Design and Optimization of Novel Benzimidazole- and Imidazo[4,5‑b]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities

The ATM kinase is a promising target in cancer treatment as an important regulator of the cellular response to DNA double-strand breaks. In this work, we present a new class of specific benzimidazole-based ATM inhibitors with picomolar potency against the isolated enzyme and favorable selectivity wi...

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Veröffentlicht in:	Journal of medicinal chemistry 2023-06, Vol.66 (11), p.7304-7330
Hauptverfasser:	Dimitrov, Teodor, Moschopoulou, Athina Anastasia, Seidel, Lennart, Kronenberger, Thales, Kudolo, Mark, Poso, Antti, Geibel, Christian, Wölffing, Pascal, Dauch, Daniel, Zender, Lars, Schollmeyer, Dieter, Bajorath, Jürgen, Forster, Michael, Laufer, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Mutated Proteins Benzimidazoles - pharmacology Etoposide Humans Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Pyridines - pharmacology
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