Yanbin</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><title>The regulatory role of PI3K in ageing-related diseases</title><title>Ageing research reviews</title><addtitle>Ageing Res Rev</addtitle><description>Ageing is a physiological/pathological process accompanied by the progressive damage of cell function, triggering various ageing-related disorders. Phosphatidylinositol 3-kinase (PI3K), which serves as one of the central regulators of ageing, is closely associated with cellular characteristics or molecular features, such as genome instability, telomere erosion, epigenetic alterations, and mitochondrial dysfunction. In this review, the PI3K signalling pathway was firstly thoroughly explained. The link between ageing pathogenesis and the PI3K signalling pathway was then summarized. Finally, the key regulatory roles of PI3K in ageing-related illnesses were investigated and stressed. In summary, we revealed that drug development and clinical application targeting PI3K is one of the focal points for delaying ageing and treating ageing-related diseases in the future.
•Ageing is a complex process that copes with several cellular processes, including genomic instability, oxidative stress, etc.•PI3K has three subtypes and mediates multiple downstream molecules such as mTOR and FOXO.•PI3K is involved in ageing-related biological processes and plays a regulatory role in ageing-related diseases.•The study of PI3K subtypes is the key to developing the drugs that target PI3K to combat ageing-related diseases.</description><subject>Ageing-related diseases</subject><subject>Aging - pathology</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Heart Diseases - metabolism</subject><subject>Heart Diseases - pathology</subject><subject>Humans</subject><subject>Metabolic Diseases - metabolism</subject><subject>Metabolic Diseases - pathology</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neurodegenerative Diseases - metabolism</subject><subject>Neurodegenerative Diseases - pathology</subject><subject>Older people</subject><subject>Phosphatidylinositol 3-Kinase - metabolism</subject><subject>PI3K</subject><subject>Signal Transduction</subject><issn>1568-1637</issn><issn>1872-9649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS0EoqXwA1iQR5YU27dxEjGhikdFJRjKbDn2TXGVJsVOkPrvcZXCyHRf5xzpfoRcczbljMu7zVR7PxVMwGEuJJyQMc8zkRRyVpzGPpV5wiVkI3IRwoZFTyHFORlBJmapBBgTufpE6nHd17pr_Z76tkbaVvR9Aa_UNVSv0TXrxGO8o6XWBdQBwyU5q3Qd8OpYJ-Tj6XE1f0mWb8-L-cMyMZBCl6SaF6UoJbdVmTGGqbUFZyh53KdMYG4KRDvTFmWpAcGyklWYyxSkRY0aJuR2yN359qvH0KmtCwbrWjfY9kGJXDCAjMs8SvkgNb4NwWOldt5ttd8rztQBl9qoiEsdcKkBV_TcHOP7cov2z_HLJwruBwHGJ78dehWMw8agdR5Np2zr_on_AafGef8</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Liu, Yanqing</creator><creator>Liu, Qiong</creator><creator>Zhang, Zhe</creator><creator>Yang, Yaru</creator><creator>Zhou, Yazhe</creator><creator>Yan, Huanle</creator><creator>Wang, Xin</creator><creator>Li, Xiaoru</creator><creator>Zhao, Jing</creator><creator>Hu, Jingyan</creator><creator>Yang, Shulin</creator><creator>Tian, Yifan</creator><creator>Yao, Yu</creator><creator>Qiu, Zhenye</creator><creator>Song, Yanbin</creator><creator>Yang, Yang</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1163-2359</orcidid></search><sort><creationdate>202307</creationdate><title>The regulatory role of PI3K in ageing-related diseases</title><author>Liu, Yanqing ; Liu, Qiong ; Zhang, Zhe ; Yang, Yaru ; Zhou, Yazhe ; Yan, Huanle ; Wang, Xin ; Li, Xiaoru ; Zhao, Jing ; Hu, Jingyan ; Yang, Shulin ; Tian, Yifan ; Yao, Yu ; Qiu, Zhenye ; Song, Yanbin ; Yang, Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-5a19b2b61dfb700e5dd910e61a19502e8c9eed4ade6ba3e3d0b0fe86536deaea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Ageing-related diseases</topic><topic>Aging - pathology</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Heart Diseases - metabolism</topic><topic>Heart Diseases - pathology</topic><topic>Humans</topic><topic>Metabolic Diseases - metabolism</topic><topic>Metabolic Diseases - pathology</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neurodegenerative Diseases - metabolism</topic><topic>Neurodegenerative Diseases - pathology</topic><topic>Older people</topic><topic>Phosphatidylinositol 3-Kinase - metabolism</topic><topic>PI3K</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yanqing</creatorcontrib><creatorcontrib>Liu, Qiong</creatorcontrib><creatorcontrib>Zhang, Zhe</creatorcontrib><creatorcontrib>Yang, Yaru</creatorcontrib><creatorcontrib>Zhou, Yazhe</creatorcontrib><creatorcontrib>Yan, Huanle</creatorcontrib><creatorcontrib>Wang, Xin</creatorcontrib><creatorcontrib>Li, Xiaoru</creatorcontrib><creatorcontrib>Zhao, Jing</creatorcontrib><creatorcontrib>Hu, Jingyan</creatorcontrib><creatorcontrib>Yang, Shulin</creatorcontrib><creatorcontrib>Tian, Yifan</creatorcontrib><creatorcontrib>Yao, Yu</creatorcontrib><creatorcontrib>Qiu, Zhenye</creatorcontrib><creatorcontrib>Song, Yanbin</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ageing research reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yanqing</au><au>Liu, Qiong</au><au>Zhang, Zhe</au><au>Yang, Yaru</au><au>Zhou, Yazhe</au><au>Yan, Huanle</au><au>Wang, Xin</au><au>Li, Xiaoru</au><au>Zhao, Jing</au><au>Hu, Jingyan</au><au>Yang, Shulin</au><au>Tian, Yifan</au><au>Yao, Yu</au><au>Qiu, Zhenye</au><au>Song, Yanbin</au><au>Yang, Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The regulatory role of PI3K in ageing-related diseases</atitle><jtitle>Ageing research reviews</jtitle><addtitle>Ageing Res Rev</addtitle><date>2023-07</date><risdate>2023</risdate><volume>88</volume><spage>101963</spage><epage>101963</epage><pages>101963-101963</pages><artnum>101963</artnum><issn>1568-1637</issn><eissn>1872-9649</eissn><abstract>Ageing is a physiological/pathological process accompanied by the progressive damage of cell function, triggering various ageing-related disorders. Phosphatidylinositol 3-kinase (PI3K), which serves as one of the central regulators of ageing, is closely associated with cellular characteristics or molecular features, such as genome instability, telomere erosion, epigenetic alterations, and mitochondrial dysfunction. In this review, the PI3K signalling pathway was firstly thoroughly explained. The link between ageing pathogenesis and the PI3K signalling pathway was then summarized. Finally, the key regulatory roles of PI3K in ageing-related illnesses were investigated and stressed. In summary, we revealed that drug development and clinical application targeting PI3K is one of the focal points for delaying ageing and treating ageing-related diseases in the future.
•Ageing is a complex process that copes with several cellular processes, including genomic instability, oxidative stress, etc.•PI3K has three subtypes and mediates multiple downstream molecules such as mTOR and FOXO.•PI3K is involved in ageing-related biological processes and plays a regulatory role in ageing-related diseases.•The study of PI3K subtypes is the key to developing the drugs that target PI3K to combat ageing-related diseases.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>37245633</pmid><doi>10.1016/j.arr.2023.101963</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1163-2359</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1568-1637 |
| ispartof | Ageing research reviews, 2023-07, Vol.88, p.101963-101963, Article 101963 |
| issn | 1568-1637 1872-9649 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2820337168 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Ageing-related diseases Aging - pathology Aging - physiology Animals Heart Diseases - metabolism Heart Diseases - pathology Humans Metabolic Diseases - metabolism Metabolic Diseases - pathology Neoplasms - metabolism Neoplasms - pathology Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Older people Phosphatidylinositol 3-Kinase - metabolism PI3K Signal Transduction |
| title | The regulatory role of PI3K in ageing-related diseases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T05%3A32%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20regulatory%20role%20of%20PI3K%20in%20ageing-related%20diseases&rft.jtitle=Ageing%20research%20reviews&rft.au=Liu,%20Yanqing&rft.date=2023-07&rft.volume=88&rft.spage=101963&rft.epage=101963&rft.pages=101963-101963&rft.artnum=101963&rft.issn=1568-1637&rft.eissn=1872-9649&rft_id=info:doi/10.1016/j.arr.2023.101963&rft_dat=%3Cproquest_cross%3E2820337168%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2820337168&rft_id=info:pmid/37245633&rft_els_id=S1568163723001228&rfr_iscdi=true |