Triazine herbicides exposure, natural immunoglobulin M antibodies, and fasting plasma glucose changes: Association and mediation analyses in general Chinese urban adults
The effects of triazine herbicides on glucose metabolism remain unclear. In this study, we aimed to assess the associations between serum triazine herbicides and glycemia-related risk indicators in general adults, and to evaluate the mediating role of natural immunoglobulin M antibodies (IgM) in the...
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| Veröffentlicht in: | Environmental pollution (1987) 2023-08, Vol.330, p.121833-121833, Article 121833 |
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| container_title | Environmental pollution (1987) |
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| creator | Wang, Mengyi Zhou, Min Tan, Qiyou Yu, Linling Dong, Chaoqian Liang, Ruyi Liu, Wei Zhang, Yongfang Li, Minjing Nie, XiuQuan Jing, Tao Chen, Weihong |
| description | The effects of triazine herbicides on glucose metabolism remain unclear. In this study, we aimed to assess the associations between serum triazine herbicides and glycemia-related risk indicators in general adults, and to evaluate the mediating role of natural immunoglobulin M antibodies (IgM) in the above associations among uninfected participants. We measured the concentrations of atrazine, cyanazine, and IgM in serum, as well as fasting plasma glucose (FPG), and fasting plasma insulin in 4423 adult participants from the Wuhan-Zhuhai cohort baseline population, enrolled in 2011–2012. Generalized linear models were used to evaluate the associations of serum triazine herbicides with glycemia-related risk indicators, and mediation analyses were performed to evaluate the mediating role of serum IgM in the above associations. The median levels of serum atrazine and cyanazine were 0.0237 μg/L and 0.0786 μg/L, respectively. Our study found significant positive associations of serum atrazine, cyanazine, and Σtriazine with FPG levels, risk of impaired fasting glucose (IFG), abnormal glucose regulation (AGR), and type 2 diabetes (T2D). Additionally, serum cyanazine and Σtriazine were found to be significant positive associated with the homeostatic model assessment of insulin resistance (HOMA-IR) levels. Significant negative linear relationships were observed in associations of serum IgM with serum triazine herbicides, FPG, HOMA-IR levels, the prevalence of T2D, and AGR (P |
| doi_str_mv | 10.1016/j.envpol.2023.121833 |
| format | Article |
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[Display omitted]
•Serum samples were measured for atrazine and cyanazine among general urban adults.•Triazine herbicide exposure was associated with abnormal glucose metabolism.•Triazine herbicide exposure was negatively associated with serum IgM level.•Down-regulated serum IgM level was associated with abnormal glucose metabolism.•IgM mediated triazine herbicide exposure-associated abnormal glucose metabolism.</description><identifier>ISSN: 0269-7491</identifier><identifier>EISSN: 1873-6424</identifier><identifier>DOI: 10.1016/j.envpol.2023.121833</identifier><identifier>PMID: 37201570</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Atrazine ; Blood Glucose - metabolism ; Cyanazine ; Diabetes Mellitus, Type 2 ; East Asian People ; Fasting ; Glucose ; Glucose homeostasis ; Herbicides ; Humans ; Immunoglobulin ; Insulin Resistance - physiology ; Mediation Analysis ; Triazines</subject><ispartof>Environmental pollution (1987), 2023-08, Vol.330, p.121833-121833, Article 121833</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-f358f722feba2e0b2234dc0ce448a1355fa701dacea05ef9452c240f5de6fa723</citedby><cites>FETCH-LOGICAL-c362t-f358f722feba2e0b2234dc0ce448a1355fa701dacea05ef9452c240f5de6fa723</cites><orcidid>0000-0001-8689-7311</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0269749123008357$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37201570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Mengyi</creatorcontrib><creatorcontrib>Zhou, Min</creatorcontrib><creatorcontrib>Tan, Qiyou</creatorcontrib><creatorcontrib>Yu, Linling</creatorcontrib><creatorcontrib>Dong, Chaoqian</creatorcontrib><creatorcontrib>Liang, Ruyi</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Zhang, Yongfang</creatorcontrib><creatorcontrib>Li, Minjing</creatorcontrib><creatorcontrib>Nie, XiuQuan</creatorcontrib><creatorcontrib>Jing, Tao</creatorcontrib><creatorcontrib>Chen, Weihong</creatorcontrib><title>Triazine herbicides exposure, natural immunoglobulin M antibodies, and fasting plasma glucose changes: Association and mediation analyses in general Chinese urban adults</title><title>Environmental pollution (1987)</title><addtitle>Environ Pollut</addtitle><description>The effects of triazine herbicides on glucose metabolism remain unclear. In