Dynorphin 1-17 biotransformation peptides: properties, challenges and solutions for future therapeutics development

It is well established that endogenously produced dynorphin 1-17 (DYN 1-17) is susceptible to enzymatic degradation, producing a variety of unique fragments in different tissue matrices and disease pathologies. DYN 1-17 and its major biotransformation fragments have significant roles in neurological...

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Veröffentlicht in:	Future medicinal chemistry 2023-05, Vol.15 (9), p.791-808
Hauptverfasser:	Ballouze, Rama, Salhimi, Salizawati Muhamad, Mohtar, Noratiqah, Fazalul Rahiman, Siti Sarah
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid Biotransformation dynorphin analogues Dynorphins - metabolism Dynorphins - pharmacology endogenous opioids enzymatic degradation inflammation neurological disorders opioid receptors Peptide Fragments - metabolism peptide nanoformulation Peptides - metabolism Peptides - pharmacology
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