Incidence and risk factors for complex regional pain syndrome in radius fractures: meta-analysis
Purpose This meta-analysis aimed to evaluate the incidence and risk factors for complex regional pain syndrome (CRPS) in radius fractures. Methods The meta-analysis was performed using the PubMed, Embase, Scopus, and Cochrane Collaboration Library databases. Studies focusing on patients with conserv...
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| Veröffentlicht in: | Archives of orthopaedic and trauma surgery 2023-09, Vol.143 (9), p.5687-5699 |
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| creator | Lorente, Alejandro Mariscal, Gonzalo Lorente, Rafael |
| description | Purpose
This meta-analysis aimed to evaluate the incidence and risk factors for complex regional pain syndrome (CRPS) in radius fractures.
Methods
The meta-analysis was performed using the PubMed, Embase, Scopus, and Cochrane Collaboration Library databases. Studies focusing on patients with conservative or surgically treated radius fractures leading to CRPS were included. A control group consisting of patients with radius fractures and no CRPS (−) was included. The outcome measures were incidence and risk factors. Comparative studies were also included. Data were combined using Review Manager 5.4.
Results
Out of 610 studies, nine studies were included. The incidence of CRPS after radius fractures ranged from 0.19 to 13.63% (95% CI: 11.12–16.15%). Open fractures, high-energy mechanisms in radial head fractures, and associations with ulnar fractures were risk factors for CRPS [(RR: 0.98; 95% CI: 0.97–1.00), (RR: 0.18; 95% CI: 0.07–0.47), and (RR: 1.25; 95% CI: 1.17–1.35), respectively]. Other risk factors were female sex and high body mass index [(RR: 1.20; 95% CI: 1.05–1.37) and (MD: 1.17; 95% CI: 0.45–1.88)]. Psychiatric factors also increased the incidence of CRPS (RR: 2.04; 95% CI: 1.83–2.28). On the other hand, the type of surgery (external fixation or open reduction and internal fixation) and manipulations; associated comorbidities (diabetes and hypertension) together with tobacco and alcohol abuse; marital status, educational level, employment status, and socioeconomic status were not risk factors (
p
> 0.05).
Conclusion
The incidence of CRPS in radius fractures was 13.63%. Fractures with greater complexity or greater associated tissue damage, female sex, high BMI, and psychiatric disorders were risk factors for the development of CRPS.
Level of evidence
Meta-analysis of cohort and case series studies; II. |
| doi_str_mv | 10.1007/s00402-023-04909-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2816759157</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2856647983</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-e28b216de94051eed9c7190fb652065c3635ca4199ccdc30aa80f67a3d9d966b3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EglL4ARbIEhs2gbGdODE7hHhJldjA2rj2pEpJ4mI3Ev17XMpLLFh5JJ97Z3QIOWJwxgDK8wiQA8-AiwxyBSqrtsiI5SLPhGJy-9e8R_ZjnAMwXinYJXui5KC4YCPyfN_bxmFvkZre0dDEF1obu_Qh0toHan23aPGNBpw1vjctXZimp3HVu-A7pGkOxjVDgkNKDQHjBe1waTKT4FVs4gHZqU0b8fDzHZOnm-vHq7ts8nB7f3U5yawoi2WGvJpyJh2qHAqG6JQtmYJ6KgsOsrBCisKanCllrbMCjKmglqURTjkl5VSMyemmdxH864BxqbsmWmxb06MfouYVk2WhWFEm9OQPOvdDSPeuqULKvFSVSBTfUDb4GAPWehGazoSVZqDX_vXGv07-9Yd_XaXQ8Wf1MO3QfUe-hCdAbICYvvoZhp_d_9S-A9emkG4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2856647983</pqid></control><display><type>article</type><title>Incidence and risk factors for complex regional pain syndrome in radius fractures: meta-analysis</title><source>SpringerNature Journals</source><creator>Lorente, Alejandro ; Mariscal, Gonzalo ; Lorente, Rafael</creator><creatorcontrib>Lorente, Alejandro ; Mariscal, Gonzalo ; Lorente, Rafael</creatorcontrib><description>Purpose
This meta-analysis aimed to evaluate the incidence and risk factors for complex regional pain syndrome (CRPS) in radius fractures.
Methods
The meta-analysis was performed using the PubMed, Embase, Scopus, and Cochrane Collaboration Library databases. Studies focusing on patients with conservative or surgically treated radius fractures leading to CRPS were included. A control group consisting of patients with radius fractures and no CRPS (−) was included. The outcome measures were incidence and risk factors. Comparative studies were also included. Data were combined using Review Manager 5.4.
