Drug-free and non-crosslinked chitosan/hyaluronic acid hybrid hydrogel for synergistic healing of infected diabetic wounds
The management of infected diabetic wounds remains a major challenge in clinical practice. Recently, multifunctional hydrogels have attracted much attention in the area of wound healing. Herein, we developed the drug-free and non-crosslinked chitosan (CS)/hyaluronic acid (HA) hybrid hydrogel, so as...
Gespeichert in:
| Veröffentlicht in: | Carbohydrate polymers 2023-08, Vol.314, p.120962-120962, Article 120962 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 120962 |
|---|---|
| container_issue | |
| container_start_page | 120962 |
| container_title | Carbohydrate polymers |
| container_volume | 314 |
| creator | Lin, Yao Xu, Jingchen Dong, Yuanhao Wang, Yue Yu, Chenhao Li, Yuanhong Zhang, Chaoliang Chen, Qianming Chen, Song Peng, Qiang |
| description | The management of infected diabetic wounds remains a major challenge in clinical practice. Recently, multifunctional hydrogels have attracted much attention in the area of wound healing. Herein, we developed the drug-free and non-crosslinked chitosan (CS)/hyaluronic acid (HA) hybrid hydrogel, so as to combine the multiple functions of CS and HA for synergistic healing of the methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic wound. As a result, CS/HA hydrogel showed the broad-spectrum antibacterial activity, the great capacity for promoting fibroblasts proliferation and migration, the excellent reactive oxygen species (ROS) scavenging ability, and the great cell-protection effects under oxidative stress. In the MRSA-infected diabetic mouse wounds, CS/HA hydrogel significantly promoted the wound healing via eliminating MRSA infection and enhancing epidermal regeneration, collagen deposition and angiogenesis. Considering the drug-free feature, the ready availability, the great biocompatibility and the excellent wound healing efficacy, CS/HA hydrogel may have great potentials in clinical use for the management of chronic diabetic wounds.
[Display omitted] |
| doi_str_mv | 10.1016/j.carbpol.2023.120962 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2813562213</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0144861723004277</els_id><sourcerecordid>2813562213</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-63341d25cabe54418bd7c2d0fc2d6e595fc237c4ff6dee883712d51d7eb49b5a3</originalsourceid><addsrcrecordid>eNqFkEtPGzEUha2qCMLjJ7TyspsJfs9kVVX0hYTEBtaWx75OnE7sYM8Upb8eh4RuuYt7Lfmcc3U_hD5RMqeEquv13Jrcb9MwZ4TxOWVkodgHNKNdu2goF-IjmhEqRNMp2p6h81LWpJai5BSd8Za2vKbM0L_veVo2PgNgEx2OKTY2p1KGEP-Aw3YVxlRMvF7tzDDlFIPFxgaHV7s-vw6X0xIG7FPGZRchL0MZq2gFpkYscfI4RA92rGEumB72n89piq5cohNvhgJXx3mBHn_-eLj53dzd_7q9-XbXWK7k2CjOBXVM2mqWQtCud61ljvjaFMiFrA_eWuG9cgBdV29jTlLXQi8WvTT8An055G5zepqgjHoTioVhMBHSVDTrKJeKMcqrVB6krwwyeL3NYWPyTlOi99j1Wh-x6z12fcBefZ-PK6Z-A-6_641zFXw9CKAe-jdA1sUGiBZcyBWOdim8s-IF3D-ZCg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2813562213</pqid></control><display><type>article</type><title>Drug-free and non-crosslinked chitosan/hyaluronic acid hybrid hydrogel for synergistic healing of infected diabetic wounds</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Lin, Yao ; Xu, Jingchen ; Dong, Yuanhao ; Wang, Yue ; Yu, Chenhao ; Li, Yuanhong ; Zhang, Chaoliang ; Chen, Qianming ; Chen, Song ; Peng, Qiang</creator><creatorcontrib>Lin, Yao ; Xu, Jingchen ; Dong, Yuanhao ; Wang, Yue ; Yu, Chenhao ; Li, Yuanhong ; Zhang, Chaoliang ; Chen, Qianming ; Chen, Song ; Peng, Qiang</creatorcontrib><description>The management of infected diabetic wounds remains a major challenge in clinical practice. Recently, multifunctional hydrogels have attracted much attention in the area of wound healing. Herein, we developed the drug-free and non-crosslinked chitosan (CS)/hyaluronic acid (HA) hybrid hydrogel, so as to combine the multiple functions of CS and HA for synergistic healing of the methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic wound. As a result, CS/HA hydrogel showed the broad-spectrum antibacterial activity, the great capacity for promoting fibroblasts proliferation and migration, the excellent reactive oxygen species (ROS) scavenging ability, and the great cell-protection effects under oxidative stress. In the MRSA-infected diabetic mouse wounds, CS/HA hydrogel significantly promoted the wound healing via eliminating MRSA infection and enhancing epidermal regeneration, collagen deposition and angiogenesis. Considering the drug-free feature, the ready availability, the great biocompatibility and the excellent wound healing efficacy, CS/HA hydrogel may have great potentials in clinical use for the management of chronic diabetic wounds.
