Association of abnormal glucose tolerance with liver‐related disease and cardiovascular diseases in patients with chronic hepatitis C
Aim Hepatitis C complicated by diabetes mellitus (DM) is considered a risk factor for the progression of fibrosis and development of hepatocellular carcinoma (HCC) and cardiovascular diseases. However, several studies may have lacked appropriate diagnosis of glucose intolerance. We aimed to examine...
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| Veröffentlicht in: | Hepatology research 2023-09, Vol.53 (9), p.806-814 |
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| creator | Konishi, Fumiaki Miyake, Teruki Watanabe, Takao Tokumoto, Yoshio Furukawa, Shinya Matsuura, Bunzo Yoshida, Osamu Miyazaki, Masumi Shiomi, Akihito Kanzaki, Sayaka Nakaguchi, Hironobu Nakamura, Yoshiko Imai, Yusuke Koizumi, Mitsuhito Yamamoto, Yasunori Koizumi, Yohei Hirooka, Masashi Takeshita, Eiji Kumagi, Teru Ikeda, Yoshio Abe, Masanori Hiasa, Yoichi |
| description | Aim
Hepatitis C complicated by diabetes mellitus (DM) is considered a risk factor for the progression of fibrosis and development of hepatocellular carcinoma (HCC) and cardiovascular diseases. However, several studies may have lacked appropriate diagnosis of glucose intolerance. We aimed to examine the risk associated with abnormal glucose intolerance in the development of liver‐related diseases, including HCC and complications of liver cirrhosis, such as ascites, esophageal and gastric varices, and hepatic encephalopathy, and cardiovascular diseases in patients with hepatitis C accurately diagnosed with impaired glucose tolerance.
Methods
This longitudinal retrospective study included 365 patients with chronic hepatitis C admitted to Ehime University Hospital for anti‐hepatitis C therapy between September 1991 and January 2015. Patients were classified into normal glucose tolerance (NGT), prediabetes, and DM groups based on 75‐g oral glucose tolerance test results.
Results
Both univariate and multivariate (adjusted for potential confounders) analyses revealed a significantly higher risk of developing HCC and cardiovascular events in the DM group than in the NGT group. However, in multivariate analysis, liver‐related events, particularly liver cirrhosis complications, revealed no significant association. In addition, the prediabetes group had no significant risk of any outcome.
Conclusions
Patients with hepatitis C complicated by DM, compared with patients with hepatitis C with NGT or complicated with prediabetes, have a higher risk of HCC and cardiovascular disease events, but not liver‐related events, particularly in not developing liver cirrhosis complications. Therefore, appropriate follow‐up is required for patients with hepatitis C based on their glucose tolerance status.
For diabetes mellitus, neither normal glucose tolerance nor prediabetes, is a significant risk for hepatocellular carcinoma and cardiovascular events in patients with hepatitis C. However, diabetes mellitus is not a risk for developing complications of liver cirrhosis. Therefore, appropriate follow‐up based on glucose tolerance is required for patients with hepatitis C. |
| doi_str_mv | 10.1111/hepr.13925 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2813888824</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2859872146</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3815-8b64590a49dead67eb613e5b8510b4f81a309e44dab5cd13c22535b1e31728653</originalsourceid><addsrcrecordid>eNp9kc9qFTEUh4MotlY3PoAE3BRh2vydySzLpVqhUCkK7oYzybnelNzkmsy0dOfOrc_ok5h2WhcuPJuE5OM7h_Mj5DVnR7zW8QZ3-YjLXugnZJ-bTjRMqq9P612atmmlavfIi1KuGOMdE-o52ZMdN7LvxT75eVJKsh4mnyJNawpjTHkLgX4Ls00F6ZQCZogW6Y2fNjT4a8y_f_zKGGBCR50vCBWD6KiF7Hy6hmLnAPnxq1Af6a42wDiVRWI3OUVvaR28vk--0NVL8mwNoeCrh_OAfHl_-nl11pxffPi4OjlvrDRcN2Zsle4ZqN4huLbDseUS9Wg0Z6NaGw6S9aiUg1Fbx6UVQks9cpS8E6bV8oAcLt5dTt9nLNOw9cViCBAxzWUQpi6tllAVffsPepXmHOt0ldJ93TNXbaXeLZTNqZSM62GX_Rby7cDZcBfPcBfPcB9Phd88KOdxi-4v-phHBfgC3PiAt_9RDWenny4X6R-Zp51w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2859872146</pqid></control><display><type>article</type><title>Association