Distribution of cervical intraepithelial neoplasia is closely associated with HPV status and uterine position
Although cervical intraepithelial neoplasia (CIN) lesions are considered to be not randomly distributed across the cervix, but predominantly in the anterior wall, the clinicopathological etiology remains unknown. Herein, we aimed to elucidate the relationship between quantitatively measured area of...
Gespeichert in:
| Veröffentlicht in: | Journal of medical virology 2023-05, Vol.95 (5), p.e28777-n/a |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 5 |
| container_start_page | e28777 |
| container_title | Journal of medical virology |
| container_volume | 95 |
| creator | Tamura, Daisuke Sako, Wataru Watanabe, Rina Shitara, Akihiro Saito, Fumiko Yamauchi, Misa Sugita, Akihiro Karube, Akihiro |
| description | Although cervical intraepithelial neoplasia (CIN) lesions are considered to be not randomly distributed across the cervix, but predominantly in the anterior wall, the clinicopathological etiology remains unknown. Herein, we aimed to elucidate the relationship between quantitatively measured area of CIN2/3 and cervical cancer associated factors by retrospective cohort study. We analyzed 235 consecutive therapeutic conization specimens dissected as a single intact section to determine CIN2/3 area and its correlation with both clinical risk factors including human papillomavirus (HPV) status (single or multiple infection) and uterine position defined by transvaginal ultrasound. Cervical wall was classified into three groups: anterior: (11, 12, 1, and 2 o'clock), posterior (5, 6, 7, and 8 o'clock) and lateral (3, 4, 9, and 10 o'clock). Multiple regression revealed that younger age and HPV16 status were significantly correlated with CIN2/3 area (p = 0.0224 and p = 0.0075, respectively). The Jonckheere‐Terpstra test showed a significant trend: CIN2/3 area was highest in the single HPV16 group, followed by the multiple HPV16 group and the non‐HPV16 group (p |
| doi_str_mv | 10.1002/jmv.28777 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2817777131</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2817777131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3137-6b7961f6286c19fccba2979ced06a19ca9b4151b4f13bf2162f96c840ab4b0f03</originalsourceid><addsrcrecordid>eNp10UFvFCEUB3BiNHZdPfgFDIkXPUzLY2ZhOJraWk2betBeJ8BCZMMMI49ps99e1q0eTDwRkl_-D96fkNfAToExfrYb7095L6V8QlbAlGgUk_CUrBh0ohECNifkBeKOMdYrzp-Tk1Zy4C1jKzJ-DFhyMEsJaaLJU-vyfbA60jCVrN0cyg8XQ71PLs1RY9A0ILUxoYt7qhGTDbq4LX2okl59vaNYdFmQ6mlLl-JymBydE4bDgJfkmdcR3avHc02-X158O79qrm8_fT7_cN3YFlrZCCOVAC94Lywob63RXEll3ZYJDcpqZTrYgOk8tMZzENwrYfuOadMZ5lm7Ju-OuXNOPxeHZRgDWhejrr9YcOA91G1JqNPW5O0_dJeWPNXXHZTadJ3Y9FW9PyqbE2J2fphzGHXeD8CGQwdD7WD43UG1bx4TFzO67V_5Z-kVnB3BQ4hu__-k4cvN3THyF9cakc4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2819544658</pqid></control><display><type>article</type><title>Distribution of cervical intraepithelial neoplasia is closely associated with HPV status and uterine position</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Tamura, Daisuke ; Sako, Wataru ; Watanabe, Rina ; Shitara, Akihiro ; Saito, Fumiko ; Yamauchi, Misa ; Sugita, Akihiro ; Karube, Akihiro</creator><creatorcontrib>Tamura, Daisuke ; Sako, Wataru ; Watanabe, Rina ; Shitara, Akihiro ; Saito, Fumiko ; Yamauchi, Misa ; Sugita, Akihiro ; Karube, Akihiro</creatorcontrib><description>Although cervical intraepithelial neoplasia (CIN) lesions are considered to be not randomly distributed across the cervix, but predominantly in the anterior wall, the clinicopathological etiology remains unknown. Herein, we aimed to elucidate the relationship between quantitatively measured area of CIN2/3 and cervical cancer associated factors by retrospective cohort study. We analyzed 235 consecutive therapeutic conization specimens dissected as a single intact section to determine CIN2/3 area and its