Salvia officinalis L. Methanolic Extract Reduces Lead and Nicotine‐Induced Sperm Quality Degeneration in Male Rats
Most heavy metals and industrial chemicals such as nicotine and lead cause harm to the reproduction process through a decrease in sperm motility, fertilization process, and sperm binding to the oocyte. Salvia officinalis L. (sage) has been reported to enhance serum testosterone levels and other cert...
Gespeichert in:
| Veröffentlicht in: | Chemistry & biodiversity 2023-07, Vol.20 (7), p.e202300115-n/a |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 7 |
| container_start_page | e202300115 |
| container_title | Chemistry & biodiversity |
| container_volume | 20 |
| creator | Ammar Aldaddou, Wael Aljohani, Abdullah S. M. Adewale Ahmed, Idris Al‐Wabel, Naser A. El‐Ashmawy, Ibrahim M. |
| description | Most heavy metals and industrial chemicals such as nicotine and lead cause harm to the reproduction process through a decrease in sperm motility, fertilization process, and sperm binding to the oocyte. Salvia officinalis L. (sage) has been reported to enhance serum testosterone levels and other certain biochemical enzymes. Thus, the current study is aimed at evaluating the potential health benefits of S. officinalis L. methanol extract on lead and nicotine hydrogen tartrate‐induced sperm quality degeneration in male rats and also identifying some of the non‐polar volatile bioactive compounds that might be attributed to the bioactivity of S. officinalis extract using gas chromatography‐mass spectrometry (GC/MS). In the study, fifty‐four mature male albino rats of about 220–250 g [were divided randomly and equally into 9 groups (n=6)]. Sperm quality degeneration was induced through the oral administration of 1.5 g/L of lead acetate in drinking water or peritoneal injection of 0.50 mg/kg (animal weight) nicotine hydrogen tartrate for sixty days. Two doses (200 & 400 mg/kg b.w.) of S. officinalis L. were used. The rats were anesthetized after the experimental period and then sacrificed. Blood samples were collected while the epididymis, testicle, and accessory sex organs (prostates and seminal vesical) were taken for histopathological studies. Twelve major compounds were identified through the GC/MS analysis of S. officinalis L. methanol extract. Lead and nicotine toxicity had a great effect on the rats’ sperm quality causing a significant (p |
| doi_str_mv | 10.1002/cbdv.202300115 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2820026691</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2820026691</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3285-cf8458378b1db839cd6fbfeebab8e4b04ee943dd151f96a63d163db2bcf98cdc3</originalsourceid><addsrcrecordid>eNqFkU1PGzEQhi1ERYBy7bGyxKWXpP7YbLzHNlBACqAmwHXljzEYbbyp7aXkxk_gN_aX1FFCKvXCwRpr5pnnMC9CnygZUELYV63M04ARxgmhdLiD9mlJWZ8KQXa3_xHroYMYHzOf-2IP9fiI8bIi1T5KM9k8OYlba512XjYu4skAX0J6kL5tnManzylInfAUTKchT0EaLL3BV063yXn48_J64Vczg2cLCHP8s8uatMQncA8egkyu9dh5fCkbwFOZ4kf0wcomwtGmHqLbH6c34_P-5PrsYvxt0teciWFfW1EMBR8JRY0SvNKmtMoCKKkEFIoUAFXBjaFDaqtSltzQ_BRT2lZCG80P0Ze1dxHaXx3EVM9d1NA00kPbxZoJlm9SlhXN6PF_6GPbhXyPFVUQWhSs5JkarCkd2hgD2HoR3FyGZU1JvcqjXuVRb_PIC5832k7NwWzxtwAyUK2B366B5Tu6evz95O6f_C_qXZi0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2840144263</pqid></control><display><type>article</type><title>Salvia officinalis L. Methanolic Extract Reduces Lead and Nicotine‐Induced Sperm Quality Degeneration in Male Rats</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Ammar Aldaddou, Wael ; Aljohani, Abdullah S. M. ; Adewale Ahmed, Idris ; Al‐Wabel, Naser A. ; El‐Ashmawy, Ibrahim M.</creator><creatorcontrib>Ammar Aldaddou, Wael ; Aljohani, Abdullah S. M. ; Adewale Ahmed, Idris ; Al‐Wabel, Naser A. ; El‐Ashmawy, Ibrahim M.