Guiqi Baizhu prescription ameliorates cytarabine-induced intestinal mucositis by targeting JAK2 to inhibit M1 macrophage polarization

Intestinal mucositis (IM) is characterized by damage to the intestinal mucosa resulting from inhibition of epithelial cell division and loss of renewal capacity following anticancer chemotherapy and radiotherapy. Cytarabine (Ara-C), the main chemotherapy drug for the treatment of leukemia and lympho...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2023-08, Vol.164, p.114902-114902, Article 114902
Hauptverfasser:	Chu, Wei, Li, Ya-ling, Li, Jun-jie, Lin, Jia, Li, Mi, Wang, Jiao, He, Jian-zheng, Zhang, Yue-mei, Yao, Juan, Jin, Xiao-jie, Cai, Hui, Liu, Yong-qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridine Animals Cytarabine - pharmacology Interferon-gamma - metabolism Intestinal mucositis JAK2/STAT1 Lipopolysaccharides - metabolism Lipopolysaccharides - pharmacology Macrophage polarization Macrophages - metabolism Mice Molecular Docking Simulation Mucositis - pathology Senkyunolide A
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