Downregulation of intestinal multidrug resistance transporter 1 in obese mice: Effect on its barrier function and role of TNF-α receptor 1 signaling

•A high-fat diet induced downregulation of intestinal multidrug resistance transporter 1 (Mdr-1).•High-fat diet–induced Mdr-1downregulation had negative outcomes for its barrier function.•Tumor necrosis factor α signaling played a role in Mdr-1 downregulation induced by a high-fat diet.•Impairment o...

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Veröffentlicht in:	Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2023-07, Vol.111, p.112050-112050, Article 112050
Hauptverfasser:	Barranco, María Manuela, Perdomo, Virginia Gabriela, Zecchinati, Felipe, Manarin, Romina, Massuh, Greta, Sigal, Nicolás, Vignaduzzo, Silvana, Mottino, Aldo Domingo, Villanueva, Silvina Stella Maris, García, Fabiana
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption analysis of variance Animals Bioavailability Cytokines Diet Diet, High-Fat Down-Regulation Drug resistance Drug Resistance, Multiple Enzyme-linked immunosorbent assay Enzymes Gene expression genes Glucose High fat diet Immunohistochemistry Inflammation Inflammatory response Insulin resistance Intestine intestines Laboratory animals Male males Mdr-1 Metabolic disorders Metabolic syndrome Mice Mice, Inbred C57BL Mice, Obese Multidrug resistance Multidrug resistant organisms multiple drug resistance Obesity Oral administration P-Glycoprotein Polymerase chain reaction protein synthesis Proteins quantitative polymerase chain reaction Receptors Rhodamine Rhodamine 123 rhodamines RNA, Messenger Signal transduction Signaling Small intestine Substrates t-test TNFR1 Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α tumor necrosis factors Variance analysis Western blotting
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