Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model

Major depressive disorder (MDD) is a debilitating psychiatric disorder which is common and endangers human physical and mental health. Studies have shown that hesperidin could improve the symptoms of depression with unclear mechanisms. In this study, hesperidin was administered to chronic unpredicta...

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Veröffentlicht in:	European journal of pharmacology 2023-08, Vol.952, p.175670-175670, Article 175670
Hauptverfasser:	Cao, Hui, Yang, Dong, Nie, Kechao, Lin, Ruoheng, Peng, Luqi, Zhou, Xuhui, Zhang, Mei, Zeng, Ying, Liu, Lini, Huang, Wei
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Sprache:	eng
Schlagworte:	Animals Caspase 1 Depression - drug therapy Depressive Disorder, Major Hesperidin Hesperidin - pharmacology Hesperidin - therapeutic use Humans Inflammasomes - metabolism Major depressive disorder Mice Molecular Docking Simulation NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Pyroptosis Rats
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container_title	European journal of pharmacology
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creator	Cao, Hui Yang, Dong Nie, Kechao Lin, Ruoheng Peng, Luqi Zhou, Xuhui Zhang, Mei Zeng, Ying Liu, Lini Huang, Wei
description	Major depressive disorder (MDD) is a debilitating psychiatric disorder which is common and endangers human physical and mental health. Studies have shown that hesperidin could improve the symptoms of depression with unclear mechanisms. In this study, hesperidin was administered to chronic unpredictable mild stress (CUMS) depressed mice before behavioral test, network pharmacology analysis, RNA expression microarray analysis, pathway validation and molecular docking experiments. we found that hesperidin intervention could significantly improve the depressive symptoms and downregulate the expression level of pyroptosis pathway including caspase 1 (Casp1), interleukin 18 (IL18), interleukin-1β (IL-1β) and NOD-like receptor thermal protein domain associated protein 3 (NLRP3). In addition, we found that hesperidin could possibly bind to NLRP3. Our study demonstrated that hesperidin had huge potential as anti-depressive neuroprotectant, and may play a role in treating MDD by regulating NLRP3-mediated pyroptosis.
doi_str_mv	10.1016/j.ejphar.2023.175670
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Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-622483a752df4491bbc05ad660b92183769d44f08c591eb9e31dfb6caf93ba153</citedby><cites>FETCH-LOGICAL-c362t-622483a752df4491bbc05ad660b92183769d44f08c591eb9e31dfb6caf93ba153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2023.175670$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37169143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Hui</creatorcontrib><creatorcontrib>Yang, Dong</creatorcontrib><creatorcontrib>Nie, Kechao</creatorcontrib><creatorcontrib>Lin, Ruoheng</creatorcontrib><creatorcontrib>Peng, Luqi</creatorcontrib><creatorcontrib>Zhou, Xuhui</creatorcontrib><creatorcontrib>Zhang, Mei</creatorcontrib><creatorcontrib>Zeng, Ying</creatorcontrib><creatorcontrib>Liu, Lini</creatorcontrib><creatorcontrib>Huang, Wei</creatorcontrib><title>Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Major depressive disorder (MDD) is a debilitating psychiatric disorder which is common and endangers human physical and mental health. 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Our study demonstrated that hesperidin had huge potential as anti-depressive neuroprotectant, and may play a role in treating MDD by regulating NLRP3-mediated pyroptosis.