An integrated analysis of mRNAs and lncRNAs in goat's hypothalamus to explore the onset of puberty
The time of puberty onset is crucial for female animal, as it can affect the generation interval, feeding costs and the utilization of animals. However, little is known about the mechanism of hypothalamic lncRNAs (long noncoding RNAs) in regulatory goat puberty onset. Therefore, genome‐wide transcri...
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| Veröffentlicht in: | Reproduction in domestic animals 2023-08, Vol.58 (8), p.1046-1054 |
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| container_title | Reproduction in domestic animals |
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| creator | Gao, Xiaoxiao Ren, Chunhuan Zhang, Wei Fang, Fugui |
| description | The time of puberty onset is crucial for female animal, as it can affect the generation interval, feeding costs and the utilization of animals. However, little is known about the mechanism of hypothalamic lncRNAs (long noncoding RNAs) in regulatory goat puberty onset. Therefore, genome‐wide transcriptome analysis was performed in goats to clarify the roles of hypothalamic lncRNAs and mRNAs in the onset of puberty. In the present study, the co‐expression network of differentially expressed (DE) mRNAs in goat hypothalamus identified FN1 as the hub gene, and ECM‐receptor interaction, Focal adhesion and PI3K‐Akt signalling pathways are involved in puberty. We also observed the crucial hub transcription factors (TCF12, STAT1, STAT2, GATA3 and TEAD4) associated with reproduction and puberty. Then, genetic correlation analysis of DE mRNAs and DE lncRNAs identified the key lncRNAs involved in puberty. This research supplies a resource for transcriptome studies in goat puberty and indicated DE lncRNAs in the ECM‐receptor interaction pathway were novel candidate regulators for genetic studies on female reproduction. |
| doi_str_mv | 10.1111/rda.14389 |
| format | Article |
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However, little is known about the mechanism of hypothalamic lncRNAs (long noncoding RNAs) in regulatory goat puberty onset. Therefore, genome‐wide transcriptome analysis was performed in goats to clarify the roles of hypothalamic lncRNAs and mRNAs in the onset of puberty. In the present study, the co‐expression network of differentially expressed (DE) mRNAs in goat hypothalamus identified FN1 as the hub gene, and ECM‐receptor interaction, Focal adhesion and PI3K‐Akt signalling pathways are involved in puberty. We also observed the crucial hub transcription factors (TCF12, STAT1, STAT2, GATA3 and TEAD4) associated with reproduction and puberty. Then, genetic correlation analysis of DE mRNAs and DE lncRNAs identified the key lncRNAs involved in puberty. This research supplies a resource for transcriptome studies in goat puberty and indicated DE lncRNAs in the ECM‐receptor interaction pathway were novel candidate regulators for genetic studies on female reproduction.</description><identifier>ISSN: 0936-6768</identifier><identifier>EISSN: 1439-0531</identifier><identifier>DOI: 10.1111/rda.14389</identifier><identifier>PMID: 37191523</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>1-Phosphatidylinositol 3-kinase ; AKT protein ; Correlation analysis ; Extracellular matrix ; Females ; GATA-3 protein ; Genetic analysis ; Genomes ; goat ; Goats ; Hypothalamus ; long noncoding RNA ; Non-coding RNA ; Puberty ; Receptors ; reproduction ; Signal transduction ; Stat1 protein ; Stat2 protein ; Transcription factors ; Transcriptomes</subject><ispartof>Reproduction in domestic animals, 2023-08, Vol.58 (8), p.1046-1054</ispartof><rights>2023 Wiley‐VCH GmbH.</rights><rights>2023 Wiley-VCH GmbH.</rights><rights>Copyright © 2023 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3139-5e7d990666bd114dc937e8cc6ef545bdc58f82d02834d7690ddb029f17a68bf63</cites><orcidid>0000-0001-6874-6376 ; 0000-0002-3203-6687 ; 0000-0002-1704-059X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Frda.14389$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Frda.14389$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37191523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Xiaoxiao</creatorcontrib><creatorcontrib>Ren, Chunhuan</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Fang, Fugui</creatorcontrib><title>An integrated analysis of mRNAs and lncRNAs in goat's hypothalamus to explore the onset of puberty</title><title>Reproduction in domestic animals</title><addtitle>Reprod Domest Anim</addtitle><description>The time of puberty onset is crucial for female animal, as it can affect the generation interval, feeding costs and the utilization of animals. However, little is known about the mechanism of hypothalamic lncRNAs (long noncoding RNAs) in regulatory goat puberty onset. Therefore, genome‐wide transcriptome analysis was performed in goats to clarify the roles of hypothalamic lncRNAs and mRNAs in the onset of puberty. In the present study, the co‐expression network of differentially expressed (DE) mRNAs in goat hypothalamus identified FN1 as the hub gene, and ECM‐receptor interaction, Focal adhesion and PI3K‐Akt signalling pathways are involved in puberty. We also observed the crucial hub transcription factors (TCF12, STAT1, STAT2, GATA3 and TEAD4) associated with reproduction and puberty. Then, genetic correlation analysis of DE mRNAs and DE lncRNAs identified the key lncRNAs involved in puberty. This research supplies a resource for transcriptome studies in goat puberty and indicated DE lncRNAs in the ECM‐receptor interaction pathway were novel candidate regulators for genetic studies on female reproduction.