Role of de novo lipogenesis in inflammation and insulin resistance in Alzheimer's disease
Patients with Alzheimer's disease (AD) display both peripheral tissue and brain insulin resistance, the later could be a potential risk factor for cognitive dysfunction. While certain degree of inflammation is required for inducing insulin resistance, underlying mechanism(s) remains unclear. Ev...
Gespeichert in:
| Veröffentlicht in: | International journal of biological macromolecules 2023-07, Vol.242 (Pt 2), p.124859-124859, Article 124859 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 124859 |
|---|---|
| container_issue | Pt 2 |
| container_start_page | 124859 |
| container_title | International journal of biological macromolecules |
| container_volume | 242 |
| creator | Khan, Mohsin Ali Khan, Zaw Ali Shoeb, Fouzia Fatima, Ghizal Khan, Rizwan Hasan Khan, Mohammad M. |
| description | Patients with Alzheimer's disease (AD) display both peripheral tissue and brain insulin resistance, the later could be a potential risk factor for cognitive dysfunction. While certain degree of inflammation is required for inducing insulin resistance, underlying mechanism(s) remains unclear. Evidence from diverse research domains suggest that elevated intracellular fatty acids of de novo pathway can induce insulin resistance even without triggering inflammation; however, the effect of saturated fatty acids (SFAs) could be detrimental due the development of proinflammatory cues. In this context, evidence suggest that while lipid/fatty acid accumulation is a characteristic feature of brain pathology in AD, dysregulated de novo lipogenesis could be a potential source for lipid/fatty acid accumulation. Therefore, therapies aimed at regulating de novo lipogenesis could be effective in improving insulin sensitivity and cognitive function in patients with AD. |
| doi_str_mv | 10.1016/j.ijbiomac.2023.124859 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2814524768</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0141813023017531</els_id><sourcerecordid>2814524768</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-cc59a9e9c87ab48ff9140c0badea28f53fc2d553b0f84966d5d34c01866a6b173</originalsourceid><addsrcrecordid>eNqFkE1LAzEQQIMotlb_QtmbXrYmm2w2e7OIX1AQRA-eQjaZaMrupibbgv56U9p6FQYGZt7MMA-hKcEzggm_Xs7csnG-U3pW4ILOSMFEWR-hMRFVnWOM6TEaY8JILgjFI3QW4zJVeUnEKRrRKmGMiDF6f_EtZN5mBrLeb3zWupX_gB6ii5nrU9hWdZ0anO8z1ZtUiOs2NcKWGFSvYYvN259PcB2Ey5gZF0FFOEcnVrURLvZ5gt7u715vH_PF88PT7XyRa8rFkGtd1qqGWotKNUxYWxOGNW6UAVUIW1KrC1OWtMFWsJpzUxrKNCaCc8UbUtEJutrtXQX_tYY4yM5FDW2revDrKAtBWFmwiouE8h2qg48xgJWr4DoVviXBcqtVLuVBq9xqlTutaXC6v7FuOjB_YwePCbjZAZA-3TgIMmoHSY5xAfQgjXf_3fgF4HGNCg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2814524768</pqid></control><display><type>article</type><title>Role of de novo lipogenesis in inflammation and insulin resistance in Alzheimer's disease</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>Khan, Mohsin Ali ; Khan, Zaw Ali ; Shoeb, Fouzia ; Fatima, Ghizal ; Khan, Rizwan Hasan ; Khan, Mohammad M.</creator><creatorcontrib>Khan, Mohsin Ali ; Khan, Zaw Ali ; Shoeb, Fouzia ; Fatima, Ghizal ; Khan, Rizwan Hasan ; Khan, Mohammad M.</creatorcontrib><description>Patients with Alzheimer's disease (AD) display both peripheral tissue and brain insulin resistance, the later could be a potential risk factor for cognitive dysfunction. While certain degree of inflammation is required for inducing insulin resistance, underlying mechanism(s) remains unclear. Evidence from diverse research domains suggest that elevated intracellular fatty acids of de novo pathway can induce insulin resistance even without triggering inflammation; however, the effect of saturated fatty acids (SFAs) could be detrimental due the development of proinflammatory cues. In this context, evidence suggest that while lipid/fatty acid accumulation is a characteristic feature of brain pathology in AD, dysregulated de novo lipogenesis could be a potential source for lipid/fatty acid accumulation. Therefore, therapies aimed at regulating de novo lipogenesis could be effective in improving insulin sensitivity and cognitive function in patients with AD.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2023.124859</identifier><identifier>PMID: 37187418</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alzheimer's disease ; Cognitive dysfunction ; de novo lipogenesis ; Inflammation ; Insulin resistance</subject><ispartof>International journal of biological macromolecules, 2023-07, Vol.242 (Pt 2), p.124859-124859, Article 124859</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-cc59a9e9c87ab48ff9140c0badea28f53fc2d553b0f84966d5d34c01866a6b173</citedby><cites>FETCH-LOGICAL-c368t-cc59a9e9c87ab48ff9140c0badea28f53fc2d553b0f84966d5d34c01866a6b173</cites><orcidid>0000-0001-5973-447X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2023.124859$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37187418$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Mohsin Ali</creatorcontrib><creatorcontrib>Khan, Zaw Ali</creatorcontrib><creatorcontrib>Shoeb, Fouzia</creatorcontrib><creatorcontrib>Fatima, Ghizal</creatorcontrib><creatorcontrib>Khan, Rizwan Hasan</creatorcontrib><creatorcontrib>Khan, Mohammad M.