Coronary microcirculation and left ventricular diastolic function but not myocardial deformation indices are impaired early in patients with chronic kidney disease

Aim To investigate abnormalities in myocardial strain and classic echocardiographic indices and coronary flow reserve (CFR), in younger versus older CKD patients. Methods Sixty consecutive CKD patients (

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Veröffentlicht in:Echocardiography (Mount Kisco, N.Y.) N.Y.), 2023-07, Vol.40 (7), p.600-607
Hauptverfasser: Lakkas, Lampros, Naka, Katerina K., Bechlioulis, Aris, Duni, Anila, Moustakli, Maria, Balafa, Olga, Theodorou, Ioanna, Katsouras, Christos S., Dounousi, Evangelia, Michalis, Lampros K.
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container_issue 7
container_start_page 600
container_title Echocardiography (Mount Kisco, N.Y.)
container_volume 40
creator Lakkas, Lampros
Naka, Katerina K.
Bechlioulis, Aris
Duni, Anila
Moustakli, Maria
Balafa, Olga
Theodorou, Ioanna
Katsouras, Christos S.
Dounousi, Evangelia
Michalis, Lampros K.
description Aim To investigate abnormalities in myocardial strain and classic echocardiographic indices and coronary flow reserve (CFR), in younger versus older CKD patients. Methods Sixty consecutive CKD patients (
doi_str_mv 10.1111/echo.15598
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Methods Sixty consecutive CKD patients (&lt;60 years old n = 30, ≥60 years old n = 30) and 30 healthy controls (age‐ and gender‐matched with younger CKD patients) were recruited. An echocardiographic assessment including myocardial strain indices (i.e. global longitudinal strain ‐GLS ‐, TWIST, UNTWIST rate) was performed at baseline and following dipyridamole administration in all participants. Results Younger CKD patients had higher E/e', left ventricular mass index and relative wall thickness and lower E' (p &lt; .005 for all) compared to healthy controls. Older CKD patients had lower E/A and E' (p &lt; .05 for both) compared to younger CKD patients; these differences did not remain significant after adjustment for age. CFR was higher in healthy controls compared to younger and older CKD patients (p &lt; .05 for both) without a significant difference between CKD groups. There were no significant differences in GLS, TWIST or UNTWIST values among the three groups of patients. Dipyridamole‐induced changes did not differ significantly among the three groups. Conclusions Compared to healthy controls, impaired coronary microcirculation and left ventricular diastolic function, but not myocardial strain abnormalities, are found in young CKD patients and deteriorate with aging.</description><identifier>ISSN: 0742-2822</identifier><identifier>EISSN: 1540-8175</identifier><identifier>DOI: 10.1111/echo.15598</identifier><identifier>PMID: 37229577</identifier><language>eng</language><publisher>United States</publisher><subject>chronic kidney disease ; coronary flow reserve ; diastolic function ; dipyridamole ; myocardial strain</subject><ispartof>Echocardiography (Mount Kisco, N.Y.), 2023-07, Vol.40 (7), p.600-607</ispartof><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3658-7a95f49402fb80a34c67bbfb4dc63ddf66c81d686f3efae971c08a57c42f57823</citedby><cites>FETCH-LOGICAL-c3658-7a95f49402fb80a34c67bbfb4dc63ddf66c81d686f3efae971c08a57c42f57823</cites><orcidid>0000-0003-1721-2539</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fecho.15598$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fecho.15598$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37229577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lakkas, Lampros</creatorcontrib><creatorcontrib>Naka, Katerina K.</creatorcontrib><creatorcontrib>Bechlioulis, Aris</creatorcontrib><creatorcontrib>Duni, Anila</creatorcontrib><creatorcontrib>Moustakli, Maria</creatorcontrib><creatorcontrib>Balafa, Olga</creatorcontrib><creatorcontrib>Theodorou, Ioanna</creatorcontrib><creatorcontrib>Katsouras, Christos S.</creatorcontrib><creatorcontrib>Dounousi, Evangelia</creatorcontrib><creatorcontrib>Michalis, Lampros K.</creatorcontrib><title>Coronary microcirculation and left ventricular diastolic function but not myocardial deformation indices are impaired early in patients with chronic kidney disease</title><title>Echocardiography (Mount Kisco, N.Y.)</title><addtitle>Echocardiography</addtitle><description>Aim To investigate abnormalities in myocardial strain and classic echocardiographic indices and coronary flow reserve (CFR), in younger versus older CKD patients. Methods Sixty consecutive CKD patients (&lt;60 years old n = 30, ≥60 years old n = 30) and 30 healthy controls (age‐ and gender‐matched with younger CKD patients) were recruited. An echocardiographic assessment including myocardial strain indices (i.e. global longitudinal strain ‐GLS ‐, TWIST, UNTWIST rate) was performed at baseline and following dipyridamole administration in all participants. Results Younger CKD patients had higher E/e', left ventricular mass index and relative wall thickness and lower E' (p &lt; .005 for all) compared to healthy controls. Older CKD patients had lower E/A and E' (p &lt; .05 for both) compared to younger CKD patients; these differences did not remain significant after adjustment for age. CFR was higher in healthy controls compared to younger and older CKD patients (p &lt; .05 for both) without a significant difference between CKD groups. There were no significant differences in GLS, TWIST or UNTWIST values among the three groups of patients. Dipyridamole‐induced changes did not differ significantly among the three groups. Conclusions Compared to healthy controls, impaired coronary microcirculation and left ventricular diastolic function, but not myocardial strain abnormalities, are found in young CKD patients and deteriorate with aging.