Alpha-1 antitrypsin deficiency and PiS and PiZ SERPINA1 variants are associated with asthma exacerbations

Asthma is a chronic inflammatory disease of the airways. Asthma patients may experience potentially life-threatening episodic flare-ups, known as exacerbations, which may significantly contribute to the asthma burden. The Pi*S and Pi*Z variants of the SERPINA1 gene, which usually involve alpha-1 ant...

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Veröffentlicht in:	Pulmonology 2025-12, Vol.31 (1), p.2416870
Hauptverfasser:	Martín-González, Elena, Hernández-Pérez, José M., Pérez, José A. Pérez, Pérez-García, Javier, Herrera-Luis, Esther, González-Pérez, Ruperto, González-González, Orelvis, Mederos-Luis, Elena, Sánchez-Machín, Inmaculada, Poza-Guedes, Paloma, Sardón, Olaia, Corcuera, Paula, Cruz, María J., González-Barcala, Francisco J., Martínez-Rivera, Carlos, Mullol, Joaquim, Muñoz, Xavier, Olaguibel, José M., Plaza, Vicente, Quirce, Santiago, Valero, Antonio, Sastre, Joaquín, Korta-Murua, Javier, del Pozo, Victoria, Lorenzo-Díaz, Fabián, Villar, Jesús, Pino-Yanes, María, González-Carracedo, Mario A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged alpha 1-Antitrypsin - blood alpha 1-Antitrypsin - genetics alpha 1-Antitrypsin Deficiency - complications alpha 1-Antitrypsin Deficiency - epidemiology alpha 1-Antitrypsin Deficiency - genetics Alpha-1 antitrypsin Alpha-1 antitrypsin deficiency Asthma Asthma - epidemiology Asthma - genetics Disease Progression Exacerbations Female Genetic Variation Genotype Humans Male Middle Aged SERPINA1 Spain - epidemiology
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