correlation with both clinical risk factors including human papillomavirus (HPV) status (single or multiple infection) and uterine position defined by transvaginal ultrasound. Cervical wall was classified into three groups: anterior: (11, 12, 1, and 2 o'clock), posterior (5, 6, 7, and 8 o'clock) and lateral (3, 4, 9, and 10 o'clock). Multiple regression revealed that younger age and HPV16 status were significantly correlated with CIN2/3 area (p = 0.0224 and p = 0.0075, respectively). The Jonckheere‐Terpstra test showed a significant trend: CIN2/3 area was highest in the single HPV16 group, followed by the multiple HPV16 group and the non‐HPV16 group (p < 0.0001). CIN2/3 area in the anterior wall was statistically significantly larger than the posterior and lateral wall (p = 0.0059 and p = 0.0107, respectively). CIN2/3 area in the anterior wall was significantly greater with anteversion‐anteflexion than retroversion‐retroflexion (p = 0.0485), whereas CIN2/3 area in the posterior wall was significantly larger with retroversion‐retroflexion than anteversion‐anteflexion (p = 0.0394). In conclusion, the topographical distribution of CIN2/3 area is closely associated with patient age, high‐risk HPV status, especially single HPV16 infection and uterine position.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.28777</identifier><identifier>PMID: 37212300</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Cervical cancer ; cervical intraepithelial neoplasia ; Cervix ; Cervix Uteri ; conization ; Female ; HPV16 ; Human papillomavirus ; Human papillomavirus 16 ; Human Papillomavirus Viruses ; Humans ; multiple HPV infection ; Papillomaviridae - genetics ; Papillomavirus Infections ; Retrospective Studies ; Risk factors ; Uterine Cervical Dysplasia ; Uterine Cervical Neoplasms ; uterine position ; Uterus ; Virology</subject><ispartof>Journal of medical virology, 2023-05, Vol.95 (5), p.e28777-n/a</ispartof><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3137-6b7961f6286c19fccba2979ced06a19ca9b4151b4f13bf2162f96c840ab4b0f03</cites><orcidid>0000-0001-9808-1897</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.28777$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.28777$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37212300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tamura, Daisuke</creatorcontrib><creatorcontrib>Sako, Wataru</creatorcontrib><creatorcontrib>Watanabe, Rina</creatorcontrib><creatorcontrib>Shitara, Akihiro</creatorcontrib><creatorcontrib>Saito, Fumiko</creatorcontrib><creatorcontrib>Yamauchi, Misa</creatorcontrib><creatorcontrib>Sugita, Akihiro</creatorcontrib><creatorcontrib>Karube, Akihiro</creatorcontrib><title>Distribution of cervical intraepithelial neoplasia is closely associated with HPV status and uterine position</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>Although cervical intraepithelial neoplasia (CIN) lesions are considered to be not randomly distributed across the cervix, but predominantly in the anterior wall, the clinicopathological etiology remains unknown. Herein, we aimed to elucidate the relationship between quantitatively measured area of CIN2/3 and cervical cancer associated factors by retrospective cohort study. We analyzed 235 consecutive therapeutic conization specimens dissected as a single intact section to determine CIN2/3 area and its correlation with both clinical risk factors including human papillomavirus (HPV) status (single or multiple infection) and uterine position defined by transvaginal ultrasound. Cervical wall was classified into three groups: anterior: (11, 12, 1, and 2 o'clock), posterior (5, 6, 7, and 8 o'clock) and lateral (3, 4, 9, and 10 o'clock). Multiple regression revealed that younger age and HPV16 status were significantly correlated with CIN2/3 area (p = 0.0224 and p = 0.0075, respectively). The Jonckheere‐Terpstra test showed a significant