CgWnt-1 regulates haemocyte proliferation during immune response of oyster Crassostrea gigas

Recent findings regarding the immunomodulatory role of Wnt signaling suggest that it is significant in regulating the differentiation and proliferation of immune cells. In the present study, a Wnt-1 homolog (designated as CgWnt-1) with a conserved WNT1 domain was identified from oyster Crassostrea g...

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Veröffentlicht in:	Developmental and comparative immunology 2023-09, Vol.146, p.104744-104744, Article 104744
Hauptverfasser:	Wu, Shasha, Wang, Weilin, Li, Qing, Li, Jialuo, Dong, Miren, Zhou, Xiaoxu, Wang, Lingling, Song, Linsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Crassostrea - genetics Crassostrea gigas Haemocytes proliferation Hemocytes Immunity, Innate - genetics Phagocytosis Recombinant Proteins - metabolism RNA, Messenger - genetics Wnt signal pathway Wnt-1
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Zusammenfassung:	Recent findings regarding the immunomodulatory role of Wnt signaling suggest that it is significant in regulating the differentiation and proliferation of immune cells. In the present study, a Wnt-1 homolog (designated as CgWnt-1) with a conserved WNT1 domain was identified from oyster Crassostrea gigas. The transcripts of CgWnt-1 were barely expressed in egg to gastrula stage during early embryogenesis, and up-regulated significantly in the trochophore to juvenile stage. The mRNA transcripts of CgWnt-1 were detected in different tissues of adult oyster, with an extremely high expression level in the mantle, which was 77.38-fold (p
ISSN:	0145-305X 1879-0089
DOI:	10.1016/j.dci.2023.104744