Natural Chlorogenic Acid Planted Nanohybrids with Steerable Hyperthermia for Osteosarcoma Suppression and Bone Regeneration
Surgical resection is the most common approach for the treatment of osteosarcoma. However, two major complications, including residual tumor cells and large bone defects, often arise from the surgical resection of osteosarcoma. Discovering new strategies for programmatically solving the two above-me...
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Veröffentlicht in: | Advanced healthcare materials 2023-09, Vol.12 (23), p.e2300325-e2300325 |
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creator | Yang, Yu-Ying Zheng, Yuan Liu, Jun-Jin Chang, Zhuang-Peng Wang, Yue-Hua Shao, Yun-Yun Hou, Rui-Gang Zhang, Xiao |
description | Surgical resection is the most common approach for the treatment of osteosarcoma. However, two major complications, including residual tumor cells and large bone defects, often arise from the surgical resection of osteosarcoma. Discovering new strategies for programmatically solving the two above-mentioned puzzles has become a worldwide challenge. Herein, a novel one-step strategy is reported for natural phenolic acid planted nanohybrids with desired physicochemical properties and steerable photothermal effects for efficacious osteosarcoma suppression and bone healing. Nanohybrids are prepared based on the self-assembly of chlorogenic acid and gold nanorods through robust Au-catechol interface actions, featuring precise nanostructures, great water solubility, good stability, and adjustable hyperthermia generating capacity. As expected, on the one hand, these integrated nanohybrids can severely trigger apoptosis and suppress tumor growth with strong hyperthermia. On the other hand, with controllable mild NIR irradiation, the nanohybrids promote the expression of heat shock proteins and induce prominent osteogenic differentiation. This work initiates a brand-new strategy for assisting osteosarcoma surgical excision to resolve the blockage of residual tumor cells elimination and bone regeneration. |
doi_str_mv | 10.1002/adhm.202300325 |
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However, two major complications, including residual tumor cells and large bone defects, often arise from the surgical resection of osteosarcoma. Discovering new strategies for programmatically solving the two above-mentioned puzzles has become a worldwide challenge. Herein, a novel one-step strategy is reported for natural phenolic acid planted nanohybrids with desired physicochemical properties and steerable photothermal effects for efficacious osteosarcoma suppression and bone healing. Nanohybrids are prepared based on the self-assembly of chlorogenic acid and gold nanorods through robust Au-catechol interface actions, featuring precise nanostructures, great water solubility, good stability, and adjustable hyperthermia generating capacity. As expected, on the one hand, these integrated nanohybrids can severely trigger apoptosis and suppress tumor growth with strong hyperthermia. On the other hand, with controllable mild NIR irradiation, the nanohybrids promote the expression of heat shock proteins and induce prominent osteogenic differentiation. This work initiates a brand-new strategy for assisting osteosarcoma surgical excision to resolve the blockage of residual tumor cells elimination and bone regeneration.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202300325</identifier><identifier>PMID: 37167574</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Apoptosis ; Bone cancer ; Bone growth ; Bone healing ; Catechol ; Chlorogenic acid ; Controllability ; Differentiation (biology) ; Fever ; Gold ; Heat shock proteins ; Hyperthermia ; Interface stability ; Nanorods ; Near infrared radiation ; Osteosarcoma ; Phenolic acids ; Physicochemical properties ; Regeneration ; Regeneration (physiology) ; Sarcoma ; Self-assembly ; Tumor cells ; Tumors</subject><ispartof>Advanced healthcare materials, 2023-09, Vol.12 (23), p.e2300325-e2300325</ispartof><rights>2023 Wiley-VCH GmbH.</rights><rights>2023 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-d8aab94204648352527330943f15fa0026eb9a4f8df8c664b6df314af6835af03</citedby><cites>FETCH-LOGICAL-c323t-d8aab94204648352527330943f15fa0026eb9a4f8df8c664b6df314af6835af03</cites><orcidid>0000-0002-0242-1939</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37167574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Yu-Ying</creatorcontrib><creatorcontrib>Zheng, Yuan</creatorcontrib><creatorcontrib>Liu, Jun-Jin</creatorcontrib><creatorcontrib>Chang, Zhuang-Peng</creatorcontrib><creatorcontrib>Wang, Yue-Hua</creatorcontrib><creatorcontrib>Shao, Yun-Yun</creatorcontrib><creatorcontrib>Hou, Rui-Gang</creatorcontrib><creatorcontrib>Zhang, Xiao</creatorcontrib><title>Natural Chlorogenic Acid Planted Nanohybrids