</creatorcontrib><description>Most heavy metals and industrial chemicals such as nicotine and lead cause harm to the reproduction process through a decrease in sperm motility, fertilization process, and sperm binding to the oocyte. Salvia officinalis L. (sage) has been reported to enhance serum testosterone levels and other certain biochemical enzymes. Thus, the current study is aimed at evaluating the potential health benefits of S. officinalis L. methanol extract on lead and nicotine hydrogen tartrate‐induced sperm quality degeneration in male rats and also identifying some of the non‐polar volatile bioactive compounds that might be attributed to the bioactivity of S. officinalis extract using gas chromatography‐mass spectrometry (GC/MS). In the study, fifty‐four mature male albino rats of about 220–250 g [were divided randomly and equally into 9 groups (n=6)]. Sperm quality degeneration was induced through the oral administration of 1.5 g/L of lead acetate in drinking water or peritoneal injection of 0.50 mg/kg (animal weight) nicotine hydrogen tartrate for sixty days. Two doses (200 & 400 mg/kg b.w.) of S. officinalis L. were used. The rats were anesthetized after the experimental period and then sacrificed. Blood samples were collected while the epididymis, testicle, and accessory sex organs (prostates and seminal vesical) were taken for histopathological studies. Twelve major compounds were identified through the GC/MS analysis of S. officinalis L. methanol extract. Lead and nicotine toxicity had a great effect on the rats’ sperm quality causing a significant (p<0.05) decrease in the quantity of sperm and sperm motility as well as an upsurge in the abnormalities of the sperm and a reduction in the length & diameter of seminiferous tubules and size & weight of sexual organs (accessory sex glands, epididymis, and testis). The administration of S. officinalis L. methanol extract, however, had a positive impact on the sexual organ weights, semen quality & quantity, and rats’ fertility, thus, ameliorating the adversative effects of both lead and nicotine. Further evaluation and isolation of the bioactive components are recommended as potential drug leads.</description><identifier>ISSN: 1612-1872</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.202300115</identifier><identifier>PMID: 37236909</identifier><language>eng</language><publisher>Switzerland: Wiley Subscription Services, Inc</publisher><subject>Abnormalities ; Animals ; Bioactive compounds ; Biocompatibility ; Biological activity ; Degeneration ; Drinking water ; Epididymis ; Fertility ; Fertilization ; Gametocytes ; Gas chromatography ; Heavy metals ; Hydrogen ; lead ; Lead acetates ; Male ; Males ; Mass spectrometry ; Mass spectroscopy ; Methanol ; Motility ; Nicotine ; Nicotine - pharmacology ; Oral administration ; Organs ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar ; Salvia officinalis ; Seeds ; Semen ; Semen Analysis ; Sex ; Sex glands ; Sperm ; Sperm Count - methods ; Sperm Motility ; sperm quality ; Spermatozoa ; Tartrates - pharmacology ; Testosterone ; Toxicity ; Tubules</subject><ispartof>Chemistry & biodiversity, 2023-07, Vol.20 (7), p.e202300115-n/a</ispartof><rights>2023 Wiley‐VHCA AG, Zurich, Switzerland</rights><rights>2023 Wiley-VHCA AG, Zurich, Switzerland.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3285-cf8458378b1db839cd6fbfeebab8e4b04ee943dd151f96a63d163db2bcf98cdc3</cites><orcidid>0000-0001-5429-0830 ; 0000-0002-2215-3900</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.202300115$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.202300115$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37236909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ammar Aldaddou, Wael</creatorcontrib><creatorcontrib>Aljohani, Abdullah S. M.