trend: CIN2/3 area was highest in the single HPV16 group, followed by the multiple HPV16 group and the non‐HPV16 group (p < 0.0001). CIN2/3 area in the anterior wall was statistically significantly larger than the posterior and lateral wall (p = 0.0059 and p = 0.0107, respectively). CIN2/3 area in the anterior wall was significantly greater with anteversion‐anteflexion than retroversion‐retroflexion (p = 0.0485), whereas CIN2/3 area in the posterior wall was significantly larger with retroversion‐retroflexion than anteversion‐anteflexion (p = 0.0394). In conclusion, the topographical distribution of CIN2/3 area is closely associated with patient age, high‐risk HPV status, especially single HPV16 infection and uterine position.</description><subject>Cervical cancer</subject><subject>cervical intraepithelial neoplasia</subject><subject>Cervix</subject><subject>Cervix Uteri</subject><subject>conization</subject><subject>Female</subject><subject>HPV16</subject><subject>Human papillomavirus</subject><subject>Human papillomavirus 16</subject><subject>Human Papillomavirus Viruses</subject><subject>Humans</subject><subject>multiple HPV infection</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomavirus Infections</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Uterine Cervical Dysplasia</subject><subject>Uterine Cervical Neoplasms</subject><subject>uterine position</subject><subject>Uterus</subject><subject>Virology</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10UFvFCEUB3BiNHZdPfgFDIkXPUzLY2ZhOJraWk2betBeJ8BCZMMMI49ps99e1q0eTDwRkl_-D96fkNfAToExfrYb7095L6V8QlbAlGgUk_CUrBh0ohECNifkBeKOMdYrzp-Tk1Zy4C1jKzJ-DFhyMEsJaaLJU-vyfbA60jCVrN0cyg8XQ71PLs1RY9A0ILUxoYt7qhGTDbq4LX2okl59vaNYdFmQ6mlLl-JymBydE4bDgJfkmdcR3avHc02-X158O79qrm8_fT7_cN3YFlrZCCOVAC94Lywob63RXEll3ZYJDcpqZTrYgOk8tMZzENwrYfuOadMZ5lm7Ju-OuXNOPxeHZRgDWhejrr9YcOA91G1JqNPW5O0_dJeWPNXXHZTadJ3Y9FW9PyqbE2J2fphzGHXeD8CGQwdD7WD43UG1bx4TFzO67V_5Z-kVnB3BQ4hu__-k4cvN3THyF9cakc4</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Tamura, Daisuke</creator><creator>Sako, Wataru</creator><creator>Watanabe, Rina</creator><creator>Shitara, Akihiro</creator><creator>Saito, Fumiko</creator><creator>Yamauchi, Misa</creator><creator>Sugita, Akihiro</creator><creator>Karube, Akihiro</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9808-1897</orcidid></search><sort><creationdate>202305</creationdate><title>Distribution of cervical intraepithelial neoplasia is closely associated with HPV status and uterine position</title><author>Tamura, Daisuke ; Sako, Wataru ; Watanabe, Rina ; Shitara, Akihiro ; Saito, Fumiko ; Yamauchi, Misa ; Sugita, Akihiro ; Karube, Akihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3137-6b7961f6286c19fccba2979ced06a19ca9b4151b4f13bf2162f96c840ab4b0f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cervical cancer</topic><topic>cervical intraepithelial neoplasia</topic><topic>Cervix</topic><topic>Cervix Uteri</topic><topic>conization</topic><topic>Female</topic><topic>HPV16</topic><topic>Human papillomavirus</topic><topic>Human papillomavirus 16</topic><topic>Human Papillomavirus Viruses</topic><topic>Humans</topic><topic>multiple HPV infection</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomavirus Infections</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Uterine Cervical Dysplasia</topic><topic>Uterine Cervical Neoplasms</topic><topic>uterine position</topic><topic>Uterus</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tamura, Daisuke</creatorcontrib><creatorcontrib>Sako, Wataru</creatorcontrib><creatorcontrib>Watanabe, Rina</creatorcontrib><creatorcontrib>Shitara, Akihiro</creatorcontrib><creatorcontrib>Saito, Fumiko</creatorcontrib><creatorcontrib>Yamauchi, Misa</creatorcontrib><creatorcontrib>Sugita, Akihiro</creatorcontrib><creatorcontrib>Karube, Akihiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamura, Daisuke</au><au>Sako, Wataru</au><au>Watanabe, Rina</au><au>Shitara, Akihiro</au><au>Saito, Fumiko</au><au>Yamauchi, Misa</au><au>Sugita, Akihiro</au><au>Karube, Akihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of