</creatorcontrib><title>Role of de novo lipogenesis in inflammation and insulin resistance in Alzheimer's disease</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>Patients with Alzheimer's disease (AD) display both peripheral tissue and brain insulin resistance, the later could be a potential risk factor for cognitive dysfunction. While certain degree of inflammation is required for inducing insulin resistance, underlying mechanism(s) remains unclear. Evidence from diverse research domains suggest that elevated intracellular fatty acids of de novo pathway can induce insulin resistance even without triggering inflammation; however, the effect of saturated fatty acids (SFAs) could be detrimental due the development of proinflammatory cues. In this context, evidence suggest that while lipid/fatty acid accumulation is a characteristic feature of brain pathology in AD, dysregulated de novo lipogenesis could be a potential source for lipid/fatty acid accumulation. Therefore, therapies aimed at regulating de novo lipogenesis could be effective in improving insulin sensitivity and cognitive function in patients with AD.</description><subject>Alzheimer's disease</subject><subject>Cognitive dysfunction</subject><subject>de novo lipogenesis</subject><subject>Inflammation</subject><subject>Insulin resistance</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LAzEQQIMotlb_QtmbXrYmm2w2e7OIX1AQRA-eQjaZaMrupibbgv56U9p6FQYGZt7MMA-hKcEzggm_Xs7csnG-U3pW4ILOSMFEWR-hMRFVnWOM6TEaY8JILgjFI3QW4zJVeUnEKRrRKmGMiDF6f_EtZN5mBrLeb3zWupX_gB6ii5nrU9hWdZ0anO8z1ZtUiOs2NcKWGFSvYYvN259PcB2Ey5gZF0FFOEcnVrURLvZ5gt7u715vH_PF88PT7XyRa8rFkGtd1qqGWotKNUxYWxOGNW6UAVUIW1KrC1OWtMFWsJpzUxrKNCaCc8UbUtEJutrtXQX_tYY4yM5FDW2revDrKAtBWFmwiouE8h2qg48xgJWr4DoVviXBcqtVLuVBq9xqlTutaXC6v7FuOjB_YwePCbjZAZA-3TgIMmoHSY5xAfQgjXf_3fgF4HGNCg</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Khan, Mohsin Ali</creator><creator>Khan, Zaw Ali</creator><creator>Shoeb, Fouzia</creator><creator>Fatima, Ghizal</creator><creator>Khan, Rizwan Hasan</creator><creator>Khan, Mohammad M.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5973-447X</orcidid></search><sort><creationdate>20230701</creationdate><title>Role of de novo lipogenesis in inflammation and insulin resistance in Alzheimer's disease</title><author>Khan, Mohsin Ali ; Khan, Zaw Ali ; Shoeb, Fouzia ; Fatima, Ghizal ; Khan, Rizwan Hasan ; Khan, Mohammad M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-cc59a9e9c87ab48ff9140c0badea28f53fc2d553b0f84966d5d34c01866a6b173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alzheimer's disease</topic><topic>Cognitive dysfunction</topic><topic>de novo lipogenesis</topic><topic>Inflammation</topic><topic>Insulin resistance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Mohsin Ali</creatorcontrib><creatorcontrib>Khan, Zaw Ali</creatorcontrib><creatorcontrib>Shoeb, Fouzia</creatorcontrib><creatorcontrib>Fatima, Ghizal</creatorcontrib><creatorcontrib>Khan, Rizwan Hasan</creatorcontrib><creatorcontrib>Khan, Mohammad M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Mohsin Ali</au><au>Khan, Zaw Ali</au><au>Shoeb, Fouzia</au><au>Fatima, Ghizal</au><au>Khan, Rizwan Hasan</au><au>Khan, Mohammad M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of de novo lipogenesis in inflammation and insulin resistance in Alzheimer's disease</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>242</volume><issue>Pt 2</issue><spage>124859</spage><epage>124859</epage><pages>124859-124859</pages><artnum>124859</artnum><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>Patients with Alzheimer's disease (AD) display both peripheral tissue and brain insulin resistance, the later could be a potential risk factor for cognitive dysfunction. While certain degree of inflammation is required for inducing insulin resistance, underlying mechanism(s) remains unclear. Evidence from diverse research domains suggest that elevated intracellular fatty acids of de novo pathway can induce insulin resistance even without triggering inflammation; however, the effect of saturated fatty acids (SFAs) could be detrimental due the development of proinflammatory cues. In this context, evidence suggest that while lipid/fatty acid accumulation is a characteristic feature of brain pathology in AD, dysregulated de novo lipogenesis could be a potential source for lipid/fatty acid accumulation. Therefore, therapies aimed at regulating de novo lipogenesis could be effective in improving insulin sensitivity and cognitive function in patients with AD.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37187418</pmid><doi>10.1016/j.ijbiomac.2023.124859</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-5973-447X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0141-8130 |
| ispartof | International journal of biological macromolecules, 2023-07, Vol.242 (Pt 2), p.124859-124859, Article 124859 |
| issn | 0141-8130 1879-0003 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2814524768 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Alzheimer's disease Cognitive dysfunction de novo lipogenesis Inflammation Insulin resistance |
| title | Role of de novo lipogenesis in inflammation and insulin resistance in Alzheimer's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T17%3A33%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20de%20novo%20lipogenesis%20in%20inflammation%20and%20insulin%20resistance%20in%20Alzheimer's%20disease&rft.jtitle=International%20journal%20of%20biological%20macromolecules&rft.au=Khan,%20Mohsin%20Ali&rft.date=2023-07-01&rft.volume=242&rft.issue=Pt%202&rft.spage=124859&rft.epage=124859&rft.pages=124859-124859&rft.artnum=124859&rft.issn=0141-8130&rft.eissn=1879-0003&rft_id=info:doi/10.1016/j.ijbiomac.2023.124859&rft_dat=%3Cproquest_cross%3E2814524768%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2814524768&rft_id=info:pmid/37187418&rft_els_id=S0141813023017531&rfr_iscdi=true |