Baicalin inhibits influenza A (H1N1)‐induced pyroptosis of lung alveolar epithelial cells via caspase‐3/GSDME pathway

Baicalin (7‐d‐glucuronic acid‐5, 6‐dihydroxyflavone) derived from the root of Scutellaria baicalensis used as Traditional Chinese Medicine (TCM) has been revealed to exert potential antiviral activity via various pathways, while the molecular mechanisms have not been fully understood. Pyroptosis, an...

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Veröffentlicht in:	Journal of medical virology 2023-05, Vol.95 (5), p.e28790-n/a
Hauptverfasser:	Wei, Zhenqiao, Gao, Rui, Sun, Zhen, Yang, Wen, He, Qi, Wang, Chenhui, Zhang, Jingxiang, Zhang, Xiaochang, Guo, Liang, Wang, Shengqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar Epithelial Cells - metabolism Alveoli Animal tissues Animals Antiviral activity Antiviral Agents - pharmacology Apoptosis Baicalin Caspase Caspase 3 - genetics Caspase 3 - metabolism caspase‐3 Cell death Cell fate Cell lines Epithelial cells Epithelium GSDME H1N1 Herbal medicine Humans Inflammation Influenza A Influenza A Virus, H1N1 Subtype Influenza, Human - drug therapy Iodides L-Lactate dehydrogenase Lactate dehydrogenase Lung - metabolism Lungs Mice Molecular modelling Propidium iodide Pyroptosis siRNA Traditional Chinese medicine Transcriptomes Virology
Online-Zugang:	Volltext
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