Tocilizumab increases regulatory T cells, reduces natural killer cells and delays graft‐versus‐host disease development in humanized mice treated with post‐transplant cyclophosphamide

Graft‐versus‐host disease (GVHD) is a life‐threatening complication following donor hematopoietic stem cell transplantation, where donor T cells damage host tissues. This study investigated the effect of tocilizumab (TOC) combined with post‐transplant cyclophosphamide (PTCy) on immune cell engraftme...

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Veröffentlicht in:	Immunology and cell biology 2023-08, Vol.101 (7), p.639-656
Hauptverfasser:	Sligar, Chloe, Cuthbertson, Peter, Miles, Nicole A, Adhikary, Sam R, Elhage, Amal, Zhang, Geoff, Alexander, Stephen I, Sluyter, Ronald, Watson, Debbie
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclophosphamide Graft-versus-host reaction Hematopoietic stem cells Humanized mice Immunoregulation Leukocytes Leukocytes (mononuclear) Lymphocytes Lymphocytes T Monoclonal antibodies Natural killer cells Peripheral blood mononuclear cells post‐transplant cyclophosphamide regulatory T cells Spleen Stem cell transplantation tocilizumab Transplants & implants xenogeneic graft‐versus‐host disease Xenografts
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