Photoswitchable Inhibitors to Optically Control Specific Kinase Activity

Potent and selective small-molecule inhibitors are valuable tools to elucidate the functions of protein kinases within complex signaling networks. Incorporation of a photoswitchable moiety into the inhibitor scaffold offers the opportunity to steer inhibitor potency with temporal precision, while th...

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Veröffentlicht in:	ACS chemical biology 2023-06, Vol.18 (6), p.1378-1387
Hauptverfasser:	Aguirre, Tim, Teichmann, Ellen, Römpp, Florian Q., Vivier, Ruthey, Bryant, Cole, Hulverson, Matthew A., Van Voorhis, Wesley C., Ojo, Kayode K., Doggett, J. Stone, Fiedler, Dorothea, Hecht, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Cryptosporidiosis Cryptosporidium - metabolism Humans Phosphorylation Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein Kinases - metabolism Toxoplasma
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