Mature tertiary lymphoid structures are key niches of tumour-specific immune responses in pancreatic ductal adenocarcinomas

ObjectiveTo better understand the immune microenvironment of pancreatic ductal adenocarcinomas (PDACs), here we explored the relevance of T and B cell compartmentalisation into tertiary lymphoid structures (TLSs) for the generation of local antitumour immunity.DesignWe characterised the functional s...

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Veröffentlicht in:	Gut 2023-10, Vol.72 (10), p.1927-1941
Hauptverfasser:	Kinker, Gabriela Sarti, Vitiello, Glauco Akelinghton Freire, Diniz, Ariane Barros, Cabral-Piccin, Mariela Pires, Pereira, Pedro Henrique Barbosa, Carvalho, Maria Letícia Rodrigues, Ferreira, Wallax Augusto Silva, Chaves, Alexandre Silva, Rondinelli, Amanda, Gusmão, Arianne Fagotti, Defelicibus, Alexandre, dos Santos, Gabriel Oliveira, Nunes, Warley Abreu, Claro, Laura Carolina López, Bernardo, Talita Magalhães, Nishio, Ricardo Tadashi, Pacheco, Adhemar Monteiro, Laus, Ana Carolina, Arantes, Lidia Maria Rebolho Batista, Fleck, Julia Lima, de Jesus, Victor Hugo Fonseca, de Moricz, André, Weinlich, Ricardo, Coimbra, Felipe José Fernandez, de Lima, Vladmir Cláudio Cordeiro, Medina, Tiago da Silva
Format:	Artikel
Sprache:	eng
Schlagworte:	Beta cells Biomarkers Biopsy Cancer Carcinoma, Pancreatic Ductal - genetics Cell differentiation Clinical trials CXCL13 protein Datasets Flow cytometry Gene expression Gene flow Genomes GI cancer Humans IMMUNE RESPONSE Immunity Immunofluorescence Immunotherapy Lymphocytes T Pancreas PANCREATIC CANCER Pancreatic Neoplasms Pancreatic Neoplasms - genetics Plasma cells T cell receptors Tertiary Lymphoid Structures - metabolism Tertiary Lymphoid Structures - pathology Transforming growth factor-b Tumor Microenvironment
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