ACTH/cAMP-Mediated Skin Pigmentation Caused by 5-Fluorouracil Administration
Anticancer drugs exhibit many side effects, including skin pigmentation, which often lowers patient QOL. However, the mechanism of pigmentation caused by anticancer drugs remains unknown. The purpose of this study was to elucidate the mechanism of anticancer drug-induced skin pigmentation using 5-fl...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2023/07/01, Vol.46(7), pp.955-963 |
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| creator | Fujito, Atsuo Hiramoto, Keiichi Imai, Masashi Tanaka, Shota Ooi, Kazuya |
| description | Anticancer drugs exhibit many side effects, including skin pigmentation, which often lowers patient QOL. However, the mechanism of pigmentation caused by anticancer drugs remains unknown. The purpose of this study was to elucidate the mechanism of anticancer drug-induced skin pigmentation using 5-fluorouracil (5-FU), a widely used anticancer drug. Specific pathogen-free, 9-week-old Hos:HRM-2 male mice were intraperitoneally administered 5-FU daily for 8 weeks. Skin pigmentation was observed at the end of the study. Mice treated with 5-FU were also administered inhibitors of cAMP, α-melanocyte-stimulating hormone (α-MSH), and adrenocorticotropic hormone (ACTH) for analysis. Administration of oxidative stress, nuclear factor-kappa B (NF-κB), cAMP, and ACTH inhibitors reduced pigmentation in 5-FU-treated mice. These results indicate that the oxidative stress/NF-κB/ACTH/cAMP/tyrosinase pathway plays an important role in pigmentation in 5-FU-treated mice. |
| doi_str_mv | 10.1248/bpb.b23-00108 |
| format | Article |
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However, the mechanism of pigmentation caused by anticancer drugs remains unknown. The purpose of this study was to elucidate the mechanism of anticancer drug-induced skin pigmentation using 5-fluorouracil (5-FU), a widely used anticancer drug. Specific pathogen-free, 9-week-old Hos:HRM-2 male mice were intraperitoneally administered 5-FU daily for 8 weeks. Skin pigmentation was observed at the end of the study. Mice treated with 5-FU were also administered inhibitors of cAMP, α-melanocyte-stimulating hormone (α-MSH), and adrenocorticotropic hormone (ACTH) for analysis. Administration of oxidative stress, nuclear factor-kappa B (NF-κB), cAMP, and ACTH inhibitors reduced pigmentation in 5-FU-treated mice. These results indicate that the oxidative stress/NF-κB/ACTH/cAMP/tyrosinase pathway plays an important role in pigmentation in 5-FU-treated mice.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b23-00108</identifier><identifier>PMID: 37197927</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>5-Fluorouracil ; Adrenocorticotropic Hormone ; alpha-MSH - pharmacology ; Animals ; Antineoplastic Agents ; Antineoplastic drugs ; Antitumor agents ; cAMP ; Cyclic AMP ; Fluorouracil - adverse effects ; Male ; Melanocyte-stimulating hormone ; Mice ; NF-kappa B - metabolism ; NF-κB protein ; nuclear factor-kappa B ; Oxidative stress ; Quality of Life ; reactive oxygen species ; Skin ; Skin Pigmentation ; Specific pathogen free ; tyrosinase</subject><ispartof>Biological and Pharmaceutical Bulletin, 2023/07/01, Vol.46(7), pp.955-963</ispartof><rights>2023 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-c892d15351333766cc623b142edc914a8a0e6cb5c56b36a1ad250d14e7eb06f23</citedby><cites>FETCH-LOGICAL-c567t-c892d15351333766cc623b142edc914a8a0e6cb5c56b36a1ad250d14e7eb06f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37197927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujito, Atsuo</creatorcontrib><creatorcontrib>Hiramoto, Keiichi</creatorcontrib><creatorcontrib>Imai, Masashi</creatorcontrib><creatorcontrib>Tanaka, Shota</creatorcontrib><creatorcontrib>Ooi, Kazuya</creatorcontrib><title>ACTH/cAMP-Mediated Skin Pigmentation Caused by 5-Fluorouracil Administration</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Anticancer drugs exhibit many side effects, including skin pigmentation, which often lowers patient QOL. However, the mechanism of pigmentation caused by anticancer drugs remains unknown. The purpose of this study was to elucidate the mechanism of anticancer drug-induced skin pigmentation using 5-fluorouracil (5-FU), a widely used anticancer drug. Specific pathogen-free, 9-week-old Hos:HRM-2 male mice were intraperitoneally administered 5-FU daily for 8 weeks. Skin pigmentation was observed at the end of the study. Mice treated with 5-FU were also administered inhibitors of cAMP, α-melanocyte-stimulating hormone (α-MSH), and adrenocorticotropic hormone (ACTH) for analysis. Administration of oxidative stress, nuclear factor-kappa B (NF-κB), cAMP, and ACTH inhibitors reduced pigmentation in 5-FU-treated mice. These results indicate that the oxidative stress/NF-κB/ACTH/cAMP/tyrosinase pathway plays an important role in pigmentation in 5-FU-treated mice.