Carbon monoxide as a clinical marker of hemolysis

Carbon monoxide as a clinical marker of hemolysis

Carbon monoxide (CO)‐based tests have precisely measured hemolysis for over 40 years. End‐tidal CO was the primary marker in clinical hematology research, followed by carboxyhemoglobin. Quantification of CO reflects heme oxygenases degrading heme in a 1:1 stoichiometric ratio, making CO a direct mar...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of hematology 2023-07, Vol.98 (7), p.1127-1159
Hauptverfasser: Osborne, Jake, Sobh, Mohamad, Trudel, Guy
Format: Artikel
Sprache:eng
Schlagworte:
Alveoli
Carbon monoxide
Carboxyhemoglobin
Gas chromatography
Hematology
Hematoma
Heme
Hemolysis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1159
container_issue 7
container_start_page 1127
container_title American journal of hematology
container_volume 98
creator Osborne, Jake
Sobh, Mohamad
Trudel, Guy
description Carbon monoxide (CO)‐based tests have precisely measured hemolysis for over 40 years. End‐tidal CO was the primary marker in clinical hematology research, followed by carboxyhemoglobin. Quantification of CO reflects heme oxygenases degrading heme in a 1:1 stoichiometric ratio, making CO a direct marker of hemolysis. CO in alveolar air can be quantified using gas chromatography, whose high resolution allows detecting mild and moderate levels of hemolysis. CO can be elevated in active bleeding, resorbing hematoma, and smoking. Clinical acumen and other markers remain necessary to diagnose the cause of hemolysis. CO‐based tests constitute an opportunity for bench‐to‐bedside technology transfer.
doi_str_mv 10.1002/ajh.26958
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2819277753</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2825059896</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3138-56da5c7ba8dc06092a135f32485f343b3e84a49f94832316e341da5aaa7259633</originalsourceid><addsrcrecordid>eNp1kD1PwzAQhi0EoqUw8AdQJBYY0vo79lhVfKoSC8zWJXHUlCQuNhH03-OSwoDEcnfDc4_uXoTOCZ4SjOkM1qsplVqoAzQmWMtUSUEP0RgzSeKM9QidhLDGmBCu8DEasYxSqZQaI7IAn7suaV3nPuvSJhASSIqm7uoCmqQF_2p94qpkZVvXbEMdTtFRBU2wZ_s-QS-3N8-L-3T5dPewmC_TghGmUiFLEEWWgyoLHE-gQJioGOUqVs5yZhUHrivNFaOMSMs4iRsAkFGhJWMTdDV4N9699Ta8m7YOhW0a6Kzrg6GKaJplmdihl3_Qtet9F6-LFBVYaBWNE3Q9UIV3IXhbmY2v44NbQ7DZ5WhijuY7x8he7I193tryl_wJLgKzAfioG7v932Tmj_eD8gvvgXkU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2825059896</pqid></control><display><type>article</type><title>Carbon monoxide as a clinical marker of hemolysis</title><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Osborne, Jake ; Sobh, Mohamad ; Trudel, Guy</creator><creatorcontrib>Osborne, Jake ; Sobh, Mohamad ; Trudel, Guy</creatorcontrib><description>Carbon monoxide (CO)‐based tests have precisely measured hemolysis for over 40 years. End‐tidal CO was the primary marker in clinical hematology research, followed by carboxyhemoglobin. Quantification of CO reflects heme oxygenases degrading heme in a 1:1 stoichiometric ratio, making CO a direct marker of hemolysis. CO in alveolar air can be quantified using gas chromatography, whose high resolution allows detecting mild and moderate levels of hemolysis. CO can be elevated in active bleeding, resorbing hematoma, and smoking. Clinical acumen and other markers remain necessary to diagnose the cause of hemolysis. CO‐based tests constitute an opportunity for bench‐to‐bedside technology transfer.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.26958</identifier><identifier>PMID: 37226888</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley &amp; Sons, Inc</publisher><subject>Alveoli ; Carbon monoxide ; Carboxyhemoglobin ; Gas chromatography ; Hematology ; Hematoma ; Heme ; Hemolysis</subject><ispartof>American journal of hematology, 2023-07, Vol.98 (7), p.1127-1159</ispartof><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3138-56da5c7ba8dc06092a135f32485f343b3e84a49f94832316e341da5aaa7259633</cites><orcidid>0000-0001-5254-4294 ; 0000-0003-0164-7490</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajh.26958$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajh.26958$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37226888$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Osborne, Jake</creatorcontrib><creatorcontrib>Sobh, Mohamad</creatorcontrib><creatorcontrib>Trudel, Guy</creatorcontrib><title>Carbon monoxide as a clinical marker of hemolysis</title><title>American journal of hematology</title><addtitle>Am J Hematol</addtitle><description>Carbon monoxide (CO)‐based tests have precisely measured hemolysis for over 40 years. End‐tidal CO was the primary marker in clinical hematology research, followed by carboxyhemoglobin. Quantification of CO reflects heme oxygenases degrading heme in a 1:1 stoichiometric ratio, making CO a direct marker of hemolysis. CO in alveolar air can be quantified using gas chromatography, whose high resolution allows detecting mild and moderate levels of hemolysis. CO can be elevated in active bleeding, resorbing hematoma, and smoking. Clinical acumen and other markers remain necessary to diagnose the cause of hemolysis. CO‐based tests constitute an opportunity for bench‐to‐bedside technology transfer.