</creatorcontrib><creatorcontrib>Adewale Ahmed, Idris</creatorcontrib><creatorcontrib>Al‐Wabel, Naser A.</creatorcontrib><creatorcontrib>El‐Ashmawy, Ibrahim M.</creatorcontrib><title>Salvia officinalis L. Methanolic Extract Reduces Lead and Nicotine‐Induced Sperm Quality Degeneration in Male Rats</title><title>Chemistry & biodiversity</title><addtitle>Chem Biodivers</addtitle><description>Most heavy metals and industrial chemicals such as nicotine and lead cause harm to the reproduction process through a decrease in sperm motility, fertilization process, and sperm binding to the oocyte. Salvia officinalis L. (sage) has been reported to enhance serum testosterone levels and other certain biochemical enzymes. Thus, the current study is aimed at evaluating the potential health benefits of S. officinalis L. methanol extract on lead and nicotine hydrogen tartrate‐induced sperm quality degeneration in male rats and also identifying some of the non‐polar volatile bioactive compounds that might be attributed to the bioactivity of S. officinalis extract using gas chromatography‐mass spectrometry (GC/MS). In the study, fifty‐four mature male albino rats of about 220–250 g [were divided randomly and equally into 9 groups (n=6)]. Sperm quality degeneration was induced through the oral administration of 1.5 g/L of lead acetate in drinking water or peritoneal injection of 0.50 mg/kg (animal weight) nicotine hydrogen tartrate for sixty days. Two doses (200 & 400 mg/kg b.w.) of S. officinalis L. were used. The rats were anesthetized after the experimental period and then sacrificed. Blood samples were collected while the epididymis, testicle, and accessory sex organs (prostates and seminal vesical) were taken for histopathological studies. Twelve major compounds were identified through the GC/MS analysis of S. officinalis L. methanol extract. Lead and nicotine toxicity had a great effect on the rats’ sperm quality causing a significant (p<0.05) decrease in the quantity of sperm and sperm motility as well as an upsurge in the abnormalities of the sperm and a reduction in the length & diameter of seminiferous tubules and size & weight of sexual organs (accessory sex glands, epididymis, and testis). The administration of S. officinalis L. methanol extract, however, had a positive impact on the sexual organ weights, semen quality & quantity, and rats’ fertility, thus, ameliorating the adversative effects of both lead and nicotine. Further evaluation and isolation of the bioactive components are recommended as potential drug leads.</description><subject>Abnormalities</subject><subject>Animals</subject><subject>Bioactive compounds</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Degeneration</subject><subject>Drinking water</subject><subject>Epididymis</subject><subject>Fertility</subject><subject>Fertilization</subject><subject>Gametocytes</subject><subject>Gas chromatography</subject><subject>Heavy metals</subject><subject>Hydrogen</subject><subject>lead</subject><subject>Lead acetates</subject><subject>Male</subject><subject>Males</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Methanol</subject><subject>Motility</subject><subject>Nicotine</subject><subject>Nicotine - pharmacology</subject><subject>Oral administration</subject><subject>Organs</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Salvia officinalis</subject><subject>Seeds</subject><subject>Semen</subject><subject>Semen Analysis</subject><subject>Sex</subject><subject>Sex glands</subject><subject>Sperm</subject><subject>Sperm Count - methods</subject><subject>Sperm Motility</subject><subject>sperm quality</subject><subject>Spermatozoa</subject><subject>Tartrates - pharmacology</subject><subject>Testosterone</subject><subject>Toxicity</subject><subject>Tubules</subject><issn>1612-1872</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1PGzEQhi1ERYBy7bGyxKWXpP7YbLzHNlBACqAmwHXljzEYbbyp7aXkxk_gN_aX1FFCKvXCwRpr5pnnMC9CnygZUELYV63M04ARxgmhdLiD9mlJWZ8KQXa3_xHroYMYHzOf-2IP9fiI8bIi1T5KM9k8OYlba512XjYu4skAX0J6kL5tnManzylInfAUTKchT0EaLL3BV063yXn48_J64Vczg2cLCHP8s8uatMQncA8egkyu9dh5fCkbwFOZ4kf0wcomwtGmHqLbH6c34_P-5PrsYvxt0teciWFfW1EMBR8JRY0SvNKmtMoCKKkEFIoUAFXBjaFDaqtSltzQ_BRT2lZCG80P0Ze1dxHaXx3EVM9d1NA00kPbxZoJlm9SlhXN6PF_6GPbhXyPFVUQWhSs5JkarCkd2hgD2HoR3FyGZU1JvcqjXuVRb_PIC5832k7NwWzxtwAyUK2B366B5Tu6evz95O6f_C_qXZi0</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Ammar Aldaddou, Wael</creator><creator>Aljohani, Abdullah S. M.</creator><creator>Adewale Ahmed, Idris</creator><creator>Al‐Wabel, Naser A.</creator><creator>El‐Ashmawy, Ibrahim M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5429-0830</orcidid><orcidid>https://orcid.org/0000-0002-2215-3900</orcidid></search><sort><creationdate>202307</creationdate><title>Salvia officinalis L. Methanolic Extract Reduces Lead and Nicotine‐Induced Sperm Quality Degeneration in Male Rats</title><author>Ammar Aldaddou, Wael ; Aljohani, Abdullah S. M. ; Adewale Ahmed, Idris ; Al‐Wabel, Naser A. ; El‐Ashmawy, Ibrahim M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3285-cf8458378b1db839cd6fbfeebab8e4b04ee943dd151f96a63d163db2bcf98cdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abnormalities</topic><topic>Animals</topic><topic>Bioactive compounds</topic><topic>Biocompatibility</topic><topic>Biological activity</topic><topic>Degeneration</topic><topic>Drinking water</topic><topic>Epididymis</topic><topic>Fertility</topic><topic>Fertilization</topic><topic>Gametocytes</topic><topic>Gas chromatography</topic><topic>Heavy metals</topic><topic>Hydrogen</topic><topic>lead</topic><topic>Lead acetates</topic><topic>Male</topic><topic>Males</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Methanol</topic><topic>Motility</topic><topic>Nicotine</topic><topic>Nicotine - pharmacology</topic><topic>Oral administration</topic><topic>Organs</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Salvia officinalis</topic><topic>Seeds</topic><topic>Semen</topic><topic>Semen Analysis</topic><topic>Sex</topic><topic>Sex glands</topic><topic>Sperm</topic><topic>Sperm Count - methods</topic><topic>Sperm Motility</topic><topic>sperm quality</topic><topic>Spermatozoa</topic><topic>Tartrates - pharmacology</topic><topic>Testosterone</topic><topic>Toxicity</topic><topic>Tubules</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ammar Aldaddou, Wael</creatorcontrib><creatorcontrib>Aljohani, Abdullah S. M.</creatorcontrib><creatorcontrib>Adewale Ahmed, Idris</creatorcontrib><creatorcontrib>Al‐Wabel, Naser A.</creatorcontrib><creatorcontrib>El‐Ashmawy, Ibrahim M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry & biodiversity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ammar Aldaddou, Wael</au><au>Aljohani, Abdullah S. M.</au><au>Adewale Ahmed, Idris</au><au>Al‐Wabel, Naser A.</au><au>El‐Ashmawy, Ibrahim M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salvia officinalis L. Methanolic Extract Reduces Lead and Nicotine‐Induced Sperm Quality Degeneration in Male Rats</atitle><jtitle>Chemistry & biodiversity</jtitle><addtitle>Chem Biodivers</addtitle><date>2023-07</date><risdate>2023</risdate><volume>20</volume><issue>7</issue><spage>e202300115</spage><epage>n/a</epage><pages>e202300115-n/a</pages><issn>1612-1872</issn><eissn>1612-1880</eissn><abstract>Most heavy metals and industrial chemicals such as nicotine and lead cause harm to the reproduction process through a decrease in sperm motility, fertilization process, and sperm binding to the oocyte. Salvia officinalis L. (sage) has been reported to enhance serum testosterone