</description><subject>chronic kidney disease</subject><subject>coronary flow reserve</subject><subject>diastolic function</subject><subject>dipyridamole</subject><subject>myocardial strain</subject><issn>0742-2822</issn><issn>1540-8175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kcFuFSEUhomxsdfqxgcwLE2TqcDAwCzNTWtNmnSj6wkDh1yUgSvM2Mzz9EXL7VSXsjkJfPkO-X-EPlByRev5DOaQrqgQvXqFdlRw0igqxWu0I5KzhinGztHbUn4SQiSl_A06byVjvZByhx73Kaeo84onb3IyPpsl6NmniHW0OICb8R-Ic_an-4yt12VOwRvslmieuXGZcUwzntZkdK5AwBZcytOm8dF6AwXrDNhPR-0zWAw6h7U-4WOFqr7gBz8fsDnUz1T3L28jrHVZAV3gHTpzOhR4_zIv0I-b6-_72-bu_uu3_Ze7xrSdUI3UvXC854S5URHdctPJcXQjt6ZrrXVdZxS1nepcC05DL6khSgtpOHNCKtZeoE-b95jT7wXKPEy-GAhBR0hLGWqShLSUSV7Ryw2tmZWSwQ3H7Kca40DJcCplOJUyPJdS4Y8v3mWcwP5D_7ZQAboBDz7A-h_VcL2_vd-kTwN6nIM</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Lakkas, Lampros</creator><creator>Naka, Katerina K.</creator><creator>Bechlioulis, Aris</creator><creator>Duni, Anila</creator><creator>Moustakli, Maria</creator><creator>Balafa, Olga</creator><creator>Theodorou, Ioanna</creator><creator>Katsouras, Christos S.</creator><creator>Dounousi, Evangelia</creator><creator>Michalis, Lampros K.</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1721-2539</orcidid></search><sort><creationdate>202307</creationdate><title>Coronary microcirculation and left ventricular diastolic function but not myocardial deformation indices are impaired early in patients with chronic kidney disease</title><author>Lakkas, Lampros ; Naka, Katerina K. ; Bechlioulis, Aris ; Duni, Anila ; Moustakli, Maria ; Balafa, Olga ; Theodorou, Ioanna ; Katsouras, Christos S. ; Dounousi, Evangelia ; Michalis, Lampros K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3658-7a95f49402fb80a34c67bbfb4dc63ddf66c81d686f3efae971c08a57c42f57823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>chronic kidney disease</topic><topic>coronary flow reserve</topic><topic>diastolic function</topic><topic>dipyridamole</topic><topic>myocardial strain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lakkas, Lampros</creatorcontrib><creatorcontrib>Naka, Katerina K.</creatorcontrib><creatorcontrib>Bechlioulis, Aris</creatorcontrib><creatorcontrib>Duni, Anila</creatorcontrib><creatorcontrib>Moustakli, Maria</creatorcontrib><creatorcontrib>Balafa, Olga</creatorcontrib><creatorcontrib>Theodorou, Ioanna</creatorcontrib><creatorcontrib>Katsouras, Christos S.</creatorcontrib><creatorcontrib>Dounousi, Evangelia</creatorcontrib><creatorcontrib>Michalis, Lampros K.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Echocardiography (Mount Kisco, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lakkas, Lampros</au><au>Naka, Katerina K.</au><au>Bechlioulis, Aris</au><au>Duni, Anila</au><au>Moustakli, Maria</au><au>Balafa, Olga</au><au>Theodorou, Ioanna</au><au>Katsouras, Christos S.</au><au>Dounousi, Evangelia</au><au>Michalis, Lampros K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary microcirculation and left ventricular diastolic function but not myocardial deformation indices are impaired early in patients with chronic kidney disease</atitle><jtitle>Echocardiography (Mount Kisco, N.Y.)</jtitle><addtitle>Echocardiography</addtitle><date>2023-07</date><risdate>2023</risdate><volume>40</volume><issue>7</issue><spage>600</spage><epage>607</epage><pages>600-607</pages><issn>0742-2822</issn><eissn>1540-8175</eissn><abstract>Aim To investigate abnormalities in myocardial strain and classic echocardiographic indices and coronary flow reserve (CFR), in younger versus older CKD patients. Methods Sixty consecutive CKD patients (&lt;60 years old n = 30, ≥60 years old n = 30) and 30 healthy controls (age‐ and gender‐matched with younger CKD patients) were recruited. An echocardiographic assessment including myocardial strain indices (i.e. global longitudinal strain ‐GLS ‐, TWIST, UNTWIST rate) was performed at baseline and following dipyridamole administration in all participants. Results Younger CKD patients had higher E/e', left ventricular mass index and relative wall thickness and lower E' (p &lt; .005 for all) compared to healthy controls. Older CKD patients had lower E/A and E' (p &lt; .05 for both) compared to younger CKD patients; these differences did not remain significant after adjustment for age. CFR was higher in healthy controls compared to younger and older CKD patients (p &lt; .05 for both) without a significant difference between CKD groups. There were no significant differences in GLS, TWIST or UNTWIST values among the three groups of patients. Dipyridamole‐induced changes did not differ significantly among the three groups. Conclusions Compared to healthy controls, impaired coronary microcirculation and left ventricular diastolic function, but not myocardial strain abnormalities, are found in young CKD patients and deteriorate with aging.</abstract><cop>United States</cop><pmid>37229577</pmid><doi>10.1111/echo.15598</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1721-2539</orcidid><oa>free_for_read</oa></addata></record>
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subjects chronic kidney disease
coronary flow reserve
diastolic function
dipyridamole
myocardial strain
title Coronary microcirculation and left ventricular diastolic function but not myocardial deformation indices are impaired early in patients with chronic kidney disease
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