Atroposelective Sulfenylation of Biaryl Anilines Catalyzed by Chiral SPINOL-Derived Selenide
The atroposelective electrophilic sulfenylation of biaryl anilines has been realized for the first time. The reaction is enabled by a new chiral 6,6′-dianisole substituted SPINOL-derived selenide. A variety of axially chiral sulfur-containing biaryl aniline compounds were obtained in moderate to exc...
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| Veröffentlicht in: | Organic letters 2023-05, Vol.25 (19), p.3445-3450 |
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| container_title | Organic letters |
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| creator | Zhang, Xin-Yu Zhu, Deng Huo, Yu-Xuan Chen, Ling-Ling Chen, Zhi-Min |
| description | The atroposelective electrophilic sulfenylation of biaryl anilines has been realized for the first time. The reaction is enabled by a new chiral 6,6′-dianisole substituted SPINOL-derived selenide. A variety of axially chiral sulfur-containing biaryl aniline compounds were obtained in moderate to excellent yields with moderate to excellent enantioselectivities. The experimental results suggest that catalyst rigidity is important for the high atroposelectivity. |
| doi_str_mv | 10.1021/acs.orglett.3c01002 |
| format | Article |
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| source | ACS Publications |
| title | Atroposelective Sulfenylation of Biaryl Anilines Catalyzed by Chiral SPINOL-Derived Selenide |
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