of abnormal glucose tolerance with liver‐related disease and cardiovascular diseases in patients with chronic hepatitis C</title><source>Wiley Online Library Journals</source><creator>Konishi, Fumiaki ; Miyake, Teruki ; Watanabe, Takao ; Tokumoto, Yoshio ; Furukawa, Shinya ; Matsuura, Bunzo ; Yoshida, Osamu ; Miyazaki, Masumi ; Shiomi, Akihito ; Kanzaki, Sayaka ; Nakaguchi, Hironobu ; Nakamura, Yoshiko ; Imai, Yusuke ; Koizumi, Mitsuhito ; Yamamoto, Yasunori ; Koizumi, Yohei ; Hirooka, Masashi ; Takeshita, Eiji ; Kumagi, Teru ; Ikeda, Yoshio ; Abe, Masanori ; Hiasa, Yoichi</creator><creatorcontrib>Konishi, Fumiaki ; Miyake, Teruki ; Watanabe, Takao ; Tokumoto, Yoshio ; Furukawa, Shinya ; Matsuura, Bunzo ; Yoshida, Osamu ; Miyazaki, Masumi ; Shiomi, Akihito ; Kanzaki, Sayaka ; Nakaguchi, Hironobu ; Nakamura, Yoshiko ; Imai, Yusuke ; Koizumi, Mitsuhito ; Yamamoto, Yasunori ; Koizumi, Yohei ; Hirooka, Masashi ; Takeshita, Eiji ; Kumagi, Teru ; Ikeda, Yoshio ; Abe, Masanori ; Hiasa, Yoichi</creatorcontrib><description>Aim
Hepatitis C complicated by diabetes mellitus (DM) is considered a risk factor for the progression of fibrosis and development of hepatocellular carcinoma (HCC) and cardiovascular diseases. However, several studies may have lacked appropriate diagnosis of glucose intolerance. We aimed to examine the risk associated with abnormal glucose intolerance in the development of liver‐related diseases, including HCC and complications of liver cirrhosis, such as ascites, esophageal and gastric varices, and hepatic encephalopathy, and cardiovascular diseases in patients with hepatitis C accurately diagnosed with impaired glucose tolerance.
Methods
This longitudinal retrospective study included 365 patients with chronic hepatitis C admitted to Ehime University Hospital for anti‐hepatitis C therapy between September 1991 and January 2015. Patients were classified into normal glucose tolerance (NGT), prediabetes, and DM groups based on 75‐g oral glucose tolerance test results.
Results
Both univariate and multivariate (adjusted for potential confounders) analyses revealed a significantly higher risk of developing HCC and cardiovascular events in the DM group than in the NGT group. However, in multivariate analysis, liver‐related events, particularly liver cirrhosis complications, revealed no significant association. In addition, the prediabetes group had no significant risk of any outcome.
Conclusions
Patients with hepatitis C complicated by DM, compared with patients with hepatitis C with NGT or complicated with prediabetes, have a higher risk of HCC and cardiovascular disease events, but not liver‐related events, particularly in not developing liver cirrhosis complications. Therefore, appropriate follow‐up is required for patients with hepatitis C based on their glucose tolerance status.
For diabetes mellitus, neither normal glucose tolerance nor prediabetes, is a significant risk for hepatocellular carcinoma and cardiovascular events in patients with hepatitis C. However, diabetes mellitus is not a risk for developing complications of liver cirrhosis. Therefore, appropriate follow‐up based on glucose tolerance is required for patients with hepatitis C.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1111/hepr.13925</identifier><identifier>PMID: 37183992</identifier><language>eng</language><publisher>Netherlands: Wiley Subscription Services, Inc</publisher><subject>Ascites ; cardiovascular disease ; Cardiovascular diseases ; Chromium ; chronic hepatitis C ; Cirrhosis ; Diabetes mellitus ; Fibrosis ; Glucose ; glucose intolerance ; Glucose tolerance ; Hepatic encephalopathy ; Hepatitis C ; Hepatocellular carcinoma ; Intolerance ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Multivariate analysis ; prediabetes ; Risk factors</subject><ispartof>Hepatology research, 2023-09, Vol.53 (9), p.806-814</ispartof><rights>2023 Japan Society of Hepatology.