</description><subject>Animals</subject><subject>Caspase 1</subject><subject>Depression - drug therapy</subject><subject>Depressive Disorder, Major</subject><subject>Hesperidin</subject><subject>Hesperidin - pharmacology</subject><subject>Hesperidin - therapeutic use</subject><subject>Humans</subject><subject>Inflammasomes - metabolism</subject><subject>Major depressive disorder</subject><subject>Mice</subject><subject>Molecular Docking Simulation</subject><subject>NLR Family, Pyrin Domain-Containing 3 Protein - metabolism</subject><subject>NLRP3</subject><subject>Pyroptosis</subject><subject>Rats</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rFEEQhhuJmDX6D0LoYy6z9vdMXwIhRCMsKqLnpj9q3F7mK92zkfn39jJJjp6qKJ6q4n0QuqRkSwlVnw5bOEx7m7aMML6ltVQ1eYM2tKl1RWrKztCGECoqprU-R-9zPhBCpGbyHTrnNVWaCr5Bjw-QJ0gxxAH3dsGxn9L4BDjAlCDnWNq89NM89hm7Bbs4FPIP_rb7-YNjOwQch7Y7wuBP03kPeFrSWPAcM57svP97ujlgi5OdcT8G6D6gt63tMnx8rhfo9-f7X3cP1e77l693t7vKc8XmSjEmGm5ryUIrhKbOeSJtUIo4zWjDa6WDEC1pvNQUnAZOQ-uUt63mzlLJL9D1ercEejxCnk0fs4euswOMx2xYQ7mUumlEQcWK-jTmnKA1U4q9TYuhxJxkm4NZZZuTbLPKLmtXzx-OrofwuvRitwA3KwAl51OEZLKPxRWEmMDPJozx_x_-AWkqkzk</recordid><startdate>20230805</startdate><enddate>20230805</enddate><creator>Cao, Hui</creator><creator>Yang, Dong</creator><creator>Nie, Kechao</creator><creator>Lin, Ruoheng</creator><creator>Peng, Luqi</creator><creator>Zhou, Xuhui</creator><creator>Zhang, Mei</creator><creator>Zeng, Ying</creator><creator>Liu, Lini</creator><creator>Huang, Wei</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230805</creationdate><title>Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model</title><author>Cao, Hui ; Yang, Dong ; Nie, Kechao ; Lin, Ruoheng ; Peng, Luqi ; Zhou, Xuhui ; Zhang, Mei ; Zeng, Ying ; Liu, Lini ; Huang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-622483a752df4491bbc05ad660b92183769d44f08c591eb9e31dfb6caf93ba153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Caspase 1</topic><topic>Depression - drug therapy</topic><topic>Depressive Disorder, Major</topic><topic>Hesperidin</topic><topic>Hesperidin - pharmacology</topic><topic>Hesperidin - therapeutic use</topic><topic>Humans</topic><topic>Inflammasomes - metabolism</topic><topic>Major depressive disorder</topic><topic>Mice</topic><topic>Molecular Docking Simulation</topic><topic>NLR Family, Pyrin Domain-Containing 3 Protein - metabolism</topic><topic>NLRP3</topic><topic>Pyroptosis</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, Hui</creatorcontrib><creatorcontrib>Yang, Dong</creatorcontrib><creatorcontrib>Nie, Kechao</creatorcontrib><creatorcontrib>Lin, Ruoheng</creatorcontrib><creatorcontrib>Peng, Luqi</creatorcontrib><creatorcontrib>Zhou, Xuhui</creatorcontrib><creatorcontrib>Zhang, Mei</creatorcontrib><creatorcontrib>Zeng, Ying</creatorcontrib><creatorcontrib>Liu, Lini</creatorcontrib><creatorcontrib>Huang, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Hui</au><au>Yang, Dong</au><au>Nie, Kechao</au><au>Lin, Ruoheng</au><au>Peng, Luqi</au><au>Zhou, Xuhui</au><au>Zhang, Mei</au><au>Zeng, Ying</au><au>Liu, Lini</au><au>Huang, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2023-08-05</date><risdate>2023</risdate><volume>952</volume><spage>175670</spage><epage>175670</epage><pages>175670-175670</pages><artnum>175670</artnum><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Major depressive disorder (MDD) is a debilitating psychiatric disorder which is common and endangers human physical and mental health. Studies have shown that hesperidin could improve the symptoms of depression with unclear mechanisms. In this study, hesperidin was administered to chronic unpredictable mild stress (CUMS) depressed mice before behavioral test, network pharmacology analysis, RNA expression microarray analysis, pathway validation and molecular docking experiments. we found that hesperidin intervention could significantly improve the depressive symptoms and downregulate the expression level of pyroptosis pathway including caspase 1 (Casp1), interleukin 18 (IL18), interleukin-1β (IL-1β) and NOD-like receptor thermal protein domain associated protein 3 (NLRP3). In addition, we found that hesperidin could possibly bind to NLRP3. 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subjects	Animals Caspase 1 Depression - drug therapy Depressive Disorder, Major Hesperidin Hesperidin - pharmacology Hesperidin - therapeutic use Humans Inflammasomes - metabolism Major depressive disorder Mice Molecular Docking Simulation NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Pyroptosis Rats
title	Hesperidin may improve depressive symptoms by binding NLRP3 and influencing the pyroptosis pathway in a rat model
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