Age-associated change in pyruvate metabolism investigated with hyperpolarized 13 C-MRI of the human brain
In this study, hyperpolarized C MRI (HP- C MRI) was used to investigate changes in the uptake and metabolism of pyruvate with age. Hyperpolarized C-pyruvate was administered to healthy aging individuals (N = 35, ages 21-77) and whole-brain spatial distributions of C-lactate and C-bicarbonate product...
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| Veröffentlicht in: | Human brain mapping 2023-07, Vol.44 (10), p.4052-4063 |
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| creator | Uthayakumar, Biranavan Soliman, Hany Bragagnolo, Nadia D Cappelletto, Nicole I C Lee, Casey Y Geraghty, Benjamin Chen, Albert P Perks, William J Ma, Nathan Heyn, Chris Endre, Ruby MacIntosh, Bradley J Stanisz, Greg J Black, Sandra E Cunningham, Charles H |
| description | In this study, hyperpolarized
C MRI (HP-
C MRI) was used to investigate changes in the uptake and metabolism of pyruvate with age. Hyperpolarized
C-pyruvate was administered to healthy aging individuals (N = 35, ages 21-77) and whole-brain spatial distributions of
C-lactate and
C-bicarbonate production were measured. Linear mixed-effects regressions were performed to compute the regional percentage change per decade, showing a significant reduction in both normalized
C-lactate and normalized
C-bicarbonate production with age:
per decade for
C-lactate and
per decade for
C-bicarbonate. Certain regions, such as the right medial precentral gyrus, showed greater rates of change while the left caudate nucleus had a flat
C-lactate versus age and a slightly increasing
C-bicarbonate versus age. The results show that both the production of lactate (visible as
C-lactate signal) as well as the consumption of monocarboxylates to make acetyl-CoA (visible as
C-bicarbonate signal) decrease with age and that the rate of change varies by brain region. |
| doi_str_mv | 10.1002/hbm.26329 |
| format | Article |
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C MRI (HP-
C MRI) was used to investigate changes in the uptake and metabolism of pyruvate with age. Hyperpolarized
C-pyruvate was administered to healthy aging individuals (N = 35, ages 21-77) and whole-brain spatial distributions of
C-lactate and
C-bicarbonate production were measured. Linear mixed-effects regressions were performed to compute the regional percentage change per decade, showing a significant reduction in both normalized
C-lactate and normalized
C-bicarbonate production with age:
per decade for
C-lactate and
per decade for
C-bicarbonate. Certain regions, such as the right medial precentral gyrus, showed greater rates of change while the left caudate nucleus had a flat
C-lactate versus age and a slightly increasing
C-bicarbonate versus age. The results show that both the production of lactate (visible as
C-lactate signal) as well as the consumption of monocarboxylates to make acetyl-CoA (visible as
C-bicarbonate signal) decrease with age and that the rate of change varies by brain region.</description><identifier>ISSN: 1065-9471</identifier><identifier>EISSN: 1097-0193</identifier><identifier>DOI: 10.1002/hbm.26329</identifier><identifier>PMID: 37219519</identifier><language>eng</language><publisher>United States</publisher><subject>Bicarbonates - metabolism ; Brain - diagnostic imaging ; Brain - metabolism ; Carbon Isotopes - metabolism ; Humans ; Lactic Acid - metabolism ; Magnetic Resonance Imaging - methods ; Pyruvic Acid - metabolism</subject><ispartof>Human brain mapping, 2023-07, Vol.44 (10), p.4052-4063</ispartof><rights>2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1309-3a6beecea375cea2e4ca8403d1d08d95346190081edd883b085fe8a467a866163</citedby><cites>FETCH-LOGICAL-c1309-3a6beecea375cea2e4ca8403d1d08d95346190081edd883b085fe8a467a866163</cites><orcidid>0000-0001-9636-8130 ; 0000-0001-7300-2355</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37219519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uthayakumar, Biranavan</creatorcontrib><creatorcontrib>Soliman, Hany</creatorcontrib><creatorcontrib>Bragagnolo, Nadia D</creatorcontrib><creatorcontrib>Cappelletto, Nicole I C</creatorcontrib><creatorcontrib>Lee, Casey Y</creatorcontrib><creatorcontrib>Geraghty, Benjamin</creatorcontrib><creatorcontrib>Chen, Albert P</creatorcontrib><creatorcontrib>Perks, William J</creatorcontrib><creatorcontrib>Ma, Nathan</creatorcontrib><creatorcontrib>Heyn, Chris</creatorcontrib><creatorcontrib>Endre, Ruby</creatorcontrib><creatorcontrib>MacIntosh, Bradley J</creatorcontrib><creatorcontrib>Stanisz, Greg J</creatorcontrib><creatorcontrib>Black, Sandra E</creatorcontrib><creatorcontrib>Cunningham, Charles H</creatorcontrib><title>Age-associated change in pyruvate metabolism investigated with hyperpolarized 13 C-MRI of the human brain</title><title>Human brain mapping</title><addtitle>Hum Brain Mapp</addtitle><description>In this study, hyperpolarized
