Exosome-transmitted FOSL1 from cancer-associated fibroblasts drives colorectal cancer stemness and chemo-resistance through transcriptionally activating ITGB4

Cancer-associated fibroblasts (CAFs) have been proved to facilitate colorectal cancer (CRC) development, either with boosting chemo-resistance by communicating with CRC cells in the tumor microenvironment. However, the underlying molecular mechanisms remain largely unclear. Relative expressions of F...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular and cellular biochemistry 2024-03, Vol.479 (3), p.665-677
Hauptverfasser:	Lin, Shanshan, Zhu, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biochemistry Biomedical and Life Sciences Cancer Cancer Research Cancer-Associated Fibroblasts - metabolism Cardiology Cell culture Cell growth Cell Line, Tumor Cell Proliferation Cell self-renewal Cholecystokinin Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Communication Exosomes Exosomes - metabolism Fibroblasts Flow cytometry Gene regulation Humans Immunofluorescence Integrin beta4 - metabolism Life Sciences Medical Biochemistry Medical prognosis Molecular modelling Oxaliplatin Oxaliplatin - metabolism Prognosis Stroma Survival analysis Transcription Tumor Microenvironment
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!