with Steerable Hyperthermia for Osteosarcoma Suppression and Bone Regeneration</title><title>Advanced healthcare materials</title><addtitle>Adv Healthc Mater</addtitle><description>Surgical resection is the most common approach for the treatment of osteosarcoma. However, two major complications, including residual tumor cells and large bone defects, often arise from the surgical resection of osteosarcoma. Discovering new strategies for programmatically solving the two above-mentioned puzzles has become a worldwide challenge. Herein, a novel one-step strategy is reported for natural phenolic acid planted nanohybrids with desired physicochemical properties and steerable photothermal effects for efficacious osteosarcoma suppression and bone healing. Nanohybrids are prepared based on the self-assembly of chlorogenic acid and gold nanorods through robust Au-catechol interface actions, featuring precise nanostructures, great water solubility, good stability, and adjustable hyperthermia generating capacity. As expected, on the one hand, these integrated nanohybrids can severely trigger apoptosis and suppress tumor growth with strong hyperthermia. On the other hand, with controllable mild NIR irradiation, the nanohybrids promote the expression of heat shock proteins and induce prominent osteogenic differentiation. This work initiates a brand-new strategy for assisting osteosarcoma surgical excision to resolve the blockage of residual tumor cells elimination and bone regeneration.</description><subject>Apoptosis</subject><subject>Bone cancer</subject><subject>Bone growth</subject><subject>Bone healing</subject><subject>Catechol</subject><subject>Chlorogenic acid</subject><subject>Controllability</subject><subject>Differentiation (biology)</subject><subject>Fever</subject><subject>Gold</subject><subject>Heat shock proteins</subject><subject>Hyperthermia</subject><subject>Interface stability</subject><subject>Nanorods</subject><subject>Near infrared radiation</subject><subject>Osteosarcoma</subject><subject>Phenolic acids</subject><subject>Physicochemical properties</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Sarcoma</subject><subject>Self-assembly</subject><subject>Tumor cells</subject><subject>Tumors</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkU1P3DAQhi1EBYhy5Ygs9cJlt_5OcoRVKUgIqgLnaBKPm6AkDrajasWfrxGwh85lRqNnPl9CTjlbc8bEd7DduBZMSMak0HvkSPBKrITR1f4uVuyQnMT4zLIZzU3JD8ihLLgpdKGOyOsdpCXAQDfd4IP_g1Pf0ou2t_TXAFNCS-9g8t22Cb2N9G-fOvqQEAM0A9Lr7YwhdRjGHqjzgd7HhD5CaP0I9GGZ54Ax9n6iMFl66SekvzGPyOUpZ7-SLw6GiCcf_pg8Xf143Fyvbu9_3mwubletFDKtbAnQVEowZVQptdCikJJVSjquHeQ_GGwqUK60rmyNUY2xTnIFzmQaHJPH5Py97xz8y4Ix1WMfWxzygeiXWIuSS63Lqioz-u0_9NkvYcrbZSr_stBaV5lav1Nt8DEGdPUc-hHCtuasflOmflOm3imTC84-2i7NiHaHf-og_wHTSYoO</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Yang, Yu-Ying</creator><creator>Zheng, Yuan</creator><creator>Liu, Jun-Jin</creator><creator>Chang, Zhuang-Peng</creator><creator>Wang, Yue-Hua</creator><creator>Shao, Yun-Yun</creator><creator>Hou, Rui-Gang</creator><creator>Zhang, Xiao</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0242-1939</orcidid></search><sort><creationdate>20230901</creationdate><title>Natural Chlorogenic Acid Planted Nanohybrids with Steerable Hyperthermia for Osteosarcoma Suppression and Bone Regeneration</title><author>Yang, Yu-Ying ; 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However, two major complications, including residual tumor cells and large bone defects, often arise from the surgical resection of osteosarcoma. Discovering new strategies for programmatically solving the two above-mentioned puzzles has become a worldwide challenge. Herein, a novel one-step strategy is reported for natural phenolic acid planted nanohybrids with desired physicochemical properties and steerable photothermal effects for efficacious osteosarcoma suppression and bone healing. Nanohybrids are prepared based on the self-assembly of chlorogenic acid and gold nanorods through robust Au-catechol interface actions, featuring precise nanostructures, great water solubility, good stability, and adjustable hyperthermia generating capacity. As expected, on the one hand, these integrated nanohybrids can severely trigger apoptosis and suppress tumor growth with strong hyperthermia. 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subjects | Apoptosis Bone cancer Bone growth Bone healing Catechol Chlorogenic acid Controllability Differentiation (biology) Fever Gold Heat shock proteins Hyperthermia Interface stability Nanorods Near infrared radiation Osteosarcoma Phenolic acids Physicochemical properties Regeneration Regeneration (physiology) Sarcoma Self-assembly Tumor cells Tumors |
title | Natural Chlorogenic Acid Planted Nanohybrids with Steerable Hyperthermia for Osteosarcoma Suppression and Bone Regeneration |
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