C MRI (HP-
C MRI) was used to investigate changes in the uptake and metabolism of pyruvate with age. Hyperpolarized
C-pyruvate was administered to healthy aging individuals (N = 35, ages 21-77) and whole-brain spatial distributions of
C-lactate and
C-bicarbonate production were measured. Linear mixed-effects regressions were performed to compute the regional percentage change per decade, showing a significant reduction in both normalized
C-lactate and normalized
C-bicarbonate production with age:
per decade for
C-lactate and
per decade for
C-bicarbonate. Certain regions, such as the right medial precentral gyrus, showed greater rates of change while the left caudate nucleus had a flat
C-lactate versus age and a slightly increasing
C-bicarbonate versus age. The results show that both the production of lactate (visible as
C-lactate signal) as well as the consumption of monocarboxylates to make acetyl-CoA (visible as
C-bicarbonate signal) decrease with age and that the rate of change varies by brain region.</description><subject>Bicarbonates - metabolism</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Carbon Isotopes - metabolism</subject><subject>Humans</subject><subject>Lactic Acid - metabolism</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Pyruvic Acid - metabolism</subject><issn>1065-9471</issn><issn>1097-0193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1Lw0AQhhdRtFYP_gHZox6iM9lks3ssxS-oCKLnsEmmzUq-3E0q9deb2uplZnh5eBkexi4QbhAgvC2z-iaUItQHbIKgkwBQi8PtLeNARwmesFPvPwAQY8BjdiKSEHWMesLsbEWB8b7Nremp4HlpmhVx2_Bu44b1mPGaepO1lfX1GK_J93b1i37ZvuTlpiPXtZVx9nvMUPB58Pz6xNsl70vi5VCbhmfO2OaMHS1N5el8v6fs_f7ubf4YLF4enuazRZCjAB0IIzOinIxI4nGGFOVGRSAKLEAVOhaRRA2gkIpCKZGBipekTCQTo6REKabsatfbufZzGN9Na-tzqirTUDv4NFSoQEIcbtHrHZq71ntHy7RztjZukyKkW7PpaDb9NTuyl_vaIaup-Cf_VIofNUhzww</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Uthayakumar, Biranavan</creator><creator>Soliman, Hany</creator><creator>Bragagnolo, Nadia D</creator><creator>Cappelletto, Nicole I C</creator><creator>Lee, Casey Y</creator><creator>Geraghty, Benjamin</creator><creator>Chen, Albert P</creator><creator>Perks, William J</creator><creator>Ma, Nathan</creator><creator>Heyn, Chris</creator><creator>Endre, Ruby</creator><creator>MacIntosh, Bradley J</creator><creator>Stanisz, Greg J</creator><creator>Black, Sandra E</creator><creator>Cunningham, Charles H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9636-8130</orcidid><orcidid>https://orcid.org/0000-0001-7300-2355</orcidid></search><sort><creationdate>202307</creationdate><title>Age-associated change in pyruvate metabolism investigated with hyperpolarized 13 C-MRI of the human brain</title><author>Uthayakumar, Biranavan ; 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C MRI (HP-
C MRI) was used to investigate changes in the uptake and metabolism of pyruvate with age. Hyperpolarized
C-pyruvate was administered to healthy aging individuals (N = 35, ages 21-77) and whole-brain spatial distributions of
C-lactate and
C-bicarbonate production were measured. Linear mixed-effects regressions were performed to compute the regional percentage change per decade, showing a significant reduction in both normalized
C-lactate and normalized
C-bicarbonate production with age:
per decade for
C-lactate and
per decade for
C-bicarbonate. Certain regions, such as the right medial precentral gyrus, showed greater rates of change while the left caudate nucleus had a flat
C-lactate versus age and a slightly increasing
C-bicarbonate versus age. The results show that both the production of lactate (visible as
C-lactate signal) as well as the consumption of monocarboxylates to make acetyl-CoA (visible as
C-bicarbonate signal) decrease with age and that the rate of change varies by brain region.</abstract><cop>United States</cop><pmid>37219519</pmid><doi>10.1002/hbm.26329</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-9636-8130</orcidid><orcidid>https://orcid.org/0000-0001-7300-2355</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Bicarbonates - metabolism Brain - diagnostic imaging Brain - metabolism Carbon Isotopes - metabolism Humans Lactic Acid - metabolism Magnetic Resonance Imaging - methods Pyruvic Acid - metabolism |
| title | Age-associated change in pyruvate metabolism investigated with hyperpolarized 13 C-MRI of the human brain |
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