this study, we aimed to assess the associations between serum triazine herbicides and glycemia-related risk indicators in general adults, and to evaluate the mediating role of natural immunoglobulin M antibodies (IgM) in the above associations among uninfected participants. We measured the concentrations of atrazine, cyanazine, and IgM in serum, as well as fasting plasma glucose (FPG), and fasting plasma insulin in 4423 adult participants from the Wuhan-Zhuhai cohort baseline population, enrolled in 2011–2012. Generalized linear models were used to evaluate the associations of serum triazine herbicides with glycemia-related risk indicators, and mediation analyses were performed to evaluate the mediating role of serum IgM in the above associations. The median levels of serum atrazine and cyanazine were 0.0237 μg/L and 0.0786 μg/L, respectively. Our study found significant positive associations of serum atrazine, cyanazine, and Σtriazine with FPG levels, risk of impaired fasting glucose (IFG), abnormal glucose regulation (AGR), and type 2 diabetes (T2D). Additionally, serum cyanazine and Σtriazine were found to be significant positive associated with the homeostatic model assessment of insulin resistance (HOMA-IR) levels. Significant negative linear relationships were observed in associations of serum IgM with serum triazine herbicides, FPG, HOMA-IR levels, the prevalence of T2D, and AGR (P < 0.05). Furthermore, we observed a significant mediating role by IgM in the associations of serum triazine herbicides with FPG, HOMA-IR, and AGR, with the proportions ranging from 2.96% to 7.71%. To ensure the stability of our findings, we conducted sensitivity analyses in normoglycemic participants and found that the association of serum IgM with FPG and the mediating role by IgM remained stable. Our results suggest that triazine herbicides exposure is positively associated with abnormal glucose metabolism, and decreasing serum IgM may partly mediate these associations.
[Display omitted]
•Serum samples were measured for atrazine and cyanazine among general urban adults.•Triazine herbicide exposure was associated with abnormal glucose metabolism.•Triazine herbicide exposure was negatively associated with serum IgM level.•Down-regulated serum IgM level was associated with abnormal glucose metabolism.•IgM mediated triazine herbicide exposure-associated abnormal glucose metabolism.</description><subject>Adult</subject><subject>Atrazine</subject><subject>Blood Glucose - metabolism</subject><subject>Cyanazine</subject><subject>Diabetes Mellitus, Type 2</subject><subject>East Asian People</subject><subject>Fasting</subject><subject>Glucose</subject><subject>Glucose homeostasis</subject><subject>Herbicides</subject><subject>Humans</subject><subject>Immunoglobulin</subject><subject>Insulin Resistance - physiology</subject><subject>Mediation Analysis</subject><subject>Triazines</subject><issn>0269-7491</issn><issn>1873-6424</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EokPhDRDykkUz-C8_wwKpGkGLVMSmrC3Hucl45NjBN6la3oi3xENKl6x8LX_nHt97CHnL2ZYzXn04biHcTdFvBRNyywVvpHxGNrypZVEpoZ6TDRPVrqjVjp-RV4hHxpiSUr4kZ7IWjJc125Dft8mZXy4APUBqnXUdIIX7KeKS4IIGMy_JeOrGcQlx8LFdvAv0GzVhdm3sHOBFrjvaG5xdGOjkDY6GDn6xEYHagwkD4Ed6iRitM7OL4S8_Qvd0M_4Bs2vuO0CAk93-kH-U5UtqTSa6xc_4mrzojUd483iekx9fPt_ur4ub71df95c3hZWVmItelk1fC9FDawSwVgipOsssKNUYLsuyNzXjnbFgWAn9TpXCCsX6soMqPwl5Tt6vfacUfy6Asx4dWvDeBIgLatHwqi53u-aEqhW1KSIm6PWU3GjSg-ZMn0LSR72GpE8h6TWkLHv36LC0eQ9Pon-pZODTCkCe885B0mgdBJt3lsDOuovu_w5_ANTjqbI</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Wang, Mengyi</creator><creator>Zhou, Min</creator><creator>Tan, Qiyou</creator><creator>Yu, Linling</creator><creator>Dong, Chaoqian</creator><creator>Liang, Ruyi</creator><creator>Liu, Wei</creator><creator>Zhang, Yongfang</creator><creator>Li, Minjing</creator><creator>Nie, XiuQuan</creator><creator>Jing, Tao</creator><creator>Chen, Weihong</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8689-7311</orcidid></search><sort><creationdate>20230801</creationdate><title>Triazine herbicides exposure, natural immunoglobulin M antibodies, and fasting plasma glucose changes: Association and mediation analyses in general Chinese urban adults</title><author>Wang, Mengyi ; Zhou, Min ; Tan, Qiyou ; Yu, Linling ; Dong, Chaoqian ; Liang, Ruyi ; Liu, Wei ; Zhang, Yongfang ; Li, Minjing ; Nie, XiuQuan ; Jing, Tao ; Chen, Weihong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-f358f722feba2e0b2234dc0ce448a1355fa701dacea05ef9452c240f5de6fa723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Atrazine</topic><topic>Blood Glucose - metabolism</topic><topic>Cyanazine</topic><topic>Diabetes Mellitus, Type 2</topic><topic>East Asian People</topic><topic>Fasting</topic><topic>Glucose</topic><topic>Glucose homeostasis</topic><topic>Herbicides</topic><topic>Humans</topic><topic>Immunoglobulin</topic><topic>Insulin