Divergent Synthesis of 1,1-Carbonyl Amino Alkyl Borons from Indoles

α-Boryl carbonyl species and α-boryl amino compounds are valuable and important frameworks in organic synthesis. However, the strategies that could merge the two scaffolds into one compound, named 1,1-carbonyl amino alkyl boron, are elusive and underdeveloped. Herein, we present an efficient method...

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Veröffentlicht in:	Organic letters 2023-06, Vol.25 (22), p.4038-4043
Hauptverfasser:	Hou, Mengyuan, Wang, Yahao, Li, Puhui, Ma, Xingxing, Zhang, Guan, Song, Qiuling
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creator	Hou, Mengyuan Wang, Yahao Li, Puhui Ma, Xingxing Zhang, Guan Song, Qiuling
description	α-Boryl carbonyl species and α-boryl amino compounds are valuable and important frameworks in organic synthesis. However, the strategies that could merge the two scaffolds into one compound, named 1,1-carbonyl amino alkyl boron, are elusive and underdeveloped. Herein, we present an efficient method that could address this gap and produce 1,1-carbonyl amino alkyl borons from readily accessible indoles via oxidation by m-CPBA or oxone. This reaction features operational simplicity, divergent synthesis, broad substrate scope, and valuable products.
doi_str_mv	10.1021/acs.orglett.3c01190
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title	Divergent Synthesis of 1,1-Carbonyl Amino Alkyl Borons from Indoles
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