SQSTM1/P62 promotes lysophagy via formation of liquid-like condensates maintained by HSP27

Injury to the lysosome engages a series of quality control mechanisms that mitigate cellular stress. One such mechanism is the degradation of these organelles by lysophagy, the selective autophagy of damaged lysosomes. In recent work, we have shown a requirement for the selective autophagy receptor...

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Veröffentlicht in:	Autophagy 2023-11, Vol.19 (11), p.3029-3030
Hauptverfasser:	Gallagher, Elizabeth R., Holzbaur, Erika L.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic Lateral Sclerosis - metabolism Autophagic Punctum Autophagy HSP27 HSP27 Heat-Shock Proteins - metabolism Humans lysophagy Lysosomes Macroautophagy neurodegeneration phase separation Sequestosome-1 Protein - metabolism Sqstm1/P62
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