[Display omitted]</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2023.120962</identifier><identifier>PMID: 37173016</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Biomaterials ; Chitosan - pharmacology ; Diabetes Mellitus ; Hyaluronic Acid - pharmacology ; Hydrogels ; Hydrogels - pharmacology ; Infection ; Methicillin-Resistant Staphylococcus aureus ; Mice ; Regeneration ; Tissue repair ; Wound dressing ; Wound Healing</subject><ispartof>Carbohydrate polymers, 2023-08, Vol.314, p.120962-120962, Article 120962</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-63341d25cabe54418bd7c2d0fc2d6e595fc237c4ff6dee883712d51d7eb49b5a3</citedby><cites>FETCH-LOGICAL-c365t-63341d25cabe54418bd7c2d0fc2d6e595fc237c4ff6dee883712d51d7eb49b5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2023.120962$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37173016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Yao</creatorcontrib><creatorcontrib>Xu, Jingchen</creatorcontrib><creatorcontrib>Dong, Yuanhao</creatorcontrib><creatorcontrib>Wang, Yue</creatorcontrib><creatorcontrib>Yu, Chenhao</creatorcontrib><creatorcontrib>Li, Yuanhong</creatorcontrib><creatorcontrib>Zhang, Chaoliang</creatorcontrib><creatorcontrib>Chen, Qianming</creatorcontrib><creatorcontrib>Chen, Song</creatorcontrib><creatorcontrib>Peng, Qiang</creatorcontrib><title>Drug-free and non-crosslinked chitosan/hyaluronic acid hybrid hydrogel for synergistic healing of infected diabetic wounds</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>The management of infected diabetic wounds remains a major challenge in clinical practice. Recently, multifunctional hydrogels have attracted much attention in the area of wound healing. Herein, we developed the drug-free and non-crosslinked chitosan (CS)/hyaluronic acid (HA) hybrid hydrogel, so as to combine the multiple functions of CS and HA for synergistic healing of the methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic wound. As a result, CS/HA hydrogel showed the broad-spectrum antibacterial activity, the great capacity for promoting fibroblasts proliferation and migration, the excellent reactive oxygen species (ROS) scavenging ability, and the great cell-protection effects under oxidative stress. In the MRSA-infected diabetic mouse wounds, CS/HA hydrogel significantly promoted the wound healing via eliminating MRSA infection and enhancing epidermal regeneration, collagen deposition and angiogenesis. Considering the drug-free feature, the ready availability, the great biocompatibility and the excellent wound healing efficacy, CS/HA hydrogel may have great potentials in clinical use for the management of chronic diabetic wounds.
[Display omitted]</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Biomaterials</subject><subject>Chitosan - pharmacology</subject><subject>Diabetes Mellitus</subject><subject>Hyaluronic Acid - pharmacology</subject><subject>Hydrogels</subject><subject>Hydrogels - pharmacology</subject><subject>Infection</subject><subject>Methicillin-Resistant Staphylococcus aureus</subject><subject>Mice</subject><subject>Regeneration</subject><subject>Tissue repair</subject><subject>Wound dressing</subject><subject>Wound Healing</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPGzEUha2qCMLjJ7TyspsJfs9kVVX0hYTEBtaWx75OnE7sYM8Upb8eh4RuuYt7Lfmcc3U_hD5RMqeEquv13Jrcb9MwZ4TxOWVkodgHNKNdu2goF-IjmhEqRNMp2p6h81LWpJai5BSd8Za2vKbM0L_veVo2PgNgEx2OKTY2p1KGEP-Aw3YVxlRMvF7tzDDlFIPFxgaHV7s-vw6X0xIG7FPGZRchL0MZq2gFpkYscfI4RA92rGEumB72n89piq5cohNvhgJXx3mBHn_-eLj53dzd_7q9-XbXWK7k2CjOBXVM2mqWQtCud61ljvjaFMiFrA_eWuG9cgBdV29jTlLXQi8WvTT8An055G5zepqgjHoTioVhMBHSVDTrKJeKMcqrVB6krwwyeL3NYWPyTlOi99j1Wh-x6z12fcBefZ-PK6Z-A-6_641zFXw9CKAe-jdA1sUGiBZcyBWOdim8s-IF3D-ZCg</recordid><startdate>20230815</startdate><enddate>20230815</enddate><creator>Lin, Yao</creator><creator>Xu, Jingchen</creator><creator>Dong, Yuanhao</creator><creator>Wang, Yue</creator><creator>Yu, Chenhao</creator><creator>Li, Yuanhong</creator><creator>Zhang, Chaoliang</creator><creator>Chen, Qianming</creator><creator>Chen, Song</creator><creator>Peng, Qiang</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230815</creationdate><title>Drug-free and non-crosslinked chitosan/hyaluronic acid hybrid hydrogel for synergistic healing of infected diabetic wounds</title><author>Lin, Yao ; Xu, Jingchen ; Dong, Yuanhao ; Wang, Yue ; Yu, Chenhao ; Li, Yuanhong ; Zhang, Chaoliang ; Chen, Qianming ; Chen, Song ; Peng, Qiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-63341d25cabe54418bd7c2d0fc2d6e595fc237c4ff6dee883712d51d7eb49b5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Biomaterials</topic><topic>Chitosan - pharmacology</topic><topic>Diabetes Mellitus</topic><topic>Hyaluronic Acid - pharmacology</topic><topic>Hydrogels</topic><topic>Hydrogels - pharmacology</topic><topic>Infection</topic><topic>Methicillin-Resistant Staphylococcus aureus</topic><topic>Mice</topic><topic>Regeneration</topic><topic>Tissue repair</topic><topic>Wound dressing</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Yao</creatorcontrib><creatorcontrib>Xu, Jingchen</creatorcontrib><creatorcontrib>Dong, Yuanhao</creatorcontrib><creatorcontrib>Wang, Yue</creatorcontrib><creatorcontrib>Yu, Chenhao</creatorcontrib><creatorcontrib>Li, Yuanhong</creatorcontrib><creatorcontrib>Zhang, Chaoliang</creatorcontrib><creatorcontrib>Chen, Qianming</creatorcontrib><creatorcontrib>Chen, Song</creatorcontrib><creatorcontrib>Peng, Qiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Yao</au><au>Xu, Jingchen</au><au>Dong, Yuanhao</au><au>Wang, Yue</au><au>Yu, Chenhao</au><au>Li, Yuanhong</au><au>Zhang, Chaoliang</au><au>Chen, Qianming</au><au>Chen, Song</au><au>Peng, Qiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug-free and non-crosslinked chitosan/hyaluronic acid hybrid hydrogel for synergistic healing of infected diabetic wounds</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2023-08-15</date><risdate>2023</risdate><volume>314</volume><spage>120962</spage><epage>120962</epage><pages>120962-120962</pages><artnum>120962</artnum><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>The management of infected diabetic wounds remains a major challenge in clinical practice. Recently, multifunctional hydrogels have attracted much attention in the area of wound healing. Herein, we developed the drug-free and non-crosslinked chitosan (CS)/hyaluronic acid (HA) hybrid hydrogel, so as to combine the multiple functions of CS and HA for synergistic healing of the methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic wound. As a result, CS/HA hydrogel showed the broad-spectrum antibacterial activity, the great capacity for promoting fibroblasts proliferation and migration, the excellent reactive oxygen species (ROS) scavenging ability, and the great cell-protection effects under oxidative stress. In the MRSA-infected diabetic mouse wounds, CS/HA hydrogel significantly promoted the wound healing via eliminating MRSA infection and enhancing epidermal regeneration, collagen deposition and angiogenesis. Considering the drug-free feature, the ready availability, the great biocompatibility and the excellent wound healing efficacy, CS/HA hydrogel may have great potentials in clinical use for the management of chronic diabetic wounds.
[Display omitted]</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37173016</pmid><doi>10.1016/j.carbpol.2023.120962</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0144-8617 |
| ispartof | Carbohydrate polymers, 2023-08, Vol.314, p.120962-120962, Article 120962 |
| issn | 0144-8617 1879-1344 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2813562213 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Anti-Bacterial Agents - pharmacology Biomaterials Chitosan - pharmacology Diabetes Mellitus Hyaluronic Acid - pharmacology Hydrogels Hydrogels - pharmacology Infection Methicillin-Resistant Staphylococcus aureus Mice Regeneration Tissue repair Wound dressing Wound Healing |
| title | Drug-free and non-crosslinked chitosan/hyaluronic acid hybrid hydrogel for synergistic healing of infected diabetic wounds |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T00%3A56%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Drug-free%20and%20non-crosslinked%20chitosan/hyaluronic%20acid%20hybrid%20hydrogel%20for%20synergistic%20healing%20of%20infected%20diabetic%20wounds&rft.jtitle=Carbohydrate%20polymers&rft.au=Lin,%20Yao&rft.date=2023-08-15&rft.volume=314&rft.spage=120962&rft.epage=120962&rft.pages=120962-120962&rft.artnum=120962&rft.issn=0144-8617&rft.eissn=1879-1344&rft_id=info:doi/10.1016/j.carbpol.2023.120962&rft_dat=%3Cproquest_cross%3E2813562213%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2813562213&rft_id=info:pmid/37173016&rft_els_id=S0144861723004277&rfr_iscdi=true |