cervical intraepithelial neoplasia is closely associated with HPV status and uterine position</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J Med Virol</addtitle><date>2023-05</date><risdate>2023</risdate><volume>95</volume><issue>5</issue><spage>e28777</spage><epage>n/a</epage><pages>e28777-n/a</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>Although cervical intraepithelial neoplasia (CIN) lesions are considered to be not randomly distributed across the cervix, but predominantly in the anterior wall, the clinicopathological etiology remains unknown. Herein, we aimed to elucidate the relationship between quantitatively measured area of CIN2/3 and cervical cancer associated factors by retrospective cohort study. We analyzed 235 consecutive therapeutic conization specimens dissected as a single intact section to determine CIN2/3 area and its correlation with both clinical risk factors including human papillomavirus (HPV) status (single or multiple infection) and uterine position defined by transvaginal ultrasound. Cervical wall was classified into three groups: anterior: (11, 12, 1, and 2 o'clock), posterior (5, 6, 7, and 8 o'clock) and lateral (3, 4, 9, and 10 o'clock). Multiple regression revealed that younger age and HPV16 status were significantly correlated with CIN2/3 area (p = 0.0224 and p = 0.0075, respectively). The Jonckheere‐Terpstra test showed a significant trend: CIN2/3 area was highest in the single HPV16 group, followed by the multiple HPV16 group and the non‐HPV16 group (p < 0.0001). CIN2/3 area in the anterior wall was statistically significantly larger than the posterior and lateral wall (p = 0.0059 and p = 0.0107, respectively). CIN2/3 area in the anterior wall was significantly greater with anteversion‐anteflexion than retroversion‐retroflexion (p = 0.0485), whereas CIN2/3 area in the posterior wall was significantly larger with retroversion‐retroflexion than anteversion‐anteflexion (p = 0.0394). In conclusion, the topographical distribution of CIN2/3 area is closely associated with patient age, high‐risk HPV status, especially single HPV16 infection and uterine position.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37212300</pmid><doi>10.1002/jmv.28777</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9808-1897</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-6615 |
| ispartof | Journal of medical virology, 2023-05, Vol.95 (5), p.e28777-n/a |
| issn | 0146-6615 1096-9071 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2817777131 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Cervical cancer cervical intraepithelial neoplasia Cervix Cervix Uteri conization Female HPV16 Human papillomavirus Human papillomavirus 16 Human Papillomavirus Viruses Humans multiple HPV infection Papillomaviridae - genetics Papillomavirus Infections Retrospective Studies Risk factors Uterine Cervical Dysplasia Uterine Cervical Neoplasms uterine position Uterus Virology |
| title | Distribution of cervical intraepithelial neoplasia is closely associated with HPV status and uterine position |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T10%3A53%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Distribution%20of%20cervical%20intraepithelial%20neoplasia%20is%20closely%20associated%20with%20HPV%20status%20and%20uterine%20position&rft.jtitle=Journal%20of%20medical%20virology&rft.au=Tamura,%20Daisuke&rft.date=2023-05&rft.volume=95&rft.issue=5&rft.spage=e28777&rft.epage=n/a&rft.pages=e28777-n/a&rft.issn=0146-6615&rft.eissn=1096-9071&rft_id=info:doi/10.1002/jmv.28777&rft_dat=%3Cproquest_cross%3E2817777131%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2819544658&rft_id=info:pmid/37212300&rfr_iscdi=true |