Design, synthesis and evaluation of 2-aryl quinoline derivatives against 12R-lipoxygenase (12R-LOX): Discovery of first inhibitor of 12R-LOX

The synthesis, in silico and in vitro evaluation of 2-aryl quinoline derivatives afforded the first example of 12R-hLOX inhibitors that reduced the hyper proliferative state and colony forming potential and decreased the protein levels of Ki67 and mRNA expression of IL-17A in the IMQ-induced psoriat...

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Veröffentlicht in:	Bioorganic chemistry 2023-09, Vol.138, p.106606-106606, Article 106606
Hauptverfasser:	Bhuktar, Harshavardhan, Shukla, Sharda, Kakularam, Kumar Reddy, Battu, Srikanth, Srikanth, Manupati, Srivastava, Susmita, Medishetti, Raghavender, Ram, Pooja, Jagadish, P.C., Rasool, Mahaboobkhan, Chakraborty, Sandipan, Khan, Nooruddin, Reddanna, Pallu, Oruganti, Srinivas, Pal, Manojit
Format:	Artikel
Sprache:	eng
Schlagworte:	12R-lipoxygenase Animals Arachidonate 12-Lipoxygenase - metabolism Humans Lipoxygenase Inhibitors - pharmacology Molecular Docking Simulation Psoriasis Quinoline Quinolines - pharmacology Skin - metabolism Structure-Activity Relationship Synthesis Zebrafish - metabolism
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