Dendritic Poly-[N-(2-Hydroxyethyl)-L-Glutamine] as Potential Drug Carrier

Dendritic Poly-[N-(2-Hydroxyethyl)-L-Glutamine] as Potential Drug Carrier

Dendritic poly-[N-(2-hydroxyethyl)-L-glutamine] (PHEG) with different molecular weights were synthesized by aminolysis of dendritic poly-(γ-benzyl-L-glutamate) (PBG), which was obtained by polymerization of the corresponding N-carboxyanhydride (NCA) with poly(amido amine) (PAMAM, starburst®) of the...

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Veröffentlicht in:Journal of bioactive and compatible polymers 2004-09, Vol.19 (5), p.367-382
Hauptverfasser: de Winne, Katleen, Vanderkerken, Sylvie, Hoste, Katty, Dubruel, Peter, Schacht, Etienne, Jelinkova, Marketa, Rihova, Blanka
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container_end_page 382
container_issue 5
container_start_page 367
container_title Journal of bioactive and compatible polymers
container_volume 19
creator de Winne, Katleen
Vanderkerken, Sylvie
Hoste, Katty
Dubruel, Peter
Schacht, Etienne
Jelinkova, Marketa
Rihova, Blanka
description Dendritic poly-[N-(2-hydroxyethyl)-L-glutamine] (PHEG) with different molecular weights were synthesized by aminolysis of dendritic poly-(γ-benzyl-L-glutamate) (PBG), which was obtained by polymerization of the corresponding N-carboxyanhydride (NCA) with poly(amido amine) (PAMAM, starburst®) of the fourth generation as initiator. Dynamic light scattering (DLS) was used to determine the size of the polymeric carriers and to compare the dendritic polymer to the linear analogue. The body distribution and blood clearance of 125 I-radiolabelled linear and dendritic PHEG with similar molecular weight were investigated in female BALB/c mice.
doi_str_mv 10.1177/0883911504046680
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