Stability of 20S Proteasome Configurations: Preopening the Axial Gate

Mass spectrometry studies of the stability of the S. cerevisiae 20S proteasome from 11 to 55 °C reveal a series of related configurations and coupled transitions that appear to be associated with opening of the proteolytic core. We find no evidence for dissociation, and all transitions are reversibl...

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Veröffentlicht in:	The journal of physical chemistry letters 2023-06, Vol.14 (21), p.5014-5017
Hauptverfasser:	Henderson, Lucas W., Sharon, Edie M., Gautam, Amit K. S., Anthony, Adam J., Jarrold, Martin F., Russell, David H., Matouschek, Andreas, Clemmer, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Physical Insights into Chemistry, Catalysis, and Interfaces Proteasome Endopeptidase Complex - chemistry Proteasome Endopeptidase Complex - metabolism Proteolysis Saccharomyces cerevisiae - metabolism
Online-Zugang:	Volltext
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