Resistance - physiology</topic><topic>Mediation Analysis</topic><topic>Triazines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Mengyi</creatorcontrib><creatorcontrib>Zhou, Min</creatorcontrib><creatorcontrib>Tan, Qiyou</creatorcontrib><creatorcontrib>Yu, Linling</creatorcontrib><creatorcontrib>Dong, Chaoqian</creatorcontrib><creatorcontrib>Liang, Ruyi</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Zhang, Yongfang</creatorcontrib><creatorcontrib>Li, Minjing</creatorcontrib><creatorcontrib>Nie, XiuQuan</creatorcontrib><creatorcontrib>Jing, Tao</creatorcontrib><creatorcontrib>Chen, Weihong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental pollution (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Mengyi</au><au>Zhou, Min</au><au>Tan, Qiyou</au><au>Yu, Linling</au><au>Dong, Chaoqian</au><au>Liang, Ruyi</au><au>Liu, Wei</au><au>Zhang, Yongfang</au><au>Li, Minjing</au><au>Nie, XiuQuan</au><au>Jing, Tao</au><au>Chen, Weihong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Triazine herbicides exposure, natural immunoglobulin M antibodies, and fasting plasma glucose changes: Association and mediation analyses in general Chinese urban adults</atitle><jtitle>Environmental pollution (1987)</jtitle><addtitle>Environ Pollut</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>330</volume><spage>121833</spage><epage>121833</epage><pages>121833-121833</pages><artnum>121833</artnum><issn>0269-7491</issn><eissn>1873-6424</eissn><abstract>The effects of triazine herbicides on glucose metabolism remain unclear. In this study, we aimed to assess the associations between serum triazine herbicides and glycemia-related risk indicators in general adults, and to evaluate the mediating role of natural immunoglobulin M antibodies (IgM) in the above associations among uninfected participants. We measured the concentrations of atrazine, cyanazine, and IgM in serum, as well as fasting plasma glucose (FPG), and fasting plasma insulin in 4423 adult participants from the Wuhan-Zhuhai cohort baseline population, enrolled in 2011–2012. Generalized linear models were used to evaluate the associations of serum triazine herbicides with glycemia-related risk indicators, and mediation analyses were performed to evaluate the mediating role of serum IgM in the above associations. The median levels of serum atrazine and cyanazine were 0.0237 μg/L and 0.0786 μg/L, respectively. Our study found significant positive associations of serum atrazine, cyanazine, and Σtriazine with FPG levels, risk of impaired fasting glucose (IFG), abnormal glucose regulation (AGR), and type 2 diabetes (T2D). Additionally, serum cyanazine and Σtriazine were found to be significant positive associated with the homeostatic model assessment of insulin resistance (HOMA-IR) levels. Significant negative linear relationships were observed in associations of serum IgM with serum triazine herbicides, FPG, HOMA-IR levels, the prevalence of T2D, and AGR (P < 0.05). Furthermore, we observed a significant mediating role by IgM in the associations of serum triazine herbicides with FPG, HOMA-IR, and AGR, with the proportions ranging from 2.96% to 7.71%. To ensure the stability of our findings, we conducted sensitivity analyses in normoglycemic participants and found that the association of serum IgM with FPG and the mediating role by IgM remained stable. Our results suggest that triazine herbicides exposure is positively associated with abnormal glucose metabolism, and decreasing serum IgM may partly mediate these associations.
[Display omitted]
•Serum samples were measured for atrazine and cyanazine among general urban adults.•Triazine herbicide exposure was associated with abnormal glucose metabolism.•Triazine herbicide exposure was negatively associated with serum IgM level.•Down-regulated serum IgM level was associated with abnormal glucose metabolism.•IgM mediated triazine herbicide exposure-associated abnormal glucose metabolism.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37201570</pmid><doi>10.1016/j.envpol.2023.121833</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-8689-7311</orcidid></addata></record> |
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| ispartof | Environmental pollution (1987), 2023-08, Vol.330, p.121833-121833, Article 121833 |
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| subjects | Adult Atrazine Blood Glucose - metabolism Cyanazine Diabetes Mellitus, Type 2 East Asian People Fasting Glucose Glucose homeostasis Herbicides Humans Immunoglobulin Insulin Resistance - physiology Mediation Analysis Triazines |
| title | Triazine herbicides exposure, natural immunoglobulin M antibodies, and fasting plasma glucose changes: Association and mediation analyses in general Chinese urban adults |
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