Results
Out of 610 studies, nine studies were included. The incidence of CRPS after radius fractures ranged from 0.19 to 13.63% (95% CI: 11.12–16.15%). Open fractures, high-energy mechanisms in radial head fractures, and associations with ulnar fractures were risk factors for CRPS [(RR: 0.98; 95% CI: 0.97–1.00), (RR: 0.18; 95% CI: 0.07–0.47), and (RR: 1.25; 95% CI: 1.17–1.35), respectively]. Other risk factors were female sex and high body mass index [(RR: 1.20; 95% CI: 1.05–1.37) and (MD: 1.17; 95% CI: 0.45–1.88)]. Psychiatric factors also increased the incidence of CRPS (RR: 2.04; 95% CI: 1.83–2.28). On the other hand, the type of surgery (external fixation or open reduction and internal fixation) and manipulations; associated comorbidities (diabetes and hypertension) together with tobacco and alcohol abuse; marital status, educational level, employment status, and socioeconomic status were not risk factors (
p
> 0.05).
Conclusion
The incidence of CRPS in radius fractures was 13.63%. Fractures with greater complexity or greater associated tissue damage, female sex, high BMI, and psychiatric disorders were risk factors for the development of CRPS.
Level of evidence
Meta-analysis of cohort and case series studies; II.</description><identifier>ISSN: 1434-3916</identifier><identifier>ISSN: 0936-8051</identifier><identifier>EISSN: 1434-3916</identifier><identifier>DOI: 10.1007/s00402-023-04909-8</identifier><identifier>PMID: 37209231</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Alcohol abuse ; Chronic pain ; Medicine ; Medicine & Public Health ; Meta-analysis ; Orthopedics ; Risk factors ; Trauma Surgery</subject><ispartof>Archives of orthopaedic and trauma surgery, 2023-09, Vol.143 (9), p.5687-5699</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-e28b216de94051eed9c7190fb652065c3635ca4199ccdc30aa80f67a3d9d966b3</citedby><cites>FETCH-LOGICAL-c375t-e28b216de94051eed9c7190fb652065c3635ca4199ccdc30aa80f67a3d9d966b3</cites><orcidid>0000-0002-5166-198X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00402-023-04909-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00402-023-04909-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37209231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lorente, Alejandro</creatorcontrib><creatorcontrib>Mariscal, Gonzalo</creatorcontrib><creatorcontrib>Lorente, Rafael</creatorcontrib><title>Incidence and risk factors for complex regional pain syndrome in radius fractures: meta-analysis</title><title>Archives of orthopaedic and trauma surgery</title><addtitle>Arch Orthop Trauma Surg</addtitle><addtitle>Arch Orthop Trauma Surg</addtitle><description>Purpose
This meta-analysis aimed to evaluate the incidence and risk factors for complex regional pain syndrome (CRPS) in radius fractures.
Methods
The meta-analysis was performed using the PubMed, Embase, Scopus, and Cochrane Collaboration Library databases. Studies focusing on patients with conservative or surgically treated radius fractures leading to CRPS were included. A control group consisting of patients with radius fractures and no CRPS (−) was included. The outcome measures were incidence and risk factors. Comparative studies were also included. Data were combined using Review Manager 5.4.
Results
Out of 610 studies, nine studies were included. The incidence of CRPS after radius fractures ranged from 0.19 to 13.63% (95% CI: 11.12–16.15%). Open fractures, high-energy mechanisms in radial head fractures, and associations with ulnar fractures were risk factors for CRPS [(RR: 0.98; 95% CI: 0.97–1.00), (RR: 0.18; 95% CI: 0.07–0.47), and (RR: 1.25; 95% CI: 1.17–1.35), respectively]. Other risk factors were female sex and high body mass index [(RR: 1.20; 95% CI: 1.05–1.37) and (MD: 1.17; 95% CI: 0.45–1.88)]. Psychiatric factors also increased the incidence of CRPS (RR: 2.04; 95% CI: 1.83–2.28). On the other hand, the type of surgery (external fixation or open reduction and internal fixation) and manipulations; associated comorbidities (diabetes and hypertension) together with tobacco and alcohol abuse; marital status, educational level, employment status, and socioeconomic status were not risk factors (
p
> 0.05).
Conclusion
The incidence of CRPS in radius fractures was 13.63%. Fractures with greater complexity or greater associated tissue damage, female sex, high BMI, and psychiatric disorders were risk factors for the development of CRPS.
