Nicotinamide N-methyl transferase and cancer-associated thrombosis: insights to prevention and management

Nicotinamide metabolism is important in carcinogenesis. Nicotinamide affects the cellular methyl pool, thus affecting DNA and histone methylation and gene expression. Cancer cells have increased expression of nicotinamide N-methyl transferase (NNMT), the key enzyme in nicotinamide metabolism. NNMT c...

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Veröffentlicht in:	Epigenomics 2023-03, Vol.15 (6), p.385-395
Hauptverfasser:	Jabbari, Parnian, Ardakany, Marzieh Roayaei, Ebrahimi, Saied, Rezaei, Nima
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology cancer metabolomics cancer-associated thrombosis Carcinogenesis homocysteine Humans Neoplasms - complications Neoplasms - drug therapy Neoplasms - genetics Niacinamide - pharmacology Niacinamide - therapeutic use nicotinamide nicotinamide N-methyl transferase Nicotinamide N-Methyltransferase - genetics Nicotinamide N-Methyltransferase - metabolism Transferases
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