Mutation spectrum of FLT3 and significance of non‐canonical FLT3 mutations in haematological malignancy

Summary Fms‐like tyrosine kinase 3 (FLT3) is frequently mutated in haematological malignancies. Although canonical FLT3 mutations including internal tandem duplications (ITDs) and tyrosine kinase domains (TKDs) have been extensively studied, little is known about the clinical significance of non‐can...

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Veröffentlicht in:	British journal of haematology 2023-08, Vol.202 (3), p.539-549
Hauptverfasser:	Ge, Shuai‐Shuai, Qiu, Qiao‐Cheng, Dai, Hai‐Ping, Shen, Xiang‐Dong, Wu, Tian‐Mei, Du, Jia‐Hui, Wan, Chao‐Ling, Shen, Hong‐Jie, Wu, De‐Pei, Xue, Sheng‐Li, Liu, Song‐Bai
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Acute myeloid leukemia Deletion mutant FLT3 FLT3 inhibitor fms-Like Tyrosine Kinase 3 - genetics Frameshift mutation Gene deletion haematological malignancy Hematologic Neoplasms Hematology Humans kinase activity Kinases Leukemia Leukemia, Myeloid, Acute - genetics Malignancy Mutants Mutation mutation spectrum Myelodysplastic syndrome Phosphorylation Point Mutation Protein structure Protein-tyrosine kinase
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