Work-related psychosocial factors and inflammatory markers: A systematic review and meta-analysis
We conducted a systematic review and meta-analysis to evaluate the prospective effect of adverse work-related psychosocial factors on increases in inflammatory markers. A systematic literature search was conducted in PubMed, Embase, PsycINFO, PsycARTICLES, and the Japan Medical Abstracts Society dat...
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| Veröffentlicht in: | Journal of psychosomatic research 2023-07, Vol.170, p.111349-111349, Article 111349 |
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| creator | Eguchi, Hisashi Watanabe, Kazuhiro Kawakami, Norito Ando, Emiko Imamura, Kotaro Sakuraya, Asuka Sasaki, Natsu Inoue, Akiomi Tsuno, Kanami Otsuka, Yasumasa Inoue, Reiko Nishida, Norimitsu Iwanaga, Mai Hino, Ayako Shimazu, Akihito Tsutsumi, Akizumi |
| description | We conducted a systematic review and meta-analysis to evaluate the prospective effect of adverse work-related psychosocial factors on increases in inflammatory markers.
A systematic literature search was conducted in PubMed, Embase, PsycINFO, PsycARTICLES, and the Japan Medical Abstracts Society database. Studies were eligible for inclusion if they examined associations between work-related psychosocial factors and inflammatory markers (interleukin-6, tumor necrosis factor-alpha, and C-reactive protein), used longitudinal or prospective cohort designs, were conducted among workers, were original articles written in English or Japanese, and were published up to 2017 for the first search, October 2020 for the second, and November 2022 for the third. A meta-analysis was conducted using a random-effects model to assess the pooled effect size for the associations. A meta-regression analysis was used to estimate the association between length of follow-up and effect size. The ROBINS-I tool was used to assess risk of bias.
Of the 11,121 studies identified in the first search, 29,135 studies from the second, and 9448 studies from the third, eleven were eligible for this review and meta-analysis. The pooled coefficient between adverse work-related psychosocial factors and inflammatory markers was significant and positive (β = 0.014, 95% confidence interval: 0.005–0.023). However, a clear association was only observed for interleukin-6, and all the studies included had serious risks of bias. Meta-regression showed the effect size decreased depending on the follow-up period.
This study revealed a weak positive association between adverse work-related psychosocial factors and increases in inflammatory markers.
Trial registration: PROSPERO CRD42018081553 (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=81553).
•We evaluated impact of work-related psychosocial factors on inflammatory markers.•The inflammatory markers included CRP, TNF-α, and IL-6.•The eleven research were eligible for the review and meta-analysis.•Adverse work-related psychosocial factors positively associated with increased inflammatory markers.•The association between length of follow-up and effect size was slightly negative. |
| doi_str_mv | 10.1016/j.jpsychores.2023.111349 |
| format | Article |
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A systematic literature search was conducted in PubMed, Embase, PsycINFO, PsycARTICLES, and the Japan Medical Abstracts Society database. Studies were eligible for inclusion if they examined associations between work-related psychosocial factors and inflammatory markers (interleukin-6, tumor necrosis factor-alpha, and C-reactive protein), used longitudinal or prospective cohort designs, were conducted among workers, were original articles written in English or Japanese, and were published up to 2017 for the first search, October 2020 for the second, and November 2022 for the third. A meta-analysis was conducted using a random-effects model to assess the pooled effect size for the associations. A meta-regression analysis was used to estimate the association between length of follow-up and effect size. The ROBINS-I tool was used to assess risk of bias.
Of the 11,121 studies identified in the first search, 29,135 studies from the second, and 9448 studies from the third, eleven were eligible for this review and meta-analysis. The pooled coefficient between adverse work-related psychosocial factors and inflammatory markers was significant and positive (β = 0.014, 95% confidence interval: 0.005–0.023). However, a clear association was only observed for interleukin-6, and all the studies included had serious risks of bias. Meta-regression showed the effect size decreased depending on the follow-up period.