Level of evidence
Meta-analysis of cohort and case series studies; II.</description><subject>Alcohol abuse</subject><subject>Chronic pain</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Orthopedics</subject><subject>Risk factors</subject><subject>Trauma Surgery</subject><issn>1434-3916</issn><issn>0936-8051</issn><issn>1434-3916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kMtOwzAQRS0EglL4ARbIEhs2gbGdODE7hHhJldjA2rj2pEpJ4mI3Ev17XMpLLFh5JJ97Z3QIOWJwxgDK8wiQA8-AiwxyBSqrtsiI5SLPhGJy-9e8R_ZjnAMwXinYJXui5KC4YCPyfN_bxmFvkZre0dDEF1obu_Qh0toHan23aPGNBpw1vjctXZimp3HVu-A7pGkOxjVDgkNKDQHjBe1waTKT4FVs4gHZqU0b8fDzHZOnm-vHq7ts8nB7f3U5yawoi2WGvJpyJh2qHAqG6JQtmYJ6KgsOsrBCisKanCllrbMCjKmglqURTjkl5VSMyemmdxH864BxqbsmWmxb06MfouYVk2WhWFEm9OQPOvdDSPeuqULKvFSVSBTfUDb4GAPWehGazoSVZqDX_vXGv07-9Yd_XaXQ8Wf1MO3QfUe-hCdAbICYvvoZhp_d_9S-A9emkG4</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Lorente, Alejandro</creator><creator>Mariscal, Gonzalo</creator><creator>Lorente, Rafael</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5166-198X</orcidid></search><sort><creationdate>20230901</creationdate><title>Incidence and risk factors for complex regional pain syndrome in radius fractures: meta-analysis</title><author>Lorente, Alejandro ; Mariscal, Gonzalo ; Lorente, Rafael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-e28b216de94051eed9c7190fb652065c3635ca4199ccdc30aa80f67a3d9d966b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alcohol abuse</topic><topic>Chronic pain</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Orthopedics</topic><topic>Risk factors</topic><topic>Trauma Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lorente, Alejandro</creatorcontrib><creatorcontrib>Mariscal, Gonzalo</creatorcontrib><creatorcontrib>Lorente, Rafael</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of orthopaedic and trauma surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lorente, Alejandro</au><au>Mariscal, Gonzalo</au><au>Lorente, Rafael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence and risk factors for complex regional pain syndrome in radius fractures: meta-analysis</atitle><jtitle>Archives of orthopaedic and trauma surgery</jtitle><stitle>Arch Orthop Trauma Surg</stitle><addtitle>Arch Orthop Trauma Surg</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>143</volume><issue>9</issue><spage>5687</spage><epage>5699</epage><pages>5687-5699</pages><issn>1434-3916</issn><issn>0936-8051</issn><eissn>1434-3916</eissn><abstract>Purpose
This meta-analysis aimed to evaluate the incidence and risk factors for complex regional pain syndrome (CRPS) in radius fractures.
Methods
The meta-analysis was performed using the PubMed, Embase, Scopus, and Cochrane Collaboration Library databases. Studies focusing on patients with conservative or surgically treated radius fractures leading to CRPS were included. A control group consisting of patients with radius fractures and no CRPS (−) was included. The outcome measures were incidence and risk factors. Comparative studies were also included. Data were combined using Review Manager 5.4.
Results
Out of 610 studies, nine studies were included. The incidence of CRPS after radius fractures ranged from 0.19 to 13.63% (95% CI: 11.12–16.15%). Open fractures, high-energy mechanisms in radial head fractures, and associations with ulnar fractures were risk factors for CRPS [(RR: 0.98; 95% CI: 0.97–1.00), (RR: 0.18; 95% CI: 0.07–0.47), and (RR: 1.25; 95% CI: 1.17–1.35), respectively]. Other risk factors were female sex and high body mass index [(RR: 1.20; 95% CI: 1.05–1.37) and (MD: 1.17; 95% CI: 0.45–1.88)]. Psychiatric factors also increased the incidence of CRPS (RR: 2.04; 95% CI: 1.83–2.28). On the other hand, the type of surgery (external fixation or open reduction and internal fixation) and manipulations; associated comorbidities (diabetes and hypertension) together with tobacco and alcohol abuse; marital status, educational level, employment status, and socioeconomic status were not risk factors (
p
> 0.05).
Conclusion
The incidence of CRPS in radius fractures was 13.63%. Fractures with greater complexity or greater associated tissue damage, female sex, high BMI, and psychiatric disorders were risk factors for the development of CRPS.
Level of evidence
Meta-analysis of cohort and case series studies; II.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37209231</pmid><doi>10.1007/s00402-023-04909-8</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-5166-198X</orcidid></addata></record> |
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| subjects | Alcohol abuse Chronic pain Medicine Medicine & Public Health Meta-analysis Orthopedics Risk factors Trauma Surgery |
| title | Incidence and risk factors for complex regional pain syndrome in radius fractures: meta-analysis |
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