levels and other certain biochemical enzymes. Thus, the current study is aimed at evaluating the potential health benefits of S. officinalis L. methanol extract on lead and nicotine hydrogen tartrate‐induced sperm quality degeneration in male rats and also identifying some of the non‐polar volatile bioactive compounds that might be attributed to the bioactivity of S. officinalis extract using gas chromatography‐mass spectrometry (GC/MS). In the study, fifty‐four mature male albino rats of about 220–250 g [were divided randomly and equally into 9 groups (n=6)]. Sperm quality degeneration was induced through the oral administration of 1.5 g/L of lead acetate in drinking water or peritoneal injection of 0.50 mg/kg (animal weight) nicotine hydrogen tartrate for sixty days. Two doses (200 & 400 mg/kg b.w.) of S. officinalis L. were used. The rats were anesthetized after the experimental period and then sacrificed. Blood samples were collected while the epididymis, testicle, and accessory sex organs (prostates and seminal vesical) were taken for histopathological studies. Twelve major compounds were identified through the GC/MS analysis of S. officinalis L. methanol extract. Lead and nicotine toxicity had a great effect on the rats’ sperm quality causing a significant (p<0.05) decrease in the quantity of sperm and sperm motility as well as an upsurge in the abnormalities of the sperm and a reduction in the length & diameter of seminiferous tubules and size & weight of sexual organs (accessory sex glands, epididymis, and testis). The administration of S. officinalis L. methanol extract, however, had a positive impact on the sexual organ weights, semen quality & quantity, and rats’ fertility, thus, ameliorating the adversative effects of both lead and nicotine. Further evaluation and isolation of the bioactive components are recommended as potential drug leads.</abstract><cop>Switzerland</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37236909</pmid><doi>10.1002/cbdv.202300115</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5429-0830</orcidid><orcidid>https://orcid.org/0000-0002-2215-3900</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1612-1872 |
| ispartof | Chemistry & biodiversity, 2023-07, Vol.20 (7), p.e202300115-n/a |
| issn | 1612-1872 1612-1880 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2820026691 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Abnormalities Animals Bioactive compounds Biocompatibility Biological activity Degeneration Drinking water Epididymis Fertility Fertilization Gametocytes Gas chromatography Heavy metals Hydrogen lead Lead acetates Male Males Mass spectrometry Mass spectroscopy Methanol Motility Nicotine Nicotine - pharmacology Oral administration Organs Plant Extracts - pharmacology Rats Rats, Wistar Salvia officinalis Seeds Semen Semen Analysis Sex Sex glands Sperm Sperm Count - methods Sperm Motility sperm quality Spermatozoa Tartrates - pharmacology Testosterone Toxicity Tubules |
| title | Salvia officinalis L. Methanolic Extract Reduces Lead and Nicotine‐Induced Sperm Quality Degeneration in Male Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T13%3A19%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Salvia%20officinalis%20L.%20Methanolic%20Extract%20Reduces%20Lead%20and%20Nicotine%E2%80%90Induced%20Sperm%20Quality%20Degeneration%20in%20Male%20Rats&rft.jtitle=Chemistry%20&%20biodiversity&rft.au=Ammar%20Aldaddou,%20Wael&rft.date=2023-07&rft.volume=20&rft.issue=7&rft.spage=e202300115&rft.epage=n/a&rft.pages=e202300115-n/a&rft.issn=1612-1872&rft.eissn=1612-1880&rft_id=info:doi/10.1002/cbdv.202300115&rft_dat=%3Cproquest_cross%3E2820026691%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2840144263&rft_id=info:pmid/37236909&rfr_iscdi=true |