</description><subject>Alveoli</subject><subject>Carbon monoxide</subject><subject>Carboxyhemoglobin</subject><subject>Gas chromatography</subject><subject>Hematology</subject><subject>Hematoma</subject><subject>Heme</subject><subject>Hemolysis</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kD1PwzAQhi0EoqUw8AdQJBYY0vo79lhVfKoSC8zWJXHUlCQuNhH03-OSwoDEcnfDc4_uXoTOCZ4SjOkM1qsplVqoAzQmWMtUSUEP0RgzSeKM9QidhLDGmBCu8DEasYxSqZQaI7IAn7suaV3nPuvSJhASSIqm7uoCmqQF_2p94qpkZVvXbEMdTtFRBU2wZ_s-QS-3N8-L-3T5dPewmC_TghGmUiFLEEWWgyoLHE-gQJioGOUqVs5yZhUHrivNFaOMSMs4iRsAkFGhJWMTdDV4N9699Ta8m7YOhW0a6Kzrg6GKaJplmdihl3_Qtet9F6-LFBVYaBWNE3Q9UIV3IXhbmY2v44NbQ7DZ5WhijuY7x8he7I193tryl_wJLgKzAfioG7v932Tmj_eD8gvvgXkU</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Osborne, Jake</creator><creator>Sobh, Mohamad</creator><creator>Trudel, Guy</creator><general>John Wiley &amp; Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5254-4294</orcidid><orcidid>https://orcid.org/0000-0003-0164-7490</orcidid></search><sort><creationdate>202307</creationdate><title>Carbon monoxide as a clinical marker of hemolysis</title><author>Osborne, Jake ; Sobh, Mohamad ; Trudel, Guy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3138-56da5c7ba8dc06092a135f32485f343b3e84a49f94832316e341da5aaa7259633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alveoli</topic><topic>Carbon monoxide</topic><topic>Carboxyhemoglobin</topic><topic>Gas chromatography</topic><topic>Hematology</topic><topic>Hematoma</topic><topic>Heme</topic><topic>Hemolysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Osborne, Jake</creatorcontrib><creatorcontrib>Sobh, Mohamad</creatorcontrib><creatorcontrib>Trudel, Guy</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osborne, Jake</au><au>Sobh, Mohamad</au><au>Trudel, Guy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbon monoxide as a clinical marker of hemolysis</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>2023-07</date><risdate>2023</risdate><volume>98</volume><issue>7</issue><spage>1127</spage><epage>1159</epage><pages>1127-1159</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><abstract>Carbon monoxide (CO)‐based tests have precisely measured hemolysis for over 40 years. End‐tidal CO was the primary marker in clinical hematology research, followed by carboxyhemoglobin. Quantification of CO reflects heme oxygenases degrading heme in a 1:1 stoichiometric ratio, making CO a direct marker of hemolysis. CO in alveolar air can be quantified using gas chromatography, whose high resolution allows detecting mild and moderate levels of hemolysis. CO can be elevated in active bleeding, resorbing hematoma, and smoking. Clinical acumen and other markers remain necessary to diagnose the cause of hemolysis. CO‐based tests constitute an opportunity for bench‐to‐bedside technology transfer.</abstract><cop>Hoboken, USA</cop><pub>John Wiley &amp; Sons, Inc</pub><pmid>37226888</pmid><doi>10.1002/ajh.26958</doi><tpages>33</tpages><orcidid>https://orcid.org/0000-0001-5254-4294</orcidid><orcidid>https://orcid.org/0000-0003-0164-7490</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0361-8609
ispartof American journal of hematology, 2023-07, Vol.98 (7), p.1127-1159
issn 0361-8609
1096-8652
language eng
recordid cdi_proquest_miscellaneous_2819277753
source Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Alveoli
Carbon monoxide
Carboxyhemoglobin
Gas chromatography
Hematology
Hematoma
Heme
Hemolysis
title Carbon monoxide as a clinical marker of hemolysis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T09%3A32%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Carbon%20monoxide%20as%20a%20clinical%20marker%20of%20hemolysis&rft.jtitle=American%20journal%20of%20hematology&rft.au=Osborne,%20Jake&rft.date=2023-07&rft.volume=98&rft.issue=7&rft.spage=1127&rft.epage=1159&rft.pages=1127-1159&rft.issn=0361-8609&rft.eissn=1096-8652&rft_id=info:doi/10.1002/ajh.26958&rft_dat=%3Cproquest_cross%3E2825059896%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2825059896&rft_id=info:pmid/37226888&rfr_iscdi=true