ARID1A mutations in lung cancer: biology, prognostic role, and therapeutic implications

AT-interacting domain-rich protein 1A (ARID1A) gene functions as a tumor suppressor gene and is mutated in about 5–10% of lung cancers, mainly as loss-of-function (LOF) alterations.ARID1A deletion is closely related to many clinical features of lung cancer and is an independent predictor of poor pro...

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Veröffentlicht in:	Trends in molecular medicine 2023-08, Vol.29 (8), p.646-658
Hauptverfasser:	Jin, Fukang, Yang, Zhiguang, Shao, Jingbo, Tao, Jianxin, Reißfelder, Christoph, Loges, Sonja, Zhu, Lei, Schölch, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	ARID1A cell cycle regulation epithelial–mesenchymal transition lung cancer metabolic reprogramming SWI/SNF complex
Online-Zugang:	Volltext
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