Upregulation of helicase-like transcription factor predicts poor prognosis and facilitates hepatocellular carcinoma progression
Helicase-like transcription factor (HLTF) belongs to the family of SWI/SNF proteins, which has been reported to exert oncogenic function in several human cancers. However, to date, its functional role in hepatocellular carcinoma (HCC) has not been revealed. Here, we found that HLTF was highly expres...
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| Veröffentlicht in: | Human cell : official journal of Human Cell Research Society 2023-07, Vol.36 (4), p.1477-1484 |
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| container_title | Human cell : official journal of Human Cell Research Society |
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| creator | Cen, Xuesong Lu, Yuyan Lu, Jing Zhan, Ping Cheng, Yizhe Luo, Changhong Liu, Jie Xie, Chengrong Wang, Fuqiang |
| description | Helicase-like transcription factor (HLTF) belongs to the family of SWI/SNF proteins, which has been reported to exert oncogenic function in several human cancers. However, to date, its functional role in hepatocellular carcinoma (HCC) has not been revealed. Here, we found that HLTF was highly expressed in HCC tissues compared to nontumor tissues. Additionally, upregulation of HLTF was significantly associated with poor prognosis of patients with HCC. Functional experiments demonstrated that knockdown of HLTF expression significantly inhibited the proliferation, migration, and invasion of HCC cells in vitro, and suppressed tumor growth in vivo. In conclusion, our results suggest that upregulation of HLTF is associated with the development of HCC, and HLTF may be a potential therapeutic target for HCC treatment. |
| doi_str_mv | 10.1007/s13577-023-00917-3 |
| format | Article |
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However, to date, its functional role in hepatocellular carcinoma (HCC) has not been revealed. Here, we found that HLTF was highly expressed in HCC tissues compared to nontumor tissues. Additionally, upregulation of HLTF was significantly associated with poor prognosis of patients with HCC. Functional experiments demonstrated that knockdown of HLTF expression significantly inhibited the proliferation, migration, and invasion of HCC cells in vitro, and suppressed tumor growth in vivo. In conclusion, our results suggest that upregulation of HLTF is associated with the development of HCC, and HLTF may be a potential therapeutic target for HCC treatment.</description><identifier>ISSN: 1749-0774</identifier><identifier>ISSN: 0914-7470</identifier><identifier>EISSN: 1749-0774</identifier><identifier>DOI: 10.1007/s13577-023-00917-3</identifier><identifier>PMID: 37227687</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Biomedical and Life Sciences ; Cell Biology ; Cell proliferation ; DNA helicase ; Gynecology ; Hepatocellular carcinoma ; Life Sciences ; Oncology ; Prognosis ; Reproductive Medicine ; Research Article ; Stem Cells ; Surgery ; Therapeutic targets ; Up-regulation</subject><ispartof>Human cell : official journal of Human Cell Research Society, 2023-07, Vol.36 (4), p.1477-1484</ispartof><rights>The Author(s) under exclusive licence to Japan Human Cell Society 2023. 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However, to date, its functional role in hepatocellular carcinoma (HCC) has not been revealed. Here, we found that HLTF was highly expressed in HCC tissues compared to nontumor tissues. Additionally, upregulation of HLTF was significantly associated with poor prognosis of patients with HCC. Functional experiments demonstrated that knockdown of HLTF expression significantly inhibited the proliferation, migration, and invasion of HCC cells in vitro, and suppressed tumor growth in vivo. In conclusion, our results suggest that upregulation of HLTF is associated with the development of HCC, and HLTF may be a potential therapeutic target for HCC treatment.