</description><subject>5-Fluorouracil</subject><subject>Adrenocorticotropic Hormone</subject><subject>alpha-MSH - pharmacology</subject><subject>Animals</subject><subject>Antineoplastic Agents</subject><subject>Antineoplastic drugs</subject><subject>Antitumor agents</subject><subject>cAMP</subject><subject>Cyclic AMP</subject><subject>Fluorouracil - adverse effects</subject><subject>Male</subject><subject>Melanocyte-stimulating hormone</subject><subject>Mice</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>nuclear factor-kappa B</subject><subject>Oxidative stress</subject><subject>Quality of Life</subject><subject>reactive oxygen species</subject><subject>Skin</subject><subject>Skin Pigmentation</subject><subject>Specific pathogen free</subject><subject>tyrosinase</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0LtPwzAQBnALgaA8RlYUiYXFxWfHdjJWES-pFUjAbNmOCy55FDsZ-O8xLXRguRvup0-nD6FzIFOgeXFt1mZqKMOEACn20ARYLjGnwPfRhJRQYAG8OELHMa4IIZJQdoiOmIRSllRO0HxWvdxf29niCS9c7fXg6uz5w3fZk39rXTfowfddVukxpoP5yji-bcY-9GPQ1jfZrG595-MQNu4UHSx1E93Z7z5Br7c3L9U9nj_ePVSzObZcyAHboqQ1cMaBMSaFsFZQZiCnrrYl5LrQxAlreNKGCQ26ppzUkDvpDBFLyk7Q1TZ3HfrP0cVBtT5a1zS6c_0YFS2A07wUUiR6-Y-u0u9d-i4pTnJBhYCk8FbZ0McY3FKtg291-FJA1E_NKtWsUs1qU3PyF7-po2ldvdN_vSZQbcEqDvrN7YAOg7eN28TlQsmfsYvdXe27Dsp17BsXWo5Q</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Fujito, Atsuo</creator><creator>Hiramoto, Keiichi</creator><creator>Imai, Masashi</creator><creator>Tanaka, Shota</creator><creator>Ooi, Kazuya</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20230701</creationdate><title>ACTH/cAMP-Mediated Skin Pigmentation Caused by 5-Fluorouracil Administration</title><author>Fujito, Atsuo ; Hiramoto, Keiichi ; Imai, Masashi ; Tanaka, Shota ; Ooi, Kazuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-c892d15351333766cc623b142edc914a8a0e6cb5c56b36a1ad250d14e7eb06f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>5-Fluorouracil</topic><topic>Adrenocorticotropic Hormone</topic><topic>alpha-MSH - pharmacology</topic><topic>Animals</topic><topic>Antineoplastic Agents</topic><topic>Antineoplastic drugs</topic><topic>Antitumor agents</topic><topic>cAMP</topic><topic>Cyclic AMP</topic><topic>Fluorouracil - adverse effects</topic><topic>Male</topic><topic>Melanocyte-stimulating hormone</topic><topic>Mice</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB protein</topic><topic>nuclear factor-kappa B</topic><topic>Oxidative stress</topic><topic>Quality of Life</topic><topic>reactive oxygen species</topic><topic>Skin</topic><topic>Skin Pigmentation</topic><topic>Specific pathogen free</topic><topic>tyrosinase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujito, Atsuo</creatorcontrib><creatorcontrib>Hiramoto, Keiichi</creatorcontrib><creatorcontrib>Imai, Masashi</creatorcontrib><creatorcontrib>Tanaka, Shota</creatorcontrib><creatorcontrib>Ooi, Kazuya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujito, Atsuo</au><au>Hiramoto, Keiichi</au><au>Imai, Masashi</au><au>Tanaka, Shota</au><au>Ooi, Kazuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ACTH/cAMP-Mediated Skin Pigmentation Caused by 5-Fluorouracil Administration</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>46</volume><issue>7</issue><spage>955</spage><epage>963</epage><pages>955-963</pages><artnum>b23-00108</artnum><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Anticancer drugs exhibit many side effects, including skin pigmentation, which often lowers patient QOL. However, the mechanism of pigmentation caused by anticancer drugs remains unknown. The purpose of this study was to elucidate the mechanism of anticancer drug-induced skin pigmentation using 5-fluorouracil (5-FU), a widely used anticancer drug. Specific pathogen-free, 9-week-old Hos:HRM-2 male mice were intraperitoneally administered 5-FU daily for 8 weeks. Skin pigmentation was observed at the end of the study. Mice treated with 5-FU were also administered inhibitors of cAMP, α-melanocyte-stimulating hormone (α-MSH), and adrenocorticotropic hormone (ACTH) for analysis. Administration of oxidative stress, nuclear factor-kappa B (NF-κB), cAMP, and ACTH inhibitors reduced pigmentation in 5-FU-treated mice. These results indicate that the oxidative stress/NF-κB/ACTH/cAMP/tyrosinase pathway plays an important role in pigmentation in 5-FU-treated mice.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>37197927</pmid><doi>10.1248/bpb.b23-00108</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 5-Fluorouracil Adrenocorticotropic Hormone alpha-MSH - pharmacology Animals Antineoplastic Agents Antineoplastic drugs Antitumor agents cAMP Cyclic AMP Fluorouracil - adverse effects Male Melanocyte-stimulating hormone Mice NF-kappa B - metabolism NF-κB protein nuclear factor-kappa B Oxidative stress Quality of Life reactive oxygen species Skin Skin Pigmentation Specific pathogen free tyrosinase |
| title | ACTH/cAMP-Mediated Skin Pigmentation Caused by 5-Fluorouracil Administration |
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