TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria

PINK1 is activated by autophosphorylation and forms a high-molecular-weight complex, thereby initiating the selective removal of damaged mitochondria by autophagy. Other than translocase of the outer mitochondrial membrane complexes, members of PINK1-containing protein complexes remain obscure. By m...

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Veröffentlicht in:	Cell reports (Cambridge) 2023-05, Vol.42 (5), p.112454-112454, Article 112454
Hauptverfasser:	Akabane, Shiori, Watanabe, Kiyona, Kosako, Hidetaka, Yamashita, Shun-ichi, Nishino, Kohei, Kato, Masahiro, Sekine, Shiori, Kanki, Tomotake, Matsuda, Noriyuki, Endo, Toshiya, Oka, Toshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Carrier Proteins - metabolism Membrane Proteins - metabolism Mitochondria - metabolism Mitochondrial Membranes - metabolism mitochondrial quality control OMA1 PINK1 Protein Kinases - metabolism TIM23
Online-Zugang:	Volltext
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