Synthesis, modeling, and biological evaluation of anti-tubulin indole-substituted furanones

[Display omitted] Due to the central role of tubulin in various cellular functions, it is a validated target for anti-cancer therapeutics. However, many of the current tubulin inhibitors are derived from complex natural products and suffer from multidrug resistance, low solubility, toxicity issues,...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2023-06, Vol.90, p.129347-129347, Article 129347
Hauptverfasser:	Hurysz, Brianna, Evans, Blake A., Laryea, Reuben N., Boyer, Brooke E., Coburn, Taylor E., Dexter, Molly S., Edwards, Marissa A., Faulkner, Grace V., Huss, Rebecca L., Lafferty, Megan M., Manning, Maegan, McNulty, Matthew, Melvin, Sophia J., Mitrow, Christina M., Patel, Roslyn R., Pierce, Kelsey, Russo, Jack, Seminer, Allie M., Sockett, Kaitlynn A., Webster, Nathan R., Cole, Kathryn E., Mowery, Patricia, Pelkey, Erin T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antiproliferative Antitubulin Binding Sites Cell Line, Tumor Cell Proliferation Colchicine - chemistry Drug Screening Assays, Antitumor Heterocyclic Indole Indoles - chemistry Molecular Docking Simulation Structure-Activity Relationship Tubulin - metabolism Tubulin Modulators - chemistry
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