A pipeline for testing drug mechanism of action and combination therapies: From microarray data to simulations via Linear-In-Flux-Expressions: Testing four-drug combinations for tuberculosis treatment

Computational methods are becoming commonly used in many areas of medical research. Recently, the modeling of biological mechanisms associated with disease pathophysiology have benefited from approaches such as Quantitative Systems Pharmacology (briefly QSP) and Physiologically Based Pharmacokinetic...

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Veröffentlicht in:	Mathematical biosciences 2023-06, Vol.360, p.108983-108983
Hauptverfasser:	Denaro, Christopher, Merrill, Nathaniel J, McQuade, Sean T, Reed, Logan, Azer, Karim, Piccoli, Benedetto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Microarray Analysis Models, Biological Tuberculosis - drug therapy
Online-Zugang:	Volltext
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