Caution may be required in using l-theanine in diabetes mellitus: A study on the rats

The study aimed to identify the effects of l-theanine on kidney and heart tissues in diabetic rats. 24 male rats included in the study were divided into 4 groups (n = 6/group): SHAM, LTEA, DM and DM + LTEA. For 28 days, drinking water was given to SHAM and DM, and LTEA (200 mg/kg/day) to LTEA and DM...

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Veröffentlicht in:	Biochemical and biophysical research communications 2023-07, Vol.666, p.170-178
Hauptverfasser:	Vanizor Kural, Birgül, Azi Mohamed, Sabrina, Kör, Sevil, Arıkan Malkoç, Meltem, Yuluğ, Esin, Hajizadeh Tekmeh, Hamed, Örem, Asım
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Animals Cystatin C Diabetes Diabetes Mellitus, Experimental - metabolism Glutamates - pharmacology Glutathione Disulfide - metabolism Homocysteine Iron Kidney - pathology L-theanine Male Rats Rats, Sprague-Dawley Streptozocin
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Beschreibung
Zusammenfassung:	The study aimed to identify the effects of l-theanine on kidney and heart tissues in diabetic rats. 24 male rats included in the study were divided into 4 groups (n = 6/group): SHAM, LTEA, DM and DM + LTEA. For 28 days, drinking water was given to SHAM and DM, and LTEA (200 mg/kg/day) to LTEA and DM + LTEA groups, intragastrically. DM was induced by 120 mg/kg nicotinamide (NA) + 60 mg/kg streptozotocin (STZ). The levels of cystatin C (CysC) and angiotensin-converting enzyme 2 (ACE2) were determined by ELISA kits, homocysteine, electrolytes and iron by an autoanalyzer, the ratio of oxidized/total reduced glutathione (GSSG/TGSH) by assay kits. The tissues were histopathologically analyzed. LTEA alleviated histopathological degenerations. However, it decreased significantly serum iron and homocysteine levels (p
ISSN:	0006-291X 1090-2104
DOI:	10.1016/j.bbrc.2023.04.095