Immunohistochemical expression of cAMP in fluoroedenite‑induced malignant pleural mesothelioma: Preliminary results
Despite advances in understanding of the biology of malignant pleural mesothelioma (MPM), the prognosis of this malignancy remains poor. Although asbestos still remains the main pathogenic agent of MPM, other asbestos‑like fibers such as fluoro‑edenite (FE) fibers, induce MPM. Notable incidence and...
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| Veröffentlicht in: | Molecular medicine reports 2023-07, Vol.28 (1) |
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| creator | Broggi, Giuseppe Filetti, Veronica Magro, Gaetano Morante, Brunella Garro, Rossella Ledda, Caterina Rapisarda, Venerando Lombardo, Claudia Loreto, Carla Caltabiano, Rosario |
| description | Despite advances in understanding of the biology of malignant pleural mesothelioma (MPM), the prognosis of this malignancy remains poor. Although asbestos still remains the main pathogenic agent of MPM, other asbestos‑like fibers such as fluoro‑edenite (FE) fibers, induce MPM. Notable incidence and mortality rates of MPM have been found in Biancavilla, Italy, where FE fibers have been extracted from building materials for >50 years. Cyclic adenosine monophosphate (cAMP) is a secondary messenger that plays a key role in several physiological and pathological mechanisms regulating protein kinase A (PKA) and the CREB pathway. Hyperactivation of the cAMP/PKA/CREB pathway is involved in many neoplastic processes, including tumor cell proliferation, invasion and metastatic spread. The present study investigated immunohistochemical expression of cAMP in patients with FE‑induced MPM, which included six males and four females with an age range of 50‑93 years. There was high immunoexpression of cAMP in 5 out of 10 tumors while the remaining 5 cases showed low immunoexpression. In addition, there was a correlation between cAMP overexpression and decreased survival times (mean overall survival times, 7.5 months in high expression group vs. 18 months in low expression group). |
| doi_str_mv | 10.3892/mmr.2023.13019 |
| format | Article |
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Although asbestos still remains the main pathogenic agent of MPM, other asbestos‑like fibers such as fluoro‑edenite (FE) fibers, induce MPM. Notable incidence and mortality rates of MPM have been found in Biancavilla, Italy, where FE fibers have been extracted from building materials for >50 years. Cyclic adenosine monophosphate (cAMP) is a secondary messenger that plays a key role in several physiological and pathological mechanisms regulating protein kinase A (PKA) and the CREB pathway. Hyperactivation of the cAMP/PKA/CREB pathway is involved in many neoplastic processes, including tumor cell proliferation, invasion and metastatic spread. The present study investigated immunohistochemical expression of cAMP in patients with FE‑induced MPM, which included six males and four females with an age range of 50‑93 years. There was high immunoexpression of cAMP in 5 out of 10 tumors while the remaining 5 cases showed low immunoexpression. In addition, there was a correlation between cAMP overexpression and decreased survival times (mean overall survival times, 7.5 months in high expression group vs. 18 months in low expression group).</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2023.13019</identifier><identifier>PMID: 37232345</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Aged ; Aged, 80 and over ; AMP ; Androgens ; Apoptosis ; Asbestos ; Brain cancer ; Breast cancer ; Cell growth ; Cell proliferation ; Cyclic adenylic acid ; Cyclic AMP response element-binding protein ; Development and progression ; Environmental aspects ; Female ; Fibers ; Health aspects ; Humans ; Immunohistochemistry ; Kinases ; Lung Neoplasms - pathology ; Male ; Malignancy ; Measurement ; Medical prognosis ; Mesothelioma ; Mesothelioma - chemically induced ; Mesothelioma - metabolism ; Mesothelioma, Malignant ; Metastases ; Methods ; Middle Aged ; Morphology ; Phosphorylation ; Pleural diseases ; Prognosis ; Prostate ; Protein kinase A ; Proteins ; Statistical analysis ; Survival analysis ; Tumorigenesis ; Tumors</subject><ispartof>Molecular medicine reports, 2023-07, Vol.28 (1)</ispartof><rights>COPYRIGHT 2023 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2023</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37232345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Broggi, Giuseppe</creatorcontrib><creatorcontrib>Filetti, Veronica</creatorcontrib><creatorcontrib>Magro, Gaetano</creatorcontrib><creatorcontrib>Morante, Brunella</creatorcontrib><creatorcontrib>Garro, Rossella</creatorcontrib><creatorcontrib>Ledda, Caterina</creatorcontrib><creatorcontrib>Rapisarda, Venerando</creatorcontrib><creatorcontrib>Lombardo, Claudia</creatorcontrib><creatorcontrib>Loreto, Carla</creatorcontrib><creatorcontrib>Caltabiano, Rosario</creatorcontrib><title>Immunohistochemical expression of cAMP in fluoroedenite‑induced malignant pleural mesothelioma: Preliminary results</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Despite advances in understanding of the biology of malignant pleural mesothelioma (MPM), the prognosis of this malignancy remains poor. 