Self-delivering mRNA inhibitors of MK2 improve outcomes after spinal cord injury

Functional recovery and tissue damage after spinal cord injury (SCI) are influenced by secondary damage mechanisms, including inflammation. The inflammatory response after SCI relies on a variety of cell types with both protective and cytotoxic functions. The macrophage derived MAPK-activated protei...

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Veröffentlicht in:	Journal of neuroimmunology 2023-06, Vol.379, p.578103-578103, Article 578103
Hauptverfasser:	Page, Justin J., Almanza, Jose Rosas, Xiong, Shuana, Aishwarya, Veenu, Kroner, Antje
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Inflammation Inflammation - metabolism Macrophages - metabolism Mice MK2 mRNA inhibitors Oligonucleotides, Antisense - metabolism Oligonucleotides, Antisense - pharmacology Oligonucleotides, Antisense - therapeutic use Recovery of Function - physiology RNA, Messenger Spinal Cord - metabolism Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Spinal cord injury
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