Zoledronate Increases Bone Mineral Density in Nonambulant Children With Cerebral Palsy: A Randomized Controlled Trial

Abstract Context Zoledronate appears to reduce fracture rates in children with cerebral palsy (CP), but no previous randomized, controlled trial has been performed to compare the effect of zoledronate to placebo in children with CP. Objective To investigate the effect of zoledronate on bone mineral...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2023-11, Vol.108 (11), p.2840-2851
Hauptverfasser:	Granild-Jensen, Jakob Bie, Møller-Madsen, Bjarne, Rackauskaite, Gija, Farholt, Stense, Søndergaard, Charlotte, Sørensen, Tine Høg, Vestergaard, Esben Thyssen, Langdahl, Bente Lomholt
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemical markers Bone Density Bone Density Conservation Agents - adverse effects Bone mineral density Bones Cerebral palsied children Cerebral palsy Cerebral Palsy - drug therapy Child Children Clinical trials Density Developmental disabilities Diphosphonates - therapeutic use Disodium pamidronate Dual energy X-ray absorptiometry Femur Humans Imidazoles - adverse effects Lumbar Vertebrae - diagnostic imaging Osteoporosis Placebos Spine (lumbar) Standard scores Zoledronic acid Zoledronic Acid - therapeutic use
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