This study revealed a weak positive association between adverse work-related psychosocial factors and increases in inflammatory markers.
Trial registration: PROSPERO CRD42018081553 (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=81553).
•We evaluated impact of work-related psychosocial factors on inflammatory markers.•The inflammatory markers included CRP, TNF-α, and IL-6.•The eleven research were eligible for the review and meta-analysis.•Adverse work-related psychosocial factors positively associated with increased inflammatory markers.•The association between length of follow-up and effect size was slightly negative.</description><identifier>ISSN: 0022-3999</identifier><identifier>EISSN: 1879-1360</identifier><identifier>DOI: 10.1016/j.jpsychores.2023.111349</identifier><identifier>PMID: 37187013</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>C-reactive protein ; Humans ; Interleukin-6 ; Japan ; Meta-analysis ; Prospective Studies ; Psychosocial factor ; Tumor necrosis factor-alpha ; Workplace</subject><ispartof>Journal of psychosomatic research, 2023-07, Vol.170, p.111349-111349, Article 111349</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c369t-3612dcd9e0fd74f452c8cf14a5f67cad109525f9049a8d9ab9c425936603b2ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpsychores.2023.111349$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37187013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eguchi, Hisashi</creatorcontrib><creatorcontrib>Watanabe, Kazuhiro</creatorcontrib><creatorcontrib>Kawakami, Norito</creatorcontrib><creatorcontrib>Ando, Emiko</creatorcontrib><creatorcontrib>Imamura, Kotaro</creatorcontrib><creatorcontrib>Sakuraya, Asuka</creatorcontrib><creatorcontrib>Sasaki, Natsu</creatorcontrib><creatorcontrib>Inoue, Akiomi</creatorcontrib><creatorcontrib>Tsuno, Kanami</creatorcontrib><creatorcontrib>Otsuka, Yasumasa</creatorcontrib><creatorcontrib>Inoue, Reiko</creatorcontrib><creatorcontrib>Nishida, Norimitsu</creatorcontrib><creatorcontrib>Iwanaga, Mai</creatorcontrib><creatorcontrib>Hino, Ayako</creatorcontrib><creatorcontrib>Shimazu, Akihito</creatorcontrib><creatorcontrib>Tsutsumi, Akizumi</creatorcontrib><title>Work-related psychosocial factors and inflammatory markers: A systematic review and meta-analysis</title><title>Journal of psychosomatic research</title><addtitle>J Psychosom Res</addtitle><description>We conducted a systematic review and meta-analysis to evaluate the prospective effect of adverse work-related psychosocial factors on increases in inflammatory markers.
A systematic literature search was conducted in PubMed, Embase, PsycINFO, PsycARTICLES, and the Japan Medical Abstracts Society database. Studies were eligible for inclusion if they examined associations between work-related psychosocial factors and inflammatory markers (interleukin-6, tumor necrosis factor-alpha, and C-reactive protein), used longitudinal or prospective cohort designs, were conducted among workers, were original articles written in English or Japanese, and were published up to 2017 for the first search, October 2020 for the second, and November 2022 for the third. A meta-analysis was conducted using a random-effects model to assess the pooled effect size for the associations. A meta-regression analysis was used to estimate the association between length of follow-up and effect size. The ROBINS-I tool was used to assess risk of bias.
Of the 11,121 studies identified in the first search, 29,135 studies from the second, and 9448 studies from the third, eleven were eligible for this review and meta-analysis. The pooled coefficient between adverse work-related psychosocial factors and inflammatory markers was significant and positive (β = 0.014, 95% confidence interval: 0.005–0.023). However, a clear association was only observed for interleukin-6, and all the studies included had serious risks of bias. Meta-regression showed the effect size decreased depending on the follow-up period.
This study revealed a weak positive association between adverse work-related psychosocial factors and increases in inflammatory markers.
