Chemical Tools for Studying Phosphohistidine: Generation of Selective τ‐Phosphohistidine and π‐Phosphohistidine Antibodies

Nonhydrolysable stable analogues of τ‐phosphohistidine (τ‐pHis) and π‐pHis have been designed, aided by electrostatic surface potential calculations, and subsequently synthesized. The τ‐pHis and π‐pHis analogues (phosphopyrazole 8 and pyridyl amino amide 13, respectively) were used as haptens to gen...

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