Monoacylglycerol Lipase Inhibitor JJKK048 Ameliorates ABCG2 Transporter-Mediated Regorafenib Resistance Induced by Hypoxia in Triple Negative Breast Cancer Cells

Triple negative breast cancer (TNBC) is among the most aggressive and deadly cancer subtypes. Intra-tumoral hypoxia is associated with aggressiveness and drug resistance in TNBC. One of the underlying mechanisms of hypoxia-induced drug resistance is the elevated expression of efflux transporters suc...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2023-09, Vol.112 (9), p.2581-2590
Hauptverfasser:	Puris, Elena, Petralla, Sabrina, Auriola, Seppo, Kidron, Heidi, Fricker, Gert, Gynther, Mikko
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-cancer drug resistance ATP Binding Cassette Transporter, Subfamily G, Member 2 - metabolism Breast cancer resistance protein Cell Line, Tumor Drug Resistance, Neoplasm Humans Hypoxia Monoacylglycerol lipase Monoacylglycerol Lipases - metabolism Monoacylglycerol Lipases - pharmacology Neoplasm Proteins - metabolism Piperidines - pharmacology Piperidines - therapeutic use Triazoles - pharmacology Triazoles - therapeutic use Triple negative breast cancer Triple Negative Breast Neoplasms - drug therapy
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