Trial registration: PROSPERO CRD42018081553 (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=81553).
•We evaluated impact of work-related psychosocial factors on inflammatory markers.•The inflammatory markers included CRP, TNF-α, and IL-6.•The eleven research were eligible for the review and meta-analysis.•Adverse work-related psychosocial factors positively associated with increased inflammatory markers.•The association between length of follow-up and effect size was slightly negative.</description><subject>C-reactive protein</subject><subject>Humans</subject><subject>Interleukin-6</subject><subject>Japan</subject><subject>Meta-analysis</subject><subject>Prospective Studies</subject><subject>Psychosocial factor</subject><subject>Tumor necrosis factor-alpha</subject><subject>Workplace</subject><issn>0022-3999</issn><issn>1879-1360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOHDEQRS0EggnwC8jLbHriR3dPm90EkYeExAbE0qqxy8Iz_Zi4eoj672NoSJZZlVQ695bqMMalWEoh6y_b5XZPk3seEtJSCaWXUkpdmiO2kM3KFFLX4pgthFCq0MaYM_aJaCuEqI2qTtmZXmVMSL1g8DSkXZGwhRE9n0tpcBFaHsCNQyIOveexDy10HeTFxDtIO0x0zdecJhoxr6PjCV8i_n6jOxyhgB7aiSJdsJMALeHl-zxnj99uH25-FHf333_erO8Kp2szFrqWyjtvUAS_KkNZKde4IEuoQr1y4KUwlaqCEaWBxhvYGFeqyui6FnqjQtDn7PPcu0_DrwPSaLtIDtsWehwOZFUjc2mltcloM6MuDUQJg92nmL-arBT2VbDd2n-C7atgOwvO0av3K4dNh_5v8MNoBr7OAOZfs5FkyUXsHfqY0I3WD_H_V_4AMsSTbw</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Eguchi, Hisashi</creator><creator>Watanabe, Kazuhiro</creator><creator>Kawakami, Norito</creator><creator>Ando, Emiko</creator><creator>Imamura, Kotaro</creator><creator>Sakuraya, Asuka</creator><creator>Sasaki, Natsu</creator><creator>Inoue, Akiomi</creator><creator>Tsuno, Kanami</creator><creator>Otsuka, Yasumasa</creator><creator>Inoue, Reiko</creator><creator>Nishida, Norimitsu</creator><creator>Iwanaga, Mai</creator><creator>Hino, Ayako</creator><creator>Shimazu, Akihito</creator><creator>Tsutsumi, Akizumi</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202307</creationdate><title>Work-related psychosocial factors and inflammatory markers: A systematic review and meta-analysis</title><author>Eguchi, Hisashi ; Watanabe, Kazuhiro ; Kawakami, Norito ; Ando, Emiko ; Imamura, Kotaro ; Sakuraya, Asuka ; Sasaki, Natsu ; Inoue, Akiomi ; Tsuno, Kanami ; Otsuka, Yasumasa ; Inoue, Reiko ; Nishida, Norimitsu ; Iwanaga, Mai ; Hino, Ayako ; Shimazu, Akihito ; Tsutsumi, Akizumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-3612dcd9e0fd74f452c8cf14a5f67cad109525f9049a8d9ab9c425936603b2ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>C-reactive protein</topic><topic>Humans</topic><topic>Interleukin-6</topic><topic>Japan</topic><topic>Meta-analysis</topic><topic>Prospective Studies</topic><topic>Psychosocial factor</topic><topic>Tumor necrosis factor-alpha</topic><topic>Workplace</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eguchi, Hisashi</creatorcontrib><creatorcontrib>Watanabe, Kazuhiro</creatorcontrib><creatorcontrib>Kawakami, Norito</creatorcontrib><creatorcontrib>Ando, Emiko</creatorcontrib><creatorcontrib>Imamura, Kotaro</creatorcontrib><creatorcontrib>Sakuraya, Asuka</creatorcontrib><creatorcontrib>Sasaki, Natsu</creatorcontrib><creatorcontrib>Inoue, Akiomi</creatorcontrib><creatorcontrib>Tsuno, Kanami</creatorcontrib><creatorcontrib>Otsuka, Yasumasa</creatorcontrib><creatorcontrib>Inoue, Reiko</creatorcontrib><creatorcontrib>Nishida, Norimitsu</creatorcontrib><creatorcontrib>Iwanaga, Mai</creatorcontrib><creatorcontrib>Hino, Ayako</creatorcontrib><creatorcontrib>Shimazu, Akihito</creatorcontrib><creatorcontrib>Tsutsumi, Akizumi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychosomatic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eguchi, Hisashi</au><au>Watanabe, Kazuhiro</au><au>Kawakami, Norito</au><au>Ando, Emiko</au><au>Imamura, Kotaro</au><au>Sakuraya, Asuka</au><au>Sasaki, Natsu</au><au>Inoue, Akiomi</au><au>Tsuno, Kanami</au><au>Otsuka, Yasumasa</au><au>Inoue, Reiko</au><au>Nishida, Norimitsu</au><au>Iwanaga, Mai</au><au>Hino, Ayako</au><au>Shimazu, Akihito</au><au>Tsutsumi, Akizumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Work-related