Rigorous Characterization of Allosteric Modulation of the Human Metabotropic Glutamate Receptor 1 Reveals Probe- and Assay-Dependent Pharmacology

Allosteric modulation of metabotropic glutamate receptor subtype 1 (mGlu1) represents a viable therapeutic target for treating numerous central nervous system disorders. Although multiple chemically distinct mGlu1 positive (PAMs) and negative (NAMs) allosteric modulators have been identified, drug d...

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Veröffentlicht in:	Molecular pharmacology 2023-06, Vol.103 (6), p.325-338
Hauptverfasser:	Muraleetharan, Ashwin, Wang, Yuyang, Rowe, Matthew C., Gould, Ashleigh, Gregory, Karen J., Hellyer, Shane D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Glutamic Acid - metabolism Humans Ligands Quisqualic Acid Receptor, Metabotropic Glutamate 5 - metabolism
Online-Zugang:	Volltext
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