CD4−/CD8− double-negative tumor-infiltrating lymphocytes expanded from solid tumor tissue suppress the proliferation of tumor cells in an MHC-independent way

Purpose Tumor-infiltrating lymphocytes (TILs) have shown remarkable clinical responses in some patients with advanced solid tumors. As a rare subset of TILs, CD4 − /CD8 − double-negative T cells (DNTs) were poorly known. This study aims to investigate the characteristics and function of CD3 + CD4 −...

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