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>AKT protein</subject><subject>Correlation analysis</subject><subject>Extracellular matrix</subject><subject>Females</subject><subject>GATA-3 protein</subject><subject>Genetic analysis</subject><subject>Genomes</subject><subject>goat</subject><subject>Goats</subject><subject>Hypothalamus</subject><subject>long noncoding RNA</subject><subject>Non-coding RNA</subject><subject>Puberty</subject><subject>Receptors</subject><subject>reproduction</subject><subject>Signal transduction</subject><subject>Stat1 protein</subject><subject>Stat2 protein</subject><subject>Transcription factors</subject><subject>Transcriptomes</subject><issn>0936-6768</issn><issn>1439-0531</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kEtP3DAURi1UVAboon-gstQFdDFgx_FrOeLRIiGQRrCOnPhmJiiJU9sRzb_H86ALJLzwZ1lHR_d-CH2n5IKmc-mtuaA5U_oAzVLqOeGMfkEzopmYCynUEToO4YUQypWUX9ERk1RTnrEZKhc9bvoIK28iWGx6006hCdjVuFs-LEL6sbjtq-276fHKmXgW8HoaXFyb1nRjwNFh-De0zgOOa8CuDxA3gmEswcfpFB3Wpg3wbZ8n6Pn25unqz_z-8ffd1eJ-XjGaZuYgrdZECFFaSnNbaSZBVZWAmue8tBVXtcosyRTLrRSaWFuSTNdUGqHKWrATdL7zDt79HSHEomtCBW1renBjKDJFc54uQhP68wP64kafdt9QOc8ZEzJP1K8dVXkXgoe6GHzTGT8VlBSb4otUfLEtPrE_9sax7MD-J9-bTsDlDnhtWpg-NxXL68VO-QbpiIug</recordid><startdate>202308</startdate><enddate>202308</enddate><creator>Gao, Xiaoxiao</creator><creator>Ren, Chunhuan</creator><creator>Zhang, Wei</creator><creator>Fang, Fugui</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6874-6376</orcidid><orcidid>https://orcid.org/0000-0002-3203-6687</orcidid><orcidid>https://orcid.org/0000-0002-1704-059X</orcidid></search><sort><creationdate>202308</creationdate><title>An integrated analysis of mRNAs and lncRNAs in goat's hypothalamus to explore the onset of puberty</title><author>Gao, Xiaoxiao ; Ren, Chunhuan ; Zhang, Wei ; Fang, Fugui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3139-5e7d990666bd114dc937e8cc6ef545bdc58f82d02834d7690ddb029f17a68bf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>AKT protein</topic><topic>Correlation analysis</topic><topic>Extracellular matrix</topic><topic>Females</topic><topic>GATA-3 protein</topic><topic>Genetic analysis</topic><topic>Genomes</topic><topic>goat</topic><topic>Goats</topic><topic>Hypothalamus</topic><topic>long noncoding RNA</topic><topic>Non-coding RNA</topic><topic>Puberty</topic><topic>Receptors</topic><topic>reproduction</topic><topic>Signal transduction</topic><topic>Stat1 protein</topic><topic>Stat2 protein</topic><topic>Transcription factors</topic><topic>Transcriptomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Xiaoxiao</creatorcontrib><creatorcontrib>Ren, Chunhuan</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Fang, Fugui</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Reproduction in domestic animals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Xiaoxiao</au><au>Ren, Chunhuan</au><au>Zhang, Wei</au><au>Fang, Fugui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An integrated analysis of mRNAs and lncRNAs in goat's hypothalamus to explore the onset of puberty</atitle><jtitle>Reproduction in domestic animals</jtitle><addtitle>Reprod Domest Anim</addtitle><date>2023-08</date><risdate>2023</risdate><volume>58</volume><issue>8</issue><spage>1046</spage><epage>1054</epage><pages>1046-1054</pages><issn>0936-6768</issn><eissn>1439-0531</eissn><abstract>The time of puberty onset is crucial for female animal, as it can affect the generation interval, feeding costs and the utilization of animals. However, little is known about the mechanism of hypothalamic lncRNAs (long noncoding RNAs) in regulatory goat puberty onset. Therefore, genome‐wide transcriptome analysis was performed in goats to clarify the roles of hypothalamic lncRNAs and mRNAs in the onset of puberty. In the present study, the co‐expression network of differentially expressed (DE) mRNAs in goat hypothalamus identified FN1 as the hub gene, and ECM‐receptor interaction, Focal adhesion and PI3K‐Akt signalling pathways are involved in puberty. We also observed the crucial hub transcription factors (TCF12, STAT1, STAT2, GATA3 and TEAD4) associated with reproduction and puberty. Then, genetic correlation analysis of DE mRNAs and DE lncRNAs identified the key lncRNAs involved in puberty. This research supplies a resource for transcriptome studies in goat puberty and indicated DE lncRNAs in the ECM‐receptor interaction pathway were novel candidate regulators for genetic studies on female reproduction.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>37191523</pmid><doi>10.1111/rda.14389</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6874-6376</orcidid><orcidid>https://orcid.org/0000-0002-3203-6687</orcidid><orcidid>https://orcid.org/0000-0002-1704-059X</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | 1-Phosphatidylinositol 3-kinase AKT protein Correlation analysis Extracellular matrix Females GATA-3 protein Genetic analysis Genomes goat Goats Hypothalamus long noncoding RNA Non-coding RNA Puberty Receptors reproduction Signal transduction Stat1 protein Stat2 protein Transcription factors Transcriptomes |
| title | An integrated analysis of mRNAs and lncRNAs in goat's hypothalamus to explore the onset of puberty |
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