</description><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cell proliferation</subject><subject>DNA helicase</subject><subject>Gynecology</subject><subject>Hepatocellular carcinoma</subject><subject>Life Sciences</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Reproductive Medicine</subject><subject>Research Article</subject><subject>Stem Cells</subject><subject>Surgery</subject><subject>Therapeutic targets</subject><subject>Up-regulation</subject><issn>1749-0774</issn><issn>0914-7470</issn><issn>1749-0774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kT1PwzAQhi0EolD4AwwoEgtLwI7dOB4R4ktCYoHZcpxLcUnj4HMGJv46bsuXGJh81j3ve6d7CTli9IxRKs-R8ZmUOS14TqliMudbZI9JoXIqpdj-VU_IPuKCUjETZbFLJlwWhSwruUfen4YA87Ez0fk-8232DJ2zBiHv3AtkMZgebXDDut0aG33IkqJxNmI2-PXPz3uPDjPTNyvEdS6aCJisBhO9ha5L_iGzJljX-6VZSwIgJs8DstOaDuHw852Sp-urx8vb_P7h5u7y4j63XKmYi6rhypSyri2YSqSigbYVgtXWQq245QIULVXdlKVgbQVGFEIZsILZupm1fEpON75p9usIGPXS4Wo104MfURcVU-kklFUJPfmDLvwY-rRdoopK0HRHmqhiQ9ngEQO0eghuacKbZlSv4tGbeHSKR6_j0TyJjj-tx3oJzbfkK48E8A2AqdXPIfzM_sf2A7Nyn1A</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Cen, Xuesong</creator><creator>Lu, Yuyan</creator><creator>Lu, Jing</creator><creator>Zhan, Ping</creator><creator>Cheng, Yizhe</creator><creator>Luo, Changhong</creator><creator>Liu, Jie</creator><creator>Xie, Chengrong</creator><creator>Wang, Fuqiang</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230701</creationdate><title>Upregulation of helicase-like transcription factor predicts poor prognosis and facilitates hepatocellular carcinoma progression</title><author>Cen, Xuesong ; Lu, Yuyan ; Lu, Jing ; Zhan, Ping ; Cheng, Yizhe ; Luo, Changhong ; Liu, Jie ; Xie, Chengrong ; Wang, Fuqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-48d39a67bbcea8467bdeff441bcceb93c34e9069bd6641f8ea4249aec41cbd5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Cell proliferation</topic><topic>DNA helicase</topic><topic>Gynecology</topic><topic>Hepatocellular carcinoma</topic><topic>Life Sciences</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Reproductive Medicine</topic><topic>Research Article</topic><topic>Stem Cells</topic><topic>Surgery</topic><topic>Therapeutic targets</topic><topic>Up-regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cen, Xuesong</creatorcontrib><creatorcontrib>Lu, Yuyan</creatorcontrib><creatorcontrib>Lu, Jing</creatorcontrib><creatorcontrib>Zhan, Ping</creatorcontrib><creatorcontrib>Cheng, Yizhe</creatorcontrib><creatorcontrib>Luo, Changhong</creatorcontrib><creatorcontrib>Liu, Jie</creatorcontrib><creatorcontrib>Xie, Chengrong</creatorcontrib><creatorcontrib>Wang, Fuqiang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human cell : official journal of Human Cell Research Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cen, Xuesong</au><au>Lu, Yuyan</au><au>Lu, Jing</au><au>Zhan, Ping</au><au>Cheng, Yizhe</au><au>Luo, Changhong</au><au>Liu, Jie</au><au>Xie, Chengrong</au><au>Wang, Fuqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Upregulation of helicase-like transcription factor predicts poor prognosis and facilitates hepatocellular carcinoma progression</atitle><jtitle>Human cell : official journal of Human Cell Research Society</jtitle><stitle>Human Cell</stitle><addtitle>Hum Cell</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>36</volume><issue>4</issue><spage>1477</spage><epage>1484</epage><pages>1477-1484</pages><issn>1749-0774</issn><issn>0914-7470</issn><eissn>1749-0774</eissn><abstract>Helicase-like transcription factor (HLTF) belongs to the family of SWI/SNF proteins, which has been reported to exert oncogenic function in several human cancers. 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| subjects | Biomedical and Life Sciences Cell Biology Cell proliferation DNA helicase Gynecology Hepatocellular carcinoma Life Sciences Oncology Prognosis Reproductive Medicine Research Article Stem Cells Surgery Therapeutic targets Up-regulation |
| title | Upregulation of helicase-like transcription factor predicts poor prognosis and facilitates hepatocellular carcinoma progression |
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