psychosocial factors and inflammatory markers: A systematic review and meta-analysis</atitle><jtitle>Journal of psychosomatic research</jtitle><addtitle>J Psychosom Res</addtitle><date>2023-07</date><risdate>2023</risdate><volume>170</volume><spage>111349</spage><epage>111349</epage><pages>111349-111349</pages><artnum>111349</artnum><issn>0022-3999</issn><eissn>1879-1360</eissn><abstract>We conducted a systematic review and meta-analysis to evaluate the prospective effect of adverse work-related psychosocial factors on increases in inflammatory markers.
A systematic literature search was conducted in PubMed, Embase, PsycINFO, PsycARTICLES, and the Japan Medical Abstracts Society database. Studies were eligible for inclusion if they examined associations between work-related psychosocial factors and inflammatory markers (interleukin-6, tumor necrosis factor-alpha, and C-reactive protein), used longitudinal or prospective cohort designs, were conducted among workers, were original articles written in English or Japanese, and were published up to 2017 for the first search, October 2020 for the second, and November 2022 for the third. A meta-analysis was conducted using a random-effects model to assess the pooled effect size for the associations. A meta-regression analysis was used to estimate the association between length of follow-up and effect size. The ROBINS-I tool was used to assess risk of bias.
Of the 11,121 studies identified in the first search, 29,135 studies from the second, and 9448 studies from the third, eleven were eligible for this review and meta-analysis. The pooled coefficient between adverse work-related psychosocial factors and inflammatory markers was significant and positive (β = 0.014, 95% confidence interval: 0.005–0.023). However, a clear association was only observed for interleukin-6, and all the studies included had serious risks of bias. Meta-regression showed the effect size decreased depending on the follow-up period.
This study revealed a weak positive association between adverse work-related psychosocial factors and increases in inflammatory markers.
Trial registration: PROSPERO CRD42018081553 (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=81553).
•We evaluated impact of work-related psychosocial factors on inflammatory markers.•The inflammatory markers included CRP, TNF-α, and IL-6.•The eleven research were eligible for the review and meta-analysis.•Adverse work-related psychosocial factors positively associated with increased inflammatory markers.•The association between length of follow-up and effect size was slightly negative.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>37187013</pmid><doi>10.1016/j.jpsychores.2023.111349</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | C-reactive protein Humans Interleukin-6 Japan Meta-analysis Prospective Studies Psychosocial factor Tumor necrosis factor-alpha Workplace |
| title | Work-related psychosocial factors and inflammatory markers: A systematic review and meta-analysis |
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