Leukocyte-Rich Platelet-Rich Plasma Is Predominantly Anti-inflammatory Compared With Leukocyte-Poor Platelet-Rich Plasma in Patients With Mild-Moderate Knee Osteoarthritis: A Prospective, Descriptive Laboratory Study

Background: Platelet-rich plasma (PRP) has been used extensively in clinical practice to treat patients with symptomatic knee osteoarthritis (OA). Leukocyte-poor PRP (LP-PRP) has been clinically preferred over leukocyte-rich PRP (LR-PRP); however, it is unclear which cytokine mediators of pain and i...

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Veröffentlicht in:	The American journal of sports medicine 2023-07, Vol.51 (8), p.2133-2140
Hauptverfasser:	Jayaram, Prathap, Mitchell, Parker J.T., Shybut, Theodore B., Moseley, Bruce J., Lee, Brendan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents Arthritis Blood Blood platelets Cytokines Female Humans Inflammation Inflammation - metabolism Interleukin 1 Receptor Antagonist Protein - metabolism Interleukin-10 - metabolism Interleukin-4 - metabolism Interleukin-6 - metabolism Interleukin-8 - metabolism Knee Laboratories Leukocytes Leukocytes - metabolism Male Matrix Metalloproteinase 9 - metabolism Nerve Growth Factor - metabolism Osteoarthritis Osteoarthritis, Knee - metabolism Osteoarthritis, Knee - therapy Platelet-Rich Plasma - metabolism Prospective Studies Sports medicine Treatment Outcome Tumor Necrosis Factor-alpha - metabolism
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