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In addition, there was a correlation between cAMP overexpression and decreased survival times (mean overall survival times, 7.5 months in high expression group vs. 18 months in low expression group).</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>AMP</subject><subject>Androgens</subject><subject>Apoptosis</subject><subject>Asbestos</subject><subject>Brain cancer</subject><subject>Breast cancer</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Cyclic adenylic acid</subject><subject>Cyclic AMP response element-binding protein</subject><subject>Development and progression</subject><subject>Environmental aspects</subject><subject>Female</subject><subject>Fibers</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kinases</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Malignancy</subject><subject>Measurement</subject><subject>Medical prognosis</subject><subject>Mesothelioma</subject><subject>Mesothelioma - 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Academic</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Broggi, Giuseppe</au><au>Filetti, Veronica</au><au>Magro, Gaetano</au><au>Morante, Brunella</au><au>Garro, Rossella</au><au>Ledda, Caterina</au><au>Rapisarda, Venerando</au><au>Lombardo, Claudia</au><au>Loreto, Carla</au><au>Caltabiano, Rosario</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical expression of cAMP in fluoroedenite‑induced malignant pleural mesothelioma: Preliminary results</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>28</volume><issue>1</issue><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Despite advances in understanding of the biology of malignant pleural mesothelioma (MPM), the prognosis of this malignancy remains poor. Although asbestos still remains the main pathogenic agent of MPM, other asbestos‑like fibers such as fluoro‑edenite (FE) fibers, induce MPM. Notable incidence and mortality rates of MPM have been found in Biancavilla, Italy, where FE fibers have been extracted from building materials for >50 years. Cyclic adenosine monophosphate (cAMP) is a secondary messenger that plays a key role in several physiological and pathological mechanisms regulating protein kinase A (PKA) and the CREB pathway. Hyperactivation of the cAMP/PKA/CREB pathway is involved in many neoplastic processes, including tumor cell proliferation, invasion and metastatic spread. The present study investigated immunohistochemical expression of cAMP in patients with FE‑induced MPM, which included six males and four females with an age range of 50‑93 years. There was high immunoexpression of cAMP in 5 out of 10 tumors while the remaining 5 cases showed low immunoexpression. In addition, there was a correlation between cAMP overexpression and decreased survival times (mean overall survival times, 7.5 months in high expression group vs. 18 months in low expression group).</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>37232345</pmid><doi>10.3892/mmr.2023.13019</doi></addata></record> |
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| subjects | Aged Aged, 80 and over AMP Androgens Apoptosis Asbestos Brain cancer Breast cancer Cell growth Cell proliferation Cyclic adenylic acid Cyclic AMP response element-binding protein Development and progression Environmental aspects Female Fibers Health aspects Humans Immunohistochemistry Kinases Lung Neoplasms - pathology Male Malignancy Measurement Medical prognosis Mesothelioma Mesothelioma - chemically induced Mesothelioma - metabolism Mesothelioma, Malignant Metastases Methods Middle Aged Morphology Phosphorylation Pleural diseases Prognosis Prostate Protein kinase A Proteins Statistical analysis Survival analysis Tumorigenesis Tumors |
| title | Immunohistochemical expression of cAMP in fluoroedenite‑induced malignant pleural mesothelioma: Preliminary results |
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