</rights><rights>2023 The Japan Society of Hepatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3815-8b64590a49dead67eb613e5b8510b4f81a309e44dab5cd13c22535b1e31728653</citedby><cites>FETCH-LOGICAL-c3815-8b64590a49dead67eb613e5b8510b4f81a309e44dab5cd13c22535b1e31728653</cites><orcidid>0000-0001-5634-5313 ; 0000-0002-9905-5356 ; 0000-0003-4117-339X ; 0000-0003-3008-691X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhepr.13925$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhepr.13925$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37183992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Konishi, Fumiaki</creatorcontrib><creatorcontrib>Miyake, Teruki</creatorcontrib><creatorcontrib>Watanabe, Takao</creatorcontrib><creatorcontrib>Tokumoto, Yoshio</creatorcontrib><creatorcontrib>Furukawa, Shinya</creatorcontrib><creatorcontrib>Matsuura, Bunzo</creatorcontrib><creatorcontrib>Yoshida, Osamu</creatorcontrib><creatorcontrib>Miyazaki, Masumi</creatorcontrib><creatorcontrib>Shiomi, Akihito</creatorcontrib><creatorcontrib>Kanzaki, Sayaka</creatorcontrib><creatorcontrib>Nakaguchi, Hironobu</creatorcontrib><creatorcontrib>Nakamura, Yoshiko</creatorcontrib><creatorcontrib>Imai, Yusuke</creatorcontrib><creatorcontrib>Koizumi, Mitsuhito</creatorcontrib><creatorcontrib>Yamamoto, Yasunori</creatorcontrib><creatorcontrib>Koizumi, Yohei</creatorcontrib><creatorcontrib>Hirooka, Masashi</creatorcontrib><creatorcontrib>Takeshita, Eiji</creatorcontrib><creatorcontrib>Kumagi, Teru</creatorcontrib><creatorcontrib>Ikeda, Yoshio</creatorcontrib><creatorcontrib>Abe, Masanori</creatorcontrib><creatorcontrib>Hiasa, Yoichi</creatorcontrib><title>Association of abnormal glucose tolerance with liver‐related disease and cardiovascular diseases in patients with chronic hepatitis C</title><title>Hepatology research</title><addtitle>Hepatol Res</addtitle><description>Aim
Hepatitis C complicated by diabetes mellitus (DM) is considered a risk factor for the progression of fibrosis and development of hepatocellular carcinoma (HCC) and cardiovascular diseases. However, several studies may have lacked appropriate diagnosis of glucose intolerance. We aimed to examine the risk associated with abnormal glucose intolerance in the development of liver‐related diseases, including HCC and complications of liver cirrhosis, such as ascites, esophageal and gastric varices, and hepatic encephalopathy, and cardiovascular diseases in patients with hepatitis C accurately diagnosed with impaired glucose tolerance.
Methods
This longitudinal retrospective study included 365 patients with chronic hepatitis C admitted to Ehime University Hospital for anti‐hepatitis C therapy between September 1991 and January 2015. Patients were classified into normal glucose tolerance (NGT), prediabetes, and DM groups based on 75‐g oral glucose tolerance test results.
Results
Both univariate and multivariate (adjusted for potential confounders) analyses revealed a significantly higher risk of developing HCC and cardiovascular events in the DM group than in the NGT group. However, in multivariate analysis, liver‐related events, particularly liver cirrhosis complications, revealed no significant association. In addition, the prediabetes group had no significant risk of any outcome.
Conclusions
Patients with hepatitis C complicated by DM, compared with patients with hepatitis C with NGT or complicated with prediabetes, have a higher risk of HCC and cardiovascular disease events, but not liver‐related events, particularly in not developing liver cirrhosis complications. Therefore, appropriate follow‐up is required for patients with hepatitis C based on their glucose tolerance status.
For diabetes mellitus, neither normal glucose tolerance nor prediabetes, is a significant risk for hepatocellular carcinoma and cardiovascular events in patients with hepatitis C. However, diabetes mellitus is not a risk for developing complications of liver cirrhosis. Therefore, appropriate follow‐up based on glucose tolerance is required for patients with hepatitis C.</description><subject>Ascites</subject><subject>cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Chromium</subject><subject>chronic hepatitis C</subject><subject>Cirrhosis</subject><subject>Diabetes mellitus</subject><subject>Fibrosis</subject><subject>Glucose</subject><subject>glucose intolerance</subject><subject>Glucose tolerance</subject><subject>Hepatic encephalopathy</subject><subject>Hepatitis C</subject><subject>Hepatocellular carcinoma</subject><subject>Intolerance</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Multivariate analysis</subject><subject>prediabetes</subject><subject>Risk factors</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc9qFTEUh4MotlY3PoAE3BRh2vydySzLpVqhUCkK7oYzybnelNzkmsy0dOfOrc_ok5h2WhcuPJuE5OM7h_Mj5DVnR7zW8QZ3-YjLXugnZJ-bTjRMqq9P612atmmlavfIi1KuGOMdE-o52ZMdN7LvxT75eVJKsh4mnyJNawpjTHkLgX4Ls00F6ZQCZogW6Y2fNjT4a8y_f_zKGGBCR50vCBWD6KiF7Hy6hmLnAPnxq1Af6a42wDiVRWI3OUVvaR28vk--0NVL8mwNoeCrh_OAfHl_-nl11pxffPi4OjlvrDRcN2Zsle4ZqN4huLbDseUS9Wg0Z6NaGw6S9aiUg1Fbx6UVQks9cpS8E6bV8oAcLt5dTt9nLNOw9cViCBAxzWUQpi6tllAVffsPepXmHOt0ldJ93TNXbaXeLZTNqZSM62GX_Rby7cDZcBfPcBfPcB9Phd88KOdxi-4v-phHBfgC3PiAt_9RDWenny4X6R-Zp51w</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Konishi, Fumiaki</creator><creator>Miyake, Teruki</creator><creator>Watanabe, Takao</creator><creator>Tokumoto, Yoshio</creator><creator>Furukawa, Shinya</creator><creator>Matsuura, Bunzo</creator><creator>Yoshida, Osamu</creator><creator>Miyazaki, Masumi</creator><creator>Shiomi, Akihito</creator><creator>Kanzaki, Sayaka</creator><creator>Nakaguchi, Hironobu</creator><creator>Nakamura, Yoshiko</creator><creator>Imai, Yusuke</creator><creator>Koizumi, Mitsuhito</creator><creator>Yamamoto, Yasunori</creator><creator>Koizumi, Yohei</creator><creator>Hirooka, Masashi</creator><creator>Takeshita, Eiji</creator><creator>Kumagi, Teru</creator><creator>Ikeda, Yoshio</creator><creator>Abe, Masanori</creator><creator>Hiasa, Yoichi</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5634-5313</orcidid><orcidid>https://orcid.org/0000-0002-9905-5356</orcidid><orcidid>https://orcid.org/0000-0003-4117-339X</orcidid><orcidid>https://orcid.org/0000-0003-3008-691X</orcidid></search><sort><creationdate>202309</creationdate><title>Association of abnormal glucose tolerance with liver‐related disease and cardiovascular diseases in patients with chronic hepatitis C</title><author>Konishi, Fumiaki ; Miyake, Teruki ; Watanabe, Takao ; Tokumoto, Yoshio ; Furukawa, Shinya ; Matsuura, Bunzo ; Yoshida, Osamu ; Miyazaki, Masumi ; Shiomi, Akihito ; Kanzaki, Sayaka ; Nakaguchi, Hironobu ; Nakamura, Yoshiko ; Imai, Yusuke ; Koizumi, Mitsuhito ; Yamamoto, Yasunori ; Koizumi, Yohei ; Hirooka, Masashi ; Takeshita, Eiji ; Kumagi, Teru ; Ikeda, Yoshio ; Abe, Masanori ; Hiasa, Yoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3815-8b64590a49dead67eb613e5b8510b4f81a309e44dab5cd13c22535b1e31728653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Ascites</topic><topic>cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Chromium</topic><topic>chronic hepatitis C</topic><topic>Cirrhosis</topic><topic>Diabetes mellitus</topic><topic>Fibrosis</topic><topic>Glucose</topic><topic>glucose intolerance</topic><topic>Glucose tolerance</topic><topic>Hepatic encephalopathy</topic><topic>Hepatitis C</topic><topic>Hepatocellular carcinoma</topic><topic>Intolerance</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Multivariate analysis</topic><topic>prediabetes</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Konishi, Fumiaki</creatorcontrib><creatorcontrib>Miyake, Teruki</creatorcontrib><creatorcontrib>Watanabe, Takao</creatorcontrib><creatorcontrib>Tokumoto, Yoshio</creatorcontrib><creatorcontrib>Furukawa, Shinya</creatorcontrib><creatorcontrib>Matsuura, Bunzo</creatorcontrib><creatorcontrib>Yoshida, Osamu</creatorcontrib><creatorcontrib>Miyazaki, Masumi</creatorcontrib><creatorcontrib>Shiomi, Akihito</creatorcontrib><creatorcontrib>Kanzaki, Sayaka</creatorcontrib><creatorcontrib>Nakaguchi, Hironobu</creatorcontrib><creatorcontrib>Nakamura, Yoshiko</creatorcontrib><creatorcontrib>Imai, Yusuke</creatorcontrib><creatorcontrib>Koizumi, Mitsuhito</creatorcontrib><creatorcontrib>Yamamoto, Yasunori</creatorcontrib><creatorcontrib>Koizumi, Yohei</creatorcontrib><creatorcontrib>Hirooka, Masashi</creatorcontrib><creatorcontrib>Takeshita, Eiji</creatorcontrib><creatorcontrib>Kumagi, Teru</creatorcontrib><creatorcontrib>Ikeda, Yoshio</creatorcontrib><creatorcontrib>Abe, Masanori</creatorcontrib><creatorcontrib>Hiasa, Yoichi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Konishi, Fumiaki</au><au>Miyake, Teruki</au><au>Watanabe, Takao</au><au>Tokumoto, Yoshio</au><au>Furukawa, Shinya</au><au>Matsuura, Bunzo</au><au>Yoshida, Osamu</au><au>Miyazaki, Masumi</au><au>Shiomi, Akihito</au><au>Kanzaki, Sayaka</au><au>Nakaguchi, Hironobu</au><au>Nakamura, Yoshiko</au><au>Imai, Yusuke</au><au>Koizumi, Mitsuhito</au><au>Yamamoto, Yasunori</au><au>Koizumi, Yohei</au><au>Hirooka, Masashi</au><au>Takeshita, Eiji</au><au>Kumagi, Teru</au><au>Ikeda, Yoshio</au><au>Abe, Masanori</au><au>Hiasa, Yoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of abnormal glucose tolerance with liver‐related disease and cardiovascular diseases in patients with chronic hepatitis C</atitle><jtitle>Hepatology research</jtitle><addtitle>Hepatol Res</addtitle><date>2023-09</date><risdate>2023</risdate><volume>53</volume><issue>9</issue><spage>806</spage><epage>814</epage><pages>806-814</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>Aim
Hepatitis C complicated by diabetes mellitus (DM) is considered a risk factor for the progression of fibrosis and development of hepatocellular carcinoma (HCC) and cardiovascular diseases. However, several studies may have lacked appropriate diagnosis of glucose intolerance. We aimed to examine the risk associated with abnormal glucose intolerance in the development of liver‐related diseases, including HCC and complications of liver cirrhosis, such as ascites, esophageal and gastric varices, and hepatic encephalopathy, and cardiovascular diseases in patients with hepatitis C accurately diagnosed with impaired glucose tolerance.
Methods
This longitudinal retrospective study included 365 patients with chronic hepatitis C admitted to Ehime University Hospital for anti‐hepatitis C therapy between September 1991 and January 2015. Patients were classified into normal glucose tolerance (NGT), prediabetes, and DM groups based on 75‐g oral glucose tolerance test results.
Results
Both univariate and multivariate (adjusted for potential confounders) analyses revealed a significantly higher risk of developing HCC and cardiovascular events in the DM group than in the NGT group. However, in multivariate analysis, liver‐related events, particularly liver cirrhosis complications, revealed no significant association. In addition, the prediabetes group had no significant risk of any outcome.
Conclusions
Patients with hepatitis C complicated by DM, compared with patients with hepatitis C with NGT or complicated with prediabetes, have a higher risk of HCC and cardiovascular disease events, but not liver‐related events, particularly in not developing liver cirrhosis complications. Therefore, appropriate follow‐up is required for patients with hepatitis C based on their glucose tolerance status.
For diabetes mellitus, neither normal glucose tolerance nor prediabetes, is a significant risk for hepatocellular carcinoma and cardiovascular events in patients with hepatitis C. However, diabetes mellitus is not a risk for developing complications of liver cirrhosis. Therefore, appropriate follow‐up based on glucose tolerance is required for patients with hepatitis C.</abstract><cop>Netherlands</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37183992</pmid><doi>10.1111/hepr.13925</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5634-5313</orcidid><orcidid>https://orcid.org/0000-0002-9905-5356</orcidid><orcidid>https://orcid.org/0000-0003-4117-339X</orcidid><orcidid>https://orcid.org/0000-0003-3008-691X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1386-6346 |
| ispartof | Hepatology research, 2023-09, Vol.53 (9), p.806-814 |
| issn | 1386-6346 1872-034X |
| language | eng |
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| source | Wiley Online Library Journals |
| subjects | Ascites cardiovascular disease Cardiovascular diseases Chromium chronic hepatitis C Cirrhosis Diabetes mellitus Fibrosis Glucose glucose intolerance Glucose tolerance Hepatic encephalopathy Hepatitis C Hepatocellular carcinoma Intolerance Liver cancer Liver cirrhosis Liver diseases Multivariate analysis prediabetes Risk factors |
| title | Association of abnormal glucose tolerance with liver‐related disease and